DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prosbeta5 and PSMB11

DIOPT Version :9

Sequence 1:	NP_652014.1	Gene:	Prosbeta5 / 45269	FlyBaseID:	FBgn0029134	Length:	282	Species:	Drosophila melanogaster
Sequence 2:	NP_001093250.1	Gene:	PSMB11 / 122706	HGNCID:	31963	Length:	300	Species:	Homo sapiens

Alignment Length:	279	Identity:	111/279 - (39%)
Similarity:	169/279 - (60%)	Gaps:	24/279 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MALAEICKISNAPYMRPNAWSSADVEEEQKGLMCNLANPYTLAAPPFENPLHNLNQIQANGDKTG 65
            |||.::||           |.|.|.:    |...:|......|.|...:|   ...:|.:|.:..
Human     1 MALQDVCK-----------WQSPDTQ----GPSPHLPRAGGWAVPRGCDP---QTFLQIHGPRLA 47

  Fly    66 VKINFDHGTTTLGFKFKGGVLLAVDSRATGGSYIGSQSMKKIVEINQFMLGTLAGGAADCVYWDR 130
                  ||||||.|:|:.||:.|.|:|::.|||:...:..|::.::|.:|||.:|.:|||..|.|
Human    48 ------HGTTTLAFRFRHGVIAAADTRSSCGSYVACPASCKVIPVHQHLLGTTSGTSADCATWYR 106

  Fly   131 VLSKECRLHELRNKERISVAAASKIMANIAHEYKGMGLSMGMMLAGYDKRGPGLYYVDSEGSRTP 195
            ||.:|.||.|||..:..|||:|:|:::.:..:|:|:.|.:...|.|:|:.||.|:||.|:|:|..
Human   107 VLQRELRLRELREGQLPSVASAAKLLSAMMSQYRGLDLCVATALCGWDRSGPELFYVYSDGTRLQ 171

  Fly   196 GNLFSVGSGSLYAYGVLDSGYHWDLEDKEAQELGRRAIYHATFRDAYSGGIIRVYHIKEDGWVNI 260
            |::|||||||.|||||||.||.:|:..:||..|.|.|:.|||.|||||||.:.::|::|.||.::
Human   172 GDIFSVGSGSPYAYGVLDRGYRYDMSTQEAYALARCAVAHATHRDAYSGGSVDLFHVRESGWEHV 236

  Fly   261 SNTDCMELHYMYQEQLKQQ 279
            |.:|...|:...|:.|:.:
Human   237 SRSDACVLYVELQKLLEPE 255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prosbeta5	NP_652014.1	PTZ00488	38..272	CDD:185666	99/233 (42%)
Prosbeta5	NP_652014.1	proteasome_beta_type_5	74..261	CDD:239730	89/186 (48%)
PSMB11	NP_001093250.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23		10/36 (28%)
		proteasome_beta_type_5	50..237	CDD:239730	89/186 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	255..300		0/1 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0638
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D396507at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11599
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X647
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.880