Protein Alignment csw and M04G7.2

DIOPT Version :10

• Sequence 1: NP_477131.1
• Gene: csw / 45278
• FlyBaseID: FBgn0000382
• Length: 945
• Species: Drosophila melanogaster
• Sequence 2: NP_499934.1
• Gene: M04G7.2 / 187449
• WormBaseID: WBGene00019773
• Length: 550
• Species: Caenorhabditis elegans
• Alignment Length: 721
• Identity: 147/721 - (20%)
• Similarity: 235/721 - (32%)
• Gaps: 277/721 - (38%)

  Fly    85 RKAKVTPPTETPEAQEPA--CKNCMTHDELAQIIKGVAKGADAQRNRDNRLQRRRRPLSAQPSAA 147
            |||| ...|:.|||...:  .|:...:.:.....:...|.:|:.....::..||.:|:.. |:|:
 Worm     6 RKAK-QEVTKKPEASNGSKNSKSTFVNSKSPNQKRREVKKSDSDTESSHKNTRRTKPVPV-PAAS 68

  Fly   148 ASASTSTESLHR---------------LTPSPQASYPATPTSWTATPPQFPAAFGGASCSNSTLS 197
            :::..|.|...|               .:||.|      |.| |:|||          .|.....
 Worm    69 SNSKGSNEKHKRKSVQQVVKKVVNHIPFSPSKQ------PKS-TSTPP----------VSEGNRK 116

  Fly   198 LLATMRVQLHGYTWFHGNLSGKEAEKLILERGKN---------GSFLVRESQSKPGDFVLSVRT- 252
            .||...|.:        |....|.:..:.:...|         .:.|.|.:::.|..   :|:|
 Worm   117 RLAMADVSI--------NQLESEMDSFVKKIEPNERRATQYIHSNSLSRSNEAVPPG---NVKTS 170

  Fly   253 DDKVTHVMIRWQDKKYDVG-GGESFGTLSELIDHYKRNP--------MVETCGTVVHLRQPFNAT 308
            ..|..|.:||  ..:..:| .||:....|:..   |.:|        ...:..|...|.:  |::
 Worm   171 QQKADHHLIR--TTRSLIGLDGETEAVYSKAT---KASPDKGKLTADSPSSRRTSKSLEE--NSS 228

  Fly   309 RITAAGINARVEQLVKGGFWEEFESLQQDSRDTFSRNEGYKQE--------------------NR 353
            ..|...|:...::..:..:.:.|:.....|:.  ...:.:|||                    |.
 Worm   229 ETTNDSISLADDEETREAYRKLFKDFAMSSQK--MTLDDFKQEFSNLPGDPPSDLCTVFNHPVNN 291

  Fly   354 LKNRYRNILPYDHTRVKLLDVEHSVAGAEYINANYIRLPTDGDLYNMSSSSESLNSSVPSCPACT 418
            .||||.||...|.:||:|.....:....:||:|||||.|
 Worm   292 KKNRYSNIPCLDISRVQLKFKMPNKNSTDYIHANYIRSP-------------------------- 330

  Fly   419 AAQTQRNCSNCQLQNKTCVQCAVKSAILPYSNCATCSRKSDSLSKHKRSESSASSSPSSGSGSGP 483
                                                                             
 Worm   331 ----------------------------------------------------------------- 330

  Fly   484 GSSGTSGVSSVNGPGTPTNLTSGTAGCLVGLLKRHSNDSSGAVSISMAEREREREREMFKTYIAT 548
                                          .|||                          .||.|
 Worm   331 ------------------------------FLKR--------------------------GYILT 339

  Fly   549 QGCLLTQQVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQFGHARIQCVSEN 613
            ||    .:..|..|||.|:|||||..|||..:..|..:||||.|:|.....         |:..:
 Worm   340 QG----PKKETRADFWRMIWQENTTAIVMLCQFLETNREKCAEYFPRNAHC---------CLQFD 391

  Fly   614 STS----DYTLREFLVSWR-----DQPARRIFHYHFQVWPDHGVPADPGCVLNFLQDVNTRQSHL 669
            ..|    |.|:.:.||:.|     :...|.|.|:.::.|||..||.....:|..|:.:..|.:
 Worm   392 KFSVNYEDSTVNKSLVTTRLNLSYEGETRLITHWLWKEWPDWQVPESSEVMLKILRKIRARST-- 454

  Fly   670 AQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLDTEIDIQRTIQMVR-SQRSGLVQTEA 733
                    |..:|||||:||:||.:.:::.|..|..:  .|..||::.:..:| :.|:..|||..
 Worm   455 --------PPVIHCSAGVGRSGTLMAVEIALQSIHTH--FTLPDIKQIVSHLRVTGRAASVQTLQ 509

  Fly   734 QYKFVY 739
            ||..::
 Worm   510 QYMLIW 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
csw	NP_477131.1	SH2_C-SH2_SHP_like	211..307	CDD:198185	20/114 (18%)
		PTPc-N11_6	352..748	CDD:350392	87/398 (22%)
M04G7.2	NP_499934.1	PTZ00108	<9..242	CDD:240271	52/269 (19%)
		PTPc	266..520	CDD:214550	90/422 (21%)