Protein Alignment csw and PTPN21

DIOPT Version :10

• Sequence 1: NP_477131.1
• Gene: csw / 45278
• FlyBaseID: FBgn0000382
• Length: 945
• Species: Drosophila melanogaster
• Sequence 2: NP_008970.2
• Gene: PTPN21 / 11099
• HGNCID: 9651
• Length: 1174
• Species: Homo sapiens
• Alignment Length: 802
• Identity: 170/802 - (21%)
• Similarity: 262/802 - (32%)
• Gaps: 315/802 - (39%)

  Fly    18 VNHKLQE----------KQVYNNNNINNNNNNTLNNNNAYNNQRNFEYERAIQAHYGSKGRRSEE 72
            |.|.|||          .|::..|:|                      |.|..:| |.:|.|.:|
Human   613 VAHSLQEVSEPLTAARHAQLHKRNSI----------------------EVAGLSH-GLEGLRLKE 654

  Fly    73 RERSGKFKASKGRKAKVTPPTETPEAQEPACKNCMTHDELAQIIKGVAKG-----ADA------- 125
            |..|..       .|:|.|...:..:| |:.....|..|..:..:|:..|     :||
Human   655 RTLSAS-------AAEVAPRAVSVGSQ-PSVFTERTQREGPEEAEGLRYGHKKSLSDATMLIHSS 711

  Fly   126 QRNRDNRLQ------------RRRRPLSAQPSAAASASTSTESLHRLTPS---PQA------SYP 169
            :...|...:            |..||..||.............||.|.|.   |.|      |.|
Human   712 EEEEDEDFEEESGARAPPARAREPRPGLAQDPPGCPRVLLAGPLHILEPKAHVPDAEKRMMDSSP 776

  Fly   170 ATPTSWTATPPQFPAAFGGASCSNSTLSLLATMRVQLHGYTWFHGNLSGKEAEKLILERGKNGSF 234
            ...|:....|                               |..|.|....:|..:...|:..:
Human   777 VRTTAEAQRP-------------------------------WRDGLLMPSMSESDLTTSGRYRA- 809

  Fly   235 LVRES-QSKPGDFVLSVRTDDKVTHVMIRWQDKKYDVGGGESFGTLSEL-IDHYKRNPMVETCGT 297
             .|:| :.:|...:||               .||..|.|....|.:.:. :|..|..|:......
Human   810 -RRDSLKKRPVSDLLS---------------GKKNIVEGLPPLGGMKKTRVDAKKIGPLKLAALN 858

  Fly   298 VVHL-RQPFN------ATRIT----AAGINARVEQLVKGGFWEEFESLQQ----DSRDTFSRNEG 347
            .:.| |.|..      |||.|    ...:..|:||   |..:.|:|.:.:    |...:.:|
Human   859 GLSLSRVPLPDEGKEVATRATNDERCKILEQRLEQ---GMVFTEYERILKKRLVDGECSTAR--- 917

  Fly   348 YKQENRLKNRYRNILPYDHTRVKLLDVEHSVAGAEYINANYIRLPTDGDLYNMSSSSESLNSSVP 412
             ..||..:||::::||||..||:|:..:.:..|  ||||::|:
Human   918 -LPENAERNRFQDVLPYDDVRVELVPTKENNTG--YINASHIK---------------------- 957

  Fly   413 SCPACTAAQTQRNCSNCQLQNKTCVQCAVKSAILPYSNCATCSRKSDSLSKHKRSESSASSSPSS 477
                                                                             
Human   958 ----------------------------------------------------------------- 957

  Fly   478 GSGSGPGSSGTSGVSSVNGPGTPTNLTSGTAGCLVGLLKRHSNDSSGAVSISMAEREREREREMF 542
                                                            ||:|..|.:
Human   958 ------------------------------------------------VSVSGIEWD-------- 966

  Fly   543 KTYIATQGCLLTQQVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEG-RSEQFGHAR 606
              ||||||.|    .||..|||.|||::...:|.|.|.|.|.|:||..||||..| |.....:.|
Human   967 --YIATQGPL----QNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLGSRHNTVTYGR 1025

  Fly   607 IQCVSE-------NSTSDYTLREFLVSWRDQPARRIFHYHFQVWPDHGVPADPGCVLNFLQDVNT 664
            .:..:.       .:|:...::..|..    ..|.::|..:..||:||.|.|....|::|:::.:
Human  1026 FKITTRFRTDSGCYATTGLKMKHLLTG----QERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQS 1086

  Fly   665 RQSHLAQAGEKPG---PICVHCSAGIGRTGTFIVIDMILDQIVRNGLDTEIDIQRTIQMVRSQRS 726
            .:.|.....:...   |:.||||||:||||..|:.::::..:..|.:   :||.|.:.|:|.||.
Human  1087 VRRHTNSTSDPQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEV---LDIPRVLDMLRQQRM 1148

  Fly   727 GLVQTEAQYKFVYYAVQHYIQT 748
            .||||..||.|||..:..::::
Human  1149 MLVQTLCQYTFVYRVLIQFLKS 1170

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
csw	NP_477131.1	SH2_C-SH2_SHP_like	211..307	CDD:198185	21/104 (20%)
		PTPc-N11_6	352..748	CDD:350392	92/406 (23%)
PTPN21	NP_008970.2	FERM_F1_PTPN21	20..106	CDD:340712
		B41	24..222	CDD:214604
		FERM_C_PTPN14_PTPN21	217..307	CDD:270009
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	396..445
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	673..692		4/19 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	711..745		6/33 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	769..806		8/67 (12%)
		PTP_DSP_cys	883..1169	CDD:475123	101/450 (22%)