DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prosbeta5 and PSMB5

DIOPT Version :9

Sequence 1:	NP_652014.1	Gene:	Prosbeta5 / 45269	FlyBaseID:	FBgn0029134	Length:	282	Species:	Drosophila melanogaster
Sequence 2:	NP_002788.1	Gene:	PSMB5 / 5693	HGNCID:	9542	Length:	263	Species:	Homo sapiens

Alignment Length:	238	Identity:	137/238 - (57%)
Similarity:	190/238 - (79%)	Gaps:	13/238 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 NLANPYTLAAPPFENPLHNLNQIQANGDKTGVKINFDHGTTTLGFKFKGGVLLAVDSRATGGSYI 99
            :|::..:||||.:..|           ::.|:::.  ||||||.|||:.||::|.|||||.|:||
Human    34 SLSDGLSLAAPGWGVP-----------EEPGIEML--HGTTTLAFKFRHGVIVAADSRATAGAYI 85

  Fly   100 GSQSMKKIVEINQFMLGTLAGGAADCVYWDRVLSKECRLHELRNKERISVAAASKIMANIAHEYK 164
            .||::||::|||.::|||:|||||||.:|:|:|:::||::|||||||||||||||::||:.::||
Human    86 ASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYK 150

  Fly   165 GMGLSMGMMLAGYDKRGPGLYYVDSEGSRTPGNLFSVGSGSLYAYGVLDSGYHWDLEDKEAQELG 229
            |||||||.|:.|:||||||||||||||:|..|..|||||||:|||||:|.||.:|||.::|.:|.
Human   151 GMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLA 215

  Fly   230 RRAIYHATFRDAYSGGIIRVYHIKEDGWVNISNTDCMELHYMY 272
            |||||.||:|||||||.:.:||::||||:.:|:.:..:||..|
Human   216 RRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHEKY 258

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prosbeta5	NP_652014.1	PTZ00488	38..272	CDD:185666	135/233 (58%)
Prosbeta5	NP_652014.1	proteasome_beta_type_5	74..261	CDD:239730	124/186 (67%)
PSMB5	NP_002788.1	proteasome_beta_type_5	60..247	CDD:239730	124/186 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	273	1.000	Domainoid score	I1789
eggNOG	1	0.900	-	-		E1_COG0638
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55690
Inparanoid	1	1.050	295	1.000	Inparanoid score	I2756
Isobase	1	0.950	-	0	Normalized mean entropy	S454
OMA	1	1.010	-	-		QHG53702
OrthoDB	1	1.010	-	-		D396507at33208
OrthoFinder	1	1.000	-	-		FOG0001305
OrthoInspector	1	1.000	-	-		mtm8519
orthoMCL	1	0.900	-	-		OOG6_100897
Panther	1	1.100	-	-	LDO	PTHR11599
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1013
SonicParanoid	1	1.000	-	-		X647
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.820