Protein Alignment csw and ZK616.65

DIOPT Version :10

• Sequence 1: NP_477131.1
• Gene: csw / 45278
• FlyBaseID: FBgn0000382
• Length: 945
• Species: Drosophila melanogaster
• Sequence 2: NP_001293838.1
• Gene: ZK616.65 / 24105295
• WormBaseID: WBGene00235383
• Length: 543
• Species: Caenorhabditis elegans
• Alignment Length: 725
• Identity: 146/725 - (20%)
• Similarity: 239/725 - (32%)
• Gaps: 248/725 - (34%)

  Fly    45 NAYNNQRNFEYERAIQAHYGSKGRRSEERERSGKFKASKGRKAKVTPPTETPEAQEPACKNCMTH 109
            |.:|.:...|..:..:|..|||..:|               |.|.:|..:..|
 Worm     2 NMFNRKAKQEVTKKPEASNGSKNSKS---------------KTKFSPNQKRRE------------ 39

  Fly   110 DELAQIIKGVAKGADAQRNRDNRLQRRRRPLSAQPSAAASAS---TSTESLHRLTPSPQASYPAT 171
                      .|.:|:.....::..||.:|:.|.||:.:..|   ...:|:..:........|.:
 Worm    40 ----------VKKSDSDTESSHKNTRRGKPVPAPPSSNSKGSNDKNKRKSVQEVVKKVVNHIPFS 94

  Fly   172 PTSW-TATPPQFPAAFGGASCSNSTLSLLATMRVQLHGYTWFHGNLSGKEAEKLILERGKNGSFL 235
            |:.. |:|||.                              ..||  .|..:..::||.
 Worm    95 PSKQPTSTPPV------------------------------SEGN--RKRLQTKVVERS------ 121

  Fly   236 VRESQSKPGDFVLSVRTDDKVTHVMIRWQDKKYDVGGGESFGTLSELI--DHYKRNPMVETCGTV 298
             .:.:|:...||..:..:::          :........|....:|.:  .:.||:|...|
 Worm   122 -NQIESEMDSFVKKIEPNER----------RATQYNHSNSLSGSNEAVPPGNVKRSPQKAT---- 171

  Fly   299 VHLRQPFNATRITAAGINARVEQLVKGGFWEEFESLQQDSRDTFSRNEGYKQENRLKNRYRNILP 363
                .|...|| :..|::...|.:        :....:.|.|              |.:.....|
 Worm   172 ----HPIRTTR-SLIGLDGETEAV--------YSKTSKTSPD--------------KGKVTADSP 209

  Fly   364 YDHTRVKLLDVEH-------SVAGAEYINANYIRLPTDGDLYNMSSSSESLN------SSVPSCP 415
            ......|.|:...       |:|..|.....|.:|..|   :.|||...:|:      |::|..|
 Worm   210 RSRRTSKSLEENSSEANDSISLADDEETREAYRKLFKD---FAMSSQKMTLDDFKQEFSNLPGDP 271

  Fly   416 ---ACTAAQTQRNCSNCQLQNKTCVQCA-VKSAILPYSNCATCSRKSDSLSKHKRSESSASSSPS 476
               .|||.....|....:..|..|:..: |:..::|..|
 Worm   272 PSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKN-------------------------- 310

  Fly   477 SGSGSGPGSSGTSGVSSVNGPGTPTNLTSGTAGCLVGLLKRHSNDSSGAVSISMAEREREREREM 541
                    |:.....:.:..|                .|||
 Worm   311 --------STDYIHANYIRSP----------------FLKR------------------------ 327

  Fly   542 FKTYIATQGCLLTQQVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGR-SEQFGHA 605
              .||.|||    .:..|..|||.|:|||||..|||..:..|..:||||.|:|.... ..||...
 Worm   328 --GYILTQG----PKKETRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRNAHCCLQFDKM 386

  Fly   606 RIQCVSENSTSDYTLREFLVSWR-----DQPARRIFHYHFQVWPDHGVPADPGCVLNFLQDVNTR 665
            .:      |..|.|:.:.||:.|     :...|.|.|:.::.|||..||.....:|..|:.:..|
 Worm   387 SV------SYEDSTVNKSLVTTRLNLSYEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRAR 445

  Fly   666 QSHLAQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLDTEIDIQRTIQMVR-SQRSGLV 729
            .:          |..:|||||:||:||.:.:::.|..|  :...|..||::.:..:| :.|:..|
 Worm   446 ST----------PPVIHCSAGVGRSGTLMAVEIALQSI--HSHFTLPDIKQIVSHLRVTGRAASV 498

  Fly   730 QTEAQYKFVY 739
            ||..||..::
 Worm   499 QTLQQYMLIW 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
csw	NP_477131.1	SH2_C-SH2_SHP_like	211..307	CDD:198185	15/97 (15%)
		PTPc-N11_6	352..748	CDD:350392	97/412 (24%)
ZK616.65	NP_001293838.1	PTZ00108	<9..236	CDD:240271	53/343 (15%)
		PTPc	260..513	CDD:214550	83/347 (24%)