DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prosbeta5 and Prosbeta5R1

DIOPT Version :9

Sequence 1:	NP_652014.1	Gene:	Prosbeta5 / 45269	FlyBaseID:	FBgn0029134	Length:	282	Species:	Drosophila melanogaster
Sequence 2:	NP_611776.1	Gene:	Prosbeta5R1 / 37690	FlyBaseID:	FBgn0034842	Length:	315	Species:	Drosophila melanogaster

Alignment Length:	277	Identity:	167/277 - (60%)
Similarity:	210/277 - (75%)	Gaps:	12/277 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MALAEICKISNAPYMR-----PNAWSSADVEEEQKGLMCNLANPYTLAAPPFENPLHNLNQIQAN 60
            |||..||.::..|:||     .:.|.    :|:.:....|..|||.|.|||||.|..||.:|.::
  Fly     1 MALEAICGMNKMPFMRRFDDLQSEWQ----KEQLREATSNFENPYELMAPPFERPAENLPKILSH 61

  Fly    61 GDKTGVKINFDHGTTTLGFKFKGGVLLAVDSRATGGSYIGSQSMKKIVEINQFMLGTLAGGAADC 125
               .|::::|||||||||||::|||:|..|||||.|.|||||:|:||||:|.:||||||||||||
  Fly    62 ---CGIRMDFDHGTTTLGFKYRGGVILCADSRATSGQYIGSQTMRKIVELNDYMLGTLAGGAADC 123

  Fly   126 VYWDRVLSKECRLHELRNKERISVAAASKIMANIAHEYKGMGLSMGMMLAGYDKRGPGLYYVDSE 190
            |||||||:||||||:||.::|::|..|::|:.||:.|||||||.|||||||:|..||.|.|||||
  Fly   124 VYWDRVLAKECRLHQLRYRKRMTVDTAARIICNISTEYKGMGLVMGMMLAGFDDEGPKLIYVDSE 188

  Fly   191 GSRTPGNLFSVGSGSLYAYGVLDSGYHWDLEDKEAQELGRRAIYHATFRDAYSGGIIRVYHIKED 255
            |.|:.|.:|||||||.||.||||:||.:||.|:||.:|.||||||||.:|||||||:|:|||..:
  Fly   189 GMRSHGQVFSVGSGSPYALGVLDTGYRYDLSDQEAYDLARRAIYHATSKDAYSGGIVRLYHIHSE 253

  Fly   256 GWVNISNTDCMELHYMY 272
            ||.||.||||.:||..|
  Fly   254 GWRNICNTDCSDLHDSY 270

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prosbeta5	NP_652014.1	PTZ00488	38..272	CDD:185666	155/233 (67%)
Prosbeta5	NP_652014.1	proteasome_beta_type_5	74..261	CDD:239730	130/186 (70%)
Prosbeta5R1	NP_611776.1	PTZ00488	39..272	CDD:185666	156/235 (66%)
Prosbeta5R1	NP_611776.1	proteasome_beta_type_5	72..259	CDD:239730	130/186 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45448426
Domainoid	1	1.000	254	1.000	Domainoid score	I500
eggNOG	1	0.900	-	-		E1_COG0638
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I897
Isobase	1	0.950	-	0	Normalized mean entropy	S454
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D396507at33208
OrthoFinder	1	1.000	-	-		FOG0001305
OrthoInspector	1	1.000	-	-		mtm6525
orthoMCL	1	0.900	-	-		OOG6_100897
Panther	1	1.100	-	-	P	PTHR11599
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1013
SonicParanoid	1	1.000	-	-		X647
	13	12.780