Protein Alignment csw and Ptpn6

DIOPT Version :9

• Sequence 1: NP_477131.1
• Gene: csw / 45278
• FlyBaseID: FBgn0000382
• Length: 945
• Species: Drosophila melanogaster
• Sequence 2: NP_446360.2
• Gene: Ptpn6 / 116689
• RGDID: 620660
• Length: 597
• Species: Rattus norvegicus
• Alignment Length: 632
• Identity: 231/632 - (36%)
• Similarity: 308/632 - (48%)
• Gaps: 200/632 - (31%)

  Fly   190 SCSNSTLSLLATMRVQLHGYTWFHGNLSGKEAEKLILERGKNGSFLVRESQSKPGDFVLSVRTDD 254
            :||:.|            ...|:||::||.:||.|:..:|:..:||||||.|:||||||||..|.
  Rat   103 NCSDPT------------SERWYHGHMSGGQAESLLQAKGEPWTFLVRESLSQPGDFVLSVLNDQ 155

  Fly   255 ---------KVTHVMIRWQDKKYDVGGGESFGTLSELIDHYKRNPMVETCGTVVHLRQPFNATRI 310
                     :|||:.:..:..:|.|||.|:|.:|::|::|:|:..:.|..|..|:||||:.|||:
  Rat   156 PKAGPGSPLRVTHIKVMCEGGRYTVGGSETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRV 220

  Fly   311 TAAGINARV---------EQLVKGGFWEEFESLQ-QDSRDTFSRNEGYKQENRLKNRYRNILPYD 365
            .||.|..||         |...|.|||||||||| |:.::...|.||.:.||:.||||:||||:|
  Rat   221 NAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKSKNRYKNILPFD 285

  Fly   366 HTRVKLLDVEHSVAGAEYINANYIRLPTDGDLYNMSSSSESLNSSVPSCPACTAAQTQRNCSNCQ 430
            |:||.|...:.::.|::||||||
  Rat   286 HSRVILQGRDSNIPGSDYINANY------------------------------------------ 308

  Fly   431 LQNKTCVQCAVKSAILPYSNCATCSRKSDSLSKHKRSESSASSSPSSGSGSGPGSSGTSGVSSVN 495
                      ||:.:|
  Rat   309 ----------VKNQLL------------------------------------------------- 314

  Fly   496 GPGTPTNLTSGTAGCLVGLLKRHSNDSSGAVSISMAEREREREREMFKTYIATQGCLLTQQVNTV 560
            ||.                                         |..|||||:||||..    ||
  Rat   315 GPD-----------------------------------------ENSKTYIASQGCLDA----TV 334

  Fly   561 TDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQFGHARIQCVSENSTSDYTLREFLV 625
            .|||.|.||||||||||||:|.|:|:.||..|||:.|....:|...:....|:.|::|.||...:
  Rat   335 NDFWQMAWQENTRVIVMTTREVEKGRNKCVPYWPEVGTQRVYGLYSVTNCKEHDTAEYKLRTLQI 399

  Fly   626 SWRDQP--ARRIFHYHFQVWPDHGVPADPGCVLNFLQDVNTRQSHLAQAGEKPGPICVHCSAGIG 688
            |..|..  .|.|:||.:..|||||||::||.||:||..:|.||..|..|    |||.||||||||
  Rat   400 SPLDNGDLVREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHA----GPIIVHCSAGIG 460

  Fly   689 RTGTFIVIDMILDQIVRNGLDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYAVQHYIQTLIARK 753
            ||||.|||||:::.:...|||.:||||:||||||:||||:|||||||||:|.|:..:|:|  .:|
  Rat   461 RTGTIIVIDMLMESVSTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIET--TKK 523

  Fly   754 RAEEQSLQVGR--EYTNIKYTGEIGNDSQRSPLPPAISSISLVPSKT 798
            :.|....|.|:  ||.||.|             |||:.|.....|:|
  Rat   524 KLEIIQSQRGQESEYGNITY-------------PPALRSAHAKASRT 557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
csw	NP_477131.1	SH2_C-SH2_SHP_like	211..307	CDD:198185	45/104 (43%)
		PTPc	326..744	CDD:214550	156/420 (37%)
		PTPc	543..743	CDD:238006	114/201 (57%)
Ptpn6	NP_446360.2	SH2_N-SH2_SHP_like	6..103	CDD:198203	231/632 (37%)
		SH2_C-SH2_SHP_like	111..217	CDD:198185	45/105 (43%)
		PTPc-N6	255..520	CDD:350454	147/414 (36%)
		Substrate binding. /evidence=ECO:0000250	455..461		5/5 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	246	1.000	Domainoid score	I2105
eggNOG	1	0.900	-	-		E2759_KOG0790
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52365
OrthoDB	1	1.010	-	-		D132255at33208
OrthoFinder	1	1.000	-	-		FOG0002703
OrthoInspector	1	1.000	-	-		otm44777
orthoMCL	1	0.900	-	-		OOG6_102716
Panther	1	1.100	-	-	O	PTHR46257
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1404
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.790