Protein Alignment csw and ptpn6

DIOPT Version :10

• Sequence 1: NP_477131.1
• Gene: csw / 45278
• FlyBaseID: FBgn0000382
• Length: 945
• Species: Drosophila melanogaster
• Sequence 2: NP_001116928.1
• Gene: ptpn6 / 100144699
• XenbaseID: XB-GENE-487863
• Length: 589
• Species: Xenopus tropicalis
• Alignment Length: 610
• Identity: 219/610 - (35%)
• Similarity: 304/610 - (49%)
• Gaps: 179/610 - (29%)

  Fly   187 GGASCSNSTLSLLATMRVQLH-----GYTWFHGNLSGKEAEKLILERGKNGSFLVRESQSKPGDF 246
            |.|.|...|......::..|:     ...|:||.|||.:||||:.:.|:..:||||||:|.||||
 Frog    81 GQAECLQDTSGNRIELKYPLNCSDPTNERWYHGYLSGPDAEKLLQKTGEPWTFLVRESRSNPGDF 145

  Fly   247 VLSVRTDD------KVTHVMIRWQDKK--YDVGGGESFGTLSELIDHYKRNPMVETCGTVVHLRQ 303
            |:|:.|.:      |||||.|..:..|  |:: |.|.|.:|::||:.:|:.|:.|..|:.:.|::
 Frog   146 VISILTPEQKDGVHKVTHVKINTEKNKDTYNI-GREKFESLTDLIEWHKKKPIEEATGSHLFLKK 209

  Fly   304 PFNATRITAAGINARVEQL---------VKGGFWEEFESLQ-QDSRDTFSRNEGYKQENRLKNRY 358
            |..:||:.||.|..|:::|         .|.||||||::|| |:::....|.||.:.||:.||||
 Frog   210 PCYSTRVNAADIENRMKELNKKSEQDEAAKAGFWEEFDALQKQENKVHNDRKEGQRPENKSKNRY 274

  Fly   359 RNILPYDHTRVKLLDVEHSVAGAEYINANYIRLPTDGDLYNMSSSSESLNSSVPSCPACTAAQTQ 423
            :||||||||||.|...:::..|::||||||:.
 Frog   275 KNILPYDHTRVILKCGDNNTPGSDYINANYVN--------------------------------- 306

  Fly   424 RNCSNCQLQNKTCVQCAVKSAILPYSNCATCSRKSDSLSKHKRSESSASSSPSSGSGSGPGSSGT 488
                                                                             
 Frog   307 ----------------------------------------------------------------- 306

  Fly   489 SGVSSVNGPGTPTNLTSGTAGCLVGLLKRHSNDSSGAVSISMAEREREREREMFKTYIATQGCLL 553
                                                  ::..||.|..      |.:||.||||
 Frog   307 --------------------------------------NLLWAEGEPP------KRFIACQGCL- 326

  Fly   554 TQQVNTVT-DFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRS-EQFGHARIQCVSENSTS 616
                |:.| |||.||||||:|||||||||.|:|:.||..||||.|.: ::||...:|.:||..|.
 Frog   327 ----NSTTGDFWEMVWQENSRVIVMTTKEIEKGRTKCVPYWPDVGTNMKEFGRFLVQLMSERDTK 387

  Fly   617 DYTLREFLVSWRD--QPARRIFHYHFQVWPDHGVPADPGCVLNFLQDVNTRQSHLAQAGEKPGPI 679
            :|.:|...||..:  :.:|.|.||.:..|||||||||||.||:||::||:.|..:.:|    |.|
 Frog   388 EYKVRLLRVSLTESTEKSRDIHHYQYLTWPDHGVPADPGGVLSFLEEVNSMQESMPRA----GAI 448

  Fly   680 CVHCSAGIGRTGTFIVIDMILDQIVRNGLDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYAVQH 744
            .||||||||||||.|.|||:||.|...|:|::||:|:||||||:||||:|||||||||:|.|:..
 Frog   449 VVHCSAGIGRTGTIIAIDMLLDLIQMKGVDSDIDVQKTIQMVRNQRSGMVQTEAQYKFIYSAIAQ 513

  Fly   745 YIQTLIARKRAEEQSLQVGREYTNI 769
            :|.:...:.:|.|.......||.|:
 Frog   514 FIDSTKHKLKAMENRNATESEYGNL 538

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
csw	NP_477131.1	SH2_C-SH2_SHP_like	211..307	CDD:198185	45/103 (44%)
		PTPc-N11_6	352..748	CDD:350392	143/399 (36%)
ptpn6	NP_001116928.1	SH2_N-SH2_SHP_like	3..101	CDD:198203	4/19 (21%)
		SH2_C-SH2_SHP_like	109..213	CDD:198185	45/104 (43%)
		PTP_DSP_cys	251..517	CDD:475123	148/416 (36%)