DRSC/TRiP Functional Genomics Resources

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Protein Alignment csw and PTPN22

DIOPT Version :10

Sequence 1:NP_477131.1 Gene:csw / 45278 FlyBaseID:FBgn0000382 Length:945 Species:Drosophila melanogaster
Sequence 2:NP_057051.4 Gene:PTPN22 / 26191 HGNCID:9652 Length:807 Species:Homo sapiens


Alignment Length:495 Identity:122/495 - (24%)
Similarity:181/495 - (36%) Gaps:184/495 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   317 ARVEQLVKGGFWEEFESLQQDSR-----DTFSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEH 376
            |:.:::.|..|..||..|::.|.     .|:......|.:|..||||::|||||::||: |.:..
Human    14 AQSKKITKEEFANEFLKLKRQSTKYKADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVE-LSLIT 77

  Fly   377 SVAGAEYINANYIRLPTDGDLYNMSSSSESLNSSVPSCPACTAAQTQRNCSNCQLQNKTCVQCAV 441
            |...:.|||||:|:                                                   
Human    78 SDEDSSYINANFIK--------------------------------------------------- 91

  Fly   442 KSAILPYSNCATCSRKSDSLSKHKRSESSASSSPSSGSGSGPGSSGTSGVSSVNGPGTPTNLTSG 506
                                                               .|.||         
Human    92 ---------------------------------------------------GVYGP--------- 96

  Fly   507 TAGCLVGLLKRHSNDSSGAVSISMAEREREREREMFKTYIATQGCLLTQQVNTVTDFWNMVWQEN 571
                                                |.||||||.|.|    |:.|||.|:|:.:
Human    97 ------------------------------------KAYIATQGPLST----TLLDFWRMIWEYS 121

  Fly   572 TRVIVMTTKEYERGKEKCARYWPDEGRSE-QFGHARIQCVSENSTSDYTLREFLVSWRDQPARRI 635
            ..:|||...|||.||:||.|||.:.|..: :||...:.|.:|...|||.:|...|.:..: .|.|
Human   122 VLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFNSE-TRTI 185

  Fly   636 FHYHFQVWPDHGVPADPGCVLNFLQDVNTRQSHLAQAGEKPGPICVHCSAGIGRTGTFIVIDMIL 700
            :.:|::.||||.||:....:|..:.||...|.      :...|||:|||||.||||....||...
Human   186 YQFHYKNWPDHDVPSSIDPILELIWDVRCYQE------DDSVPICIHCSAGCGRTGVICAIDYTW 244

  Fly   701 DQIVRNGLDTE-IDIQRTIQMVRSQRSGLVQTEAQYKFVYYAVQHYIQTLIARKRAEEQSLQVGR 764
             .::::|:..| ..:...|:.:|:||..||||:.||:.||.||                 |::.:
Human   245 -MLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAV-----------------LELFK 291

  Fly   765 EYTNIKYTGEIGNDSQRSPLPPAISSISLVPSKTPLTPTS 804
            ...::......|.:||.....|..:......|.:|..|.|
Human   292 RQMDVIRDKHSGTESQAKHCIPEKNHTLQADSYSPNLPKS 331

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cswNP_477131.1 SH2_C-SH2_SHP_like 211..307 CDD:198185
PTPc-N11_6 352..748 CDD:350392 104/397 (26%)
PTPN22NP_057051.4 PTPc-N22 57..290 CDD:350450 104/409 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 676..700
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 724..746
Blue background indicates that the domain is not in the aligned region.

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