DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment csw and Ptpn11

DIOPT Version :9

Sequence 1:	NP_477131.1	Gene:	csw / 45278	FlyBaseID:	FBgn0000382	Length:	945	Species:	Drosophila melanogaster
Sequence 2:	NP_035332.1	Gene:	Ptpn11 / 19247	MGIID:	99511	Length:	597	Species:	Mus musculus

Alignment Length:	718	Identity:	288/718 - (40%)
Similarity:	370/718 - (51%)	Gaps:	232/718 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 LTPSPQASYPATPTSWTATPPQFPAA---------------------FGGASCSNSTLSLLATMR 203
            ||.....|:.|.|:.  :.|..|..:                     :||...  :||:.|....
Mouse    21 LTRGVDGSFLARPSK--SNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKF--ATLAELVQYY 81

  Fly   204 VQLHGY-----------------------TWFHGNLSGKEAEKLILERGKNGSFLVRESQSKPGD 245
            ::.||.                       .||||:|||||||||:.|:||:||||||||||.|||
Mouse    82 MEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGD 146

  Fly   246 FVLSVRTDD----------KVTHVMIRWQDKKYDVGGGESFGTLSELIDHYKRNPMVETCGTVVH 300
            |||||||.|          ||||||||.|:.||||||||.|.:|::|::|||:||||||.|||:.
Mouse   147 FVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQ 211

  Fly   301 LRQPFNATRITAAGINARVEQL---------VKGGFWEEFESL-QQDSRDTFSRNEGYKQENRLK 355
            |:||.|.|||.||.|.:||.:|         ||.|||||||:| ||:.:..:||.||.:|||:.|
Mouse   212 LKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNK 276

  Fly   356 NRYRNILPYDHTRVKLLDVEHSVAGAEYINANYIRLPTDGDLYNMSSSSESLNSSVPSCPACTAA 420
            |||:||||:|||||.|.|.:.:...::|||||.| :|
Mouse   277 NRYKNILPFDHTRVVLHDGDPNEPVSDYINANII-MP---------------------------- 312

  Fly   421 QTQRNCSNCQLQNKTCVQCAVKSAILPYSNCATCSRKSDSLSKHKRSESSASSSPSSGSGSGPGS 485
            :.:..|:|                                 ||.|
Mouse   313 EFETKCNN---------------------------------SKPK-------------------- 324

  Fly   486 SGTSGVSSVNGPGTPTNLTSGTAGCLVGLLKRHSNDSSGAVSISMAEREREREREMFKTYIATQG 550
                                                                     |:||||||
Mouse   325 ---------------------------------------------------------KSYIATQG 332

  Fly   551 CLLTQQVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQFGHARIQCVSENST 615
            ||    .|||.|||.||:|||:|||||||||.||||.||.:|||||...:::|..|::.|.|::.
Mouse   333 CL----QNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAA 393

  Fly   616 SDYTLREFLVS------WRDQPARRIFHYHFQVWPDHGVPADPGCVLNFLQDVNTRQSHLAQAGE 674
            .||||||..:|      .:....|.::.|||:.|||||||:|||.||:||::|:.:|..:..|
Mouse   394 HDYTLRELKLSKVGQALLQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIVDA-- 456

  Fly   675 KPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVY 739
              ||:.|||||||||||||||||:::|.|...|:|.:||:.:|||||||||||:|||||||:|:|
Mouse   457 --GPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIY 519

  Fly   740 YAVQHYIQTLIARKRAEEQSLQVGREYTNIKYTGEIGNDSQRSPLPPAISSISLVPSKTPLTPTS 804
            .||||||:||..|...|::|.:.|.|||||||:........:|||||.          || ||..
Mouse   520 MAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLVDQTSGDQSPLPPC----------TP-TPPC 573

  Fly   805 ADL 807
            |::
Mouse   574 AEM 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
csw	NP_477131.1	SH2_C-SH2_SHP_like	211..307	CDD:198185	72/105 (69%)
		PTPc	326..744	CDD:214550	163/424 (38%)
		PTPc	543..743	CDD:238006	118/205 (58%)
Ptpn11	NP_035332.1	SH2_N-SH2_SHP_like	5..103	CDD:198203	14/85 (16%)
		SH2_C-SH2_SHP_like	111..218	CDD:198185	72/106 (68%)
		PTPc-N11	272..528	CDD:350453	152/402 (38%)
		Substrate binding. /evidence=ECO:0000250	463..469		5/5 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	247	1.000	Domainoid score	I2155
eggNOG	1	0.900	-	-		E2759_KOG0790
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2122
Inparanoid	1	1.050	684	1.000	Inparanoid score	I708
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52365
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002703
OrthoInspector	1	1.000	-	-		otm42712
orthoMCL	1	0.900	-	-		OOG6_102716
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3129
SonicParanoid	1	1.000	-	-		X1404
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.760