Protein Alignment csw and Ptprt

DIOPT Version :10

• Sequence 1: NP_477131.1
• Gene: csw / 45278
• FlyBaseID: FBgn0000382
• Length: 945
• Species: Drosophila melanogaster
• Sequence 2: XP_017172075.1
• Gene: Ptprt / 19281
• MGIID: 1321152
• Length: 1487
• Species: Mus musculus
• Alignment Length: 859
• Identity: 206/859 - (23%)
• Similarity: 292/859 - (33%)
• Gaps: 336/859 - (39%)

  Fly   139 PLSA--------QPSAAASASTSTESLHRLTPSPQAS---YPATPTSWTATPPQFPAAFGGASCS 192
            |||.        |..:.|:..|....:...|.:|..|   .|.||.....|         |||..
Mouse   698 PLSPLKSYSIYFQALSKANGETKINCVRLATKAPMGSAQVTPGTPLCLLTT---------GASTQ 753

  Fly   193 NST----------------------------LSLLATMRVQLHGYTWFHGNLSGKEAEKLILERG 229
            ||.                            |.::.|::.:.:.|::.: .||.:   ||..::.
Mouse   754 NSNTVEPEKQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRRRNAYSYSY-YLSQR---KLAKKQK 814

  Fly   230 KNGSFLVRE-----SQSKPGDFVLSVRTDDKVTHVMIRWQDKKYDVGG--GESFGTLSELIDHYK 287
            :..|...||     |..||...:.:.|.|:       .:.....||.|  ..|.|.||:.....:
Mouse   815 ETQSGAQREMGPVASTDKPTAKLGTNRNDE-------GFSSSSQDVNGFTDGSRGELSQPTLTIQ 872

  Fly   288 RNPMVETCGTV--VHLRQPFNATRITAAGINARVEQLVKG---GFWEEFESLQQDSRDTFSRNEG 347
            .:| ..||..|  .:.|..|... |..|.:...:.|:.:|   ||.||:|:|.:.  .|.|.:..
Mouse   873 THP-YRTCDPVEMSYPRDQFQPA-IRVADLLQHITQMKRGQGYGFKEEYEALPEG--QTASWDTA 933

  Fly   348 YKQENRLKNRYRNILPYDHTRVKLLDVE---HSVAGAEYINANYIRLPTDGDLYNMSSSSESLNS 409
            .:.|||.||||.||:.|||:||:||.::   ||    :|||||||    ||
Mouse   934 KEDENRNKNRYGNIISYDHSRVRLLVLDGDPHS----DYINANYI----DG-------------- 976

  Fly   410 SVPSCPACTAAQTQRNCSNCQLQNKTCVQCAVKSAILPYSNCATCSRKSDSLSKHKRSESSASSS 474
                                                                 .|:
Mouse   977 -----------------------------------------------------YHR--------- 979

  Fly   475 PSSGSGSGPGSSGTSGVSSVNGPGTPTNLTSGTAGCLVGLLKRHSNDSSGAVSISMAERERERER 539
                                                     .||
Mouse   980 -----------------------------------------PRH--------------------- 982

  Fly   540 EMFKTYIATQGCLLTQQVNTVTDFWNMVWQENTRVIVMTTKEYERGKE----------------- 587
                 ||||||    ....||.|||.|:||||:..|||.|...|.|:.
Mouse   983 -----YIATQG----PMQETVKDFWRMIWQENSASIVMVTNLVEVGRHPAEHTVGTATLGRAASP 1038

  Fly   588 ---KCARYWPDEGRSEQFGHARIQCVSENSTSDYTLREFLVSWRD-QPARRIFHYHFQVWPDHGV 648
               ||.|||||:  :|.:|..::..:.....::|.:|.|.|..:. ...|.:..:||..||||||
Mouse  1039 GMVKCVRYWPDD--TEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGV 1101

  Fly   649 PADPGCVLNFLQDVNTRQSHLAQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLDTEID 713
            |.....:|.|::.|.....      .:.|||.||||||.||||.||.||.:||.....|:   :|
Mouse  1102 PCYATGLLGFVRQVKFLNP------PEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGV---VD 1157

  Fly   714 IQRTIQMVRSQRSGLVQTEAQYKFVYYAVQHYIQTLIARKRA----EEQSLQVGREYTNIKYTGE 774
            |...::.:|:||..|||||.||.||:.|:   ::..:....|    |.:||     |.||.....
Mouse  1158 IFNCVRELRAQRVNLVQTEEQYVFVHDAI---LEACLCGNTAIPVCEFRSL-----YYNISRLDP 1214

  Fly   775 IGNDSQRSPLPPAISSISLVPSKTP-LTPTSADLGTGMGLSMGVGMGVGNKHASKQQPPLPVVNC 838
            ..|.||   :.....::::|   || :.|...          .:|:...|...::....||:..|
Mouse  1215 QTNSSQ---IKDEFQTLNIV---TPRVRPEDC----------SIGLLPRNHDKNRSMDVLPLDRC 1263

  Fly   839 NNNNNGIGNSGCSNGGGSSTTSSSNGSSNGNINALLGGIGLGLGGNMRKSNFYSDSLKQQQQREE 903
                             .....|.:|.|:..|||.|                 .||.||
Mouse  1264 -----------------LPFLISVDGESSNYINAAL-----------------MDSHKQ------ 1288

  Fly   904 QAPAGAGKMQQPAP 917
              ||.....|.|.|
Mouse  1289 --PAAFVVTQHPLP 1300

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
csw	NP_477131.1	SH2_C-SH2_SHP_like	211..307	CDD:198185	25/104 (24%)
		PTPc-N11_6	352..748	CDD:350392	112/419 (27%)
Ptprt	XP_017172075.1	MAM	36..193	CDD:214533
		Ig	200..285	CDD:472250
		fn3	298..364	CDD:394996
		FN3	394..484	CDD:238020
		fn3	506..581	CDD:394996
		R-PTPc-T-1	936..1192	CDD:350478	113/424 (27%)
		R-PTPc-T-2	1277..1482	CDD:350482	13/49 (27%)