DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prosbeta5 and PRE2

DIOPT Version :9

Sequence 1:	NP_652014.1	Gene:	Prosbeta5 / 45269	FlyBaseID:	FBgn0029134	Length:	282	Species:	Drosophila melanogaster
Sequence 2:	NP_015428.1	Gene:	PRE2 / 856218	SGDID:	S000006307	Length:	287	Species:	Saccharomyces cerevisiae

Alignment Length:	236	Identity:	127/236 - (53%)
Similarity:	170/236 - (72%)	Gaps:	1/236 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 TLAAPPFENPLHNLNQIQANGDKTGVKINFDHGTTTLGFKFKGGVLLAVDSRATGGSYIGSQSMK 105
            :|..||..:|...|.....:......||...||||||.|:|:||:::|||||||.|:::.||::|
Yeast    43 SLTVPPIASPQQFLRAHTDDSRNPDCKIKIAHGTTTLAFRFQGGIIVAVDSRATAGNWVASQTVK 107

  Fly   106 KIVEINQFMLGTLAGGAADCVYWDRVLSKECRLHELRNKERISVAAASKIMANIAHEYKGMGLSM 170
            |::|||.|:|||:|||||||.:|:..|..:|||||||.||||||||||||::|:.::|||.||||
Yeast   108 KVIEINPFLLGTMAGGAADCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSM 172

  Fly   171 GMMLAGYD-KRGPGLYYVDSEGSRTPGNLFSVGSGSLYAYGVLDSGYHWDLEDKEAQELGRRAIY 234
            |.|:.||. |.||.:|||||:|:|..|::|.||||..:|||||||.|.|||..::|..||:|:|.
Yeast   173 GTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSIL 237

  Fly   235 HATFRDAYSGGIIRVYHIKEDGWVNISNTDCMELHYMYQEQ 275
            .|..|||||||.:.:||:.||||:...|.|..||.:..:|:
Yeast   238 AAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEE 278

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prosbeta5	NP_652014.1	PTZ00488	38..272	CDD:185666	126/231 (55%)
Prosbeta5	NP_652014.1	proteasome_beta_type_5	74..261	CDD:239730	113/187 (60%)
PRE2	NP_015428.1	proteasome_beta_type_5	76..264	CDD:239730	113/187 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343643
Domainoid	1	1.000	244	1.000	Domainoid score	I368
eggNOG	1	0.900	-	-		E1_COG0638
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	270	1.000	Inparanoid score	I601
Isobase	1	0.950	-	0	Normalized mean entropy	S454
OMA	1	1.010	-	-		QHG53702
OrthoFinder	1	1.000	-	-		FOG0001305
OrthoInspector	1	1.000	-	-		otm46594
orthoMCL	1	0.900	-	-		OOG6_100897
Panther	1	1.100	-	-	LDO	PTHR11599
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1013
SonicParanoid	1	1.000	-	-		X647
TreeFam	1	0.960	-	-
	15	14.740