Protein Alignment csw and Ptpn4

DIOPT Version :10

• Sequence 1: NP_477131.1
• Gene: csw / 45278
• FlyBaseID: FBgn0000382
• Length: 945
• Species: Drosophila melanogaster
• Sequence 2: NP_064317.2
• Gene: Ptpn4 / 19258
• MGIID: 1099792
• Length: 926
• Species: Mus musculus
• Alignment Length: 823
• Identity: 177/823 - (21%)
• Similarity: 261/823 - (31%)
• Gaps: 361/823 - (43%)

  Fly    50 QRNFEYERAIQAHY---GSK----GRRSEERERSGKFKASKGRKAKVTPPTETPEAQEPACKNCM 107
            |:||      .|||   |||    ||...:..:.||.||:|.|....:|       .:|..:..|
Mouse   317 QKNF------FAHYFTLGSKFRYCGRTEVQSVQYGKEKANKDRVFARSP-------SKPLARKLM 368

  Fly   108 THDELAQIIKGVAKGADAQRN--RDNRLQRRRRPLSAQPSAAASASTS-TESLHRLTP------- 162
            ..:.::             ||  .|:||:.:..|..:.|......::| |:...|:.|
Mouse   369 DWEVVS-------------RNSLSDDRLETQSLPSRSPPGTPNHRNSSFTQEATRVRPSSVGHLV 420

  Fly   163 -------------------SPQA------SYPATPTSWTATPPQFPA------AFGGASCSNSTL 196
                               |.||      |.|:..|.....||..|.      ::.....|||..
Mouse   421 DHVVHMSPSEDFVSQRSPSSTQANSIVLESSPSQETPEDGQPPALPPKQSKKNSWNQIHFSNSQQ 485

  Fly   197 SL-----------------------------LATMRVQLHGYTWFHGNLSG-------------- 218
            .|                             |..|:...:|...|  |:.|
Mouse   486 DLVTHTNESFDVPSSPEKSTPNGGIPHDNLVLIKMKPDENGRFGF--NVKGGYDQKMPVIVSRVA 548

  Fly   219 ------------KEAEKLILERGKNGS---------FLVRESQSKPGDFVLSVRTD---DKVTHV 259
                        .|.::::|..|::.:         |:....:...|:.||.||.:   |.|...
Mouse   549 PGTPADLCVPRLNEGDQVVLINGRDIAEHTHDQVVLFIKASCEKHSGELVLLVRPNAVYDVVEEK 613

  Fly   260 MIRWQDKKYDVGGGESFGTLSELI--------DHYKRNPMVETCGTVVHLRQPFNATRITAAGIN 316
            :....|.:|          :.|..        ||..|..|::.
Mouse   614 LESEPDFQY----------IPEKAPLDSVHQDDHSLRESMIQL---------------------- 646

  Fly   317 ARVEQLVKGGFWEEFESLQQDSRDTFSRNEGYKQ------ENRLKNRYRNILPYDHTRVKLLDVE 375
              .|.|:.|....:|:.|       :.:..|...      :|..|||||:|.|||.|||.|...|
Mouse   647 --AEGLITGTVLAQFDQL-------YRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVLLKGNE 702

  Fly   376 HSVAGAEYINANYIRLPTDGDLYNMSSSSESLNSSVPSCPACTAAQTQRNCSNCQLQNKTCVQCA 440
                  :|||||||                  |..:||
Mouse   703 ------DYINANYI------------------NMEIPS--------------------------- 716

  Fly   441 VKSAILPYSNCATCSRKSDSLSKHKRSESSASSSPSSGSGSGPGSSGTSGVSSVNGPGTPTNLTS 505
                                                               ||:
Mouse   717 ---------------------------------------------------SSI----------- 719

  Fly   506 GTAGCLVGLLKRHSNDSSGAVSISMAEREREREREMFKTYIATQGCLLTQQVNTVTDFWNMVWQE 570
                                                ...|||.||.|    .:|..|||.|.|::
Mouse   720 ------------------------------------INQYIACQGPL----PHTCKDFWQMTWEQ 744

  Fly   571 NTRVIVMTTKEYERGKEKCARYWPDEGRSEQFGHARIQCVSENSTSDYTLREF-LVSWRDQPARR 634
            .:.::||.|.:.|||:.||.:|||:...|..:|..::.|.||.....|..|:. |.:.....:|:
Mouse   745 GSSMVVMLTTQVERGRVKCHQYWPEPSESSSYGCYQVTCHSEEGNPAYIFRKMTLFNQEKNESRQ 809

  Fly   635 IFHYHFQVWPDHGVPADPGCVLNFLQDVNTRQSHLAQAGEKPGPICVHCSAGIGRTGTFIVIDMI 699
            :....:..|||||||.|....|:|:..|..:     :|| |..||.|||||||||||..|.::..
Mouse   810 LTQIQYTAWPDHGVPDDSSDFLDFVCHVRDQ-----RAG-KEEPIIVHCSAGIGRTGVLITMETA 868

  Fly   700 LDQIVRNGLDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYAV 742
            :..|..|.....:||.||   :|.||:.::||.:||:||..|:
Mouse   869 MCLIECNQPVYPLDIVRT---MRDQRAMMIQTPSQYRFVCEAI 908

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
csw	NP_477131.1	SH2_C-SH2_SHP_like	211..307	CDD:198185	21/141 (15%)
		PTPc-N11_6	352..748	CDD:350392	103/392 (26%)
Ptpn4	NP_064317.2	B41	30..222	CDD:214604
		FERM_C_PTPN4_PTPN3_like	216..310	CDD:270010
		FA	324..365	CDD:462582	14/47 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	379..412		8/32 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	429..474		9/44 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	492..511		0/18 (0%)
		PDZ_PTPN3-4-like	513..602	CDD:467190	13/90 (14%)
		PTP_DSP_cys	641..914	CDD:475123	110/461 (24%)