DRSC/TRiP Functional Genomics Resources

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Protein Alignment csw and PTPRU

DIOPT Version :10

Sequence 1:NP_477131.1 Gene:csw / 45278 FlyBaseID:FBgn0000382 Length:945 Species:Drosophila melanogaster
Sequence 2:NP_005695.3 Gene:PTPRU / 10076 HGNCID:9683 Length:1446 Species:Homo sapiens


Alignment Length:636 Identity:149/636 - (23%)
Similarity:222/636 - (34%) Gaps:259/636 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   268 YDVGGGESFGTLSE---LIDHYKRNPMVETC---GTVVHLRQPFNATRITAAGINARVEQL--VK 324
            |...|.:..|.::|   |:....|.|    |   |:..|..|...|.|:  |.:...:.|:  .:
Human   832 YSTRGDQRSGGVTEASSLLGGSPRRP----CGRKGSPYHTGQLHPAVRV--ADLLQHINQMKTAE 890

  Fly   325 G-GFWEEFESLQQDSRDTFSRNEGYKQENRLKNRYRNILP-YDHTRVKLLDVEHSVAG---AEYI 384
            | ||.:|:||.       |...:..|:::::|...:..:| ||..||||    |.:.|   |:||
Human   891 GYGFKQEYESF-------FEGWDATKKKDKVKGSRQEPMPAYDRHRVKL----HPMLGDPNADYI 944

  Fly   385 NANYIRLPTDGDLYNMSSSSESLNSSVPSCPACTAAQTQRNCSNCQLQNKTCVQCAVKSAILPYS 449
            |||||    ||  |:.|:.                                              
Human   945 NANYI----DG--YHRSNH---------------------------------------------- 957

  Fly   450 NCATCSRKSDSLSKHKRSESSASSSPSSGSGSGPGSSGTSGVSSVNGPGTPTNLTSGTAGCLVGL 514
                                                                             
Human   958 ----------------------------------------------------------------- 957

  Fly   515 LKRHSNDSSGAVSISMAEREREREREMFKTYIATQGCLLTQQVNTVTDFWNMVWQENTRVIVMTT 579
                                          :|||||    .:...|.|||.|||||:...|||.|
Human   958 ------------------------------FIATQG----PKPEMVYDFWRMVWQEHCSSIVMIT 988

  Fly   580 KEYERGKEKCARYWPDEGRSEQFGHARIQCVSENSTSDYTLREFLVSWRDQPAR-RIFHYHFQVW 643
            |..|.|:.||:||||::  |:.:|..:|..|...:.::|.:|.|.:..|...|| .:..:||..|
Human   989 KLVEVGRVKCSRYWPED--SDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAW 1051

  Fly   644 PDHGVPADPGCVLNFLQDVNTRQSHLAQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGL 708
            |:||||.....:|.|::.|.      |......|||.:|||||.||||.:||:|::||.....|:
Human  1052 PEHGVPYHATGLLAFIRRVK------ASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGV 1110

  Fly   709 DTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYA-------------VQHYIQTLIARKRAEEQ-- 758
               :||...::.:.|:|..::|||.||.|::.|             |..:..|.....|.:.|  
Human  1111 ---VDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSN 1172

  Fly   759 SLQVGREYTNIKYTGEIGNDSQRSPLPPAISSISLVPSKTPLTPTSADLGTGMGLSMGVGMGVGN 823
            |.|:..|:..:        :|...||.....||:|:|.                          |
Human  1173 SSQLREEFQTL--------NSVTPPLDVEECSIALLPR--------------------------N 1203

  Fly   824 KHASKQQPPLPVVNCNNNNNGIGNSGCSNGGGSSTTSSSNGSSNGNINALL 874
            :..::....||...|                 .....|::|.||..|||.|
Human  1204 RDKNRSMDVLPPDRC-----------------LPFLISTDGDSNNYINAAL 1237

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cswNP_477131.1 SH2_C-SH2_SHP_like 211..307 CDD:198185 11/44 (25%)
PTPc-N11_6 352..748 CDD:350392 101/413 (24%)
PTPRUNP_005695.3 MAM 22..186 CDD:214533
fn3 291..365 CDD:394996
FN3 <347..>624 CDD:442628
fn3 494..577 CDD:394996
Mediates interaction with CTNNB1. /evidence=ECO:0000250 771..887 15/60 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 833..861 7/31 (23%)
R-PTPc-U-1 943..1147 CDD:350480 89/365 (24%)
R-PTPc-U-2 1232..1438 CDD:350485 4/6 (67%)
Blue background indicates that the domain is not in the aligned region.

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