Protein Alignment cathD and NAPSA

DIOPT Version :9

• Sequence 1: NP_001334713.1
• Gene: cathD / 45268
• FlyBaseID: FBgn0029093
• Length: 392
• Species: Drosophila melanogaster
• Sequence 2: NP_004842.1
• Gene: NAPSA / 9476
• HGNCID: 13395
• Length: 420
• Species: Homo sapiens
• Alignment Length: 413
• Identity: 197/413 - (47%)
• Similarity: 256/413 - (61%)
• Gaps: 38/413 - (9%)

  Fly     1 MQKVALLLVAFLAAAVAHPNSQEKPG---LLRVPLHKFQSARRHFADVGTELQQLR--------I 54
            :|.:.|||          |....:|.   |:|:|||:.|..||       .|..||        .
Human     7 LQPLLLLL----------PLLNVEPSGATLIRIPLHRVQPGRR-------ILNLLRGWREPAELP 54

  Fly    55 RYGG---GDVP--EPLSNYMDAQYYGPIAIGSPPQNFRVVFDTGSSNLWVPSKKCHLTNIACLMH 114
            :.|.   ||.|  .|||||.|.||:|.|.:|:|||||.|.||||||||||||::||..::.|.:|
Human    55 KLGAPSPGDKPIFVPLSNYRDVQYFGEIGLGTPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWLH 119

  Fly   115 NKYDASKSKTYTKNGTEFAIQYGSGSLSGYLSTDTVSIAGLDIKDQTFAEALSEPGLVFVAAKFD 179
            :::|...|.::..|||:||||||:|.:.|.||.|.::|.|:......|.|||.||.|||..|.||
Human   120 HRFDPKASSSFQANGTKFAIQYGTGRVDGILSEDKLTIGGIKGASVIFGEALWEPSLVFAFAHFD 184

  Fly   180 GILGLGYNSISVDKVKPPFYAMYEQGLISAPVFSFYLNRDPASPEGGEIIFGGSDPNHYTGEFTY 244
            ||||||:..:||:.|:||...:.||||:..|||||||||||..|:|||::.|||||.||....|:
Human   185 GILGLGFPILSVEGVRPPMDVLVEQGLLDKPVFSFYLNRDPEEPDGGELVLGGSDPAHYIPPLTF 249

  Fly   245 LPVTRKAYWQIKMDAASIG-DLQLCKGGCQVIADTGTSLIAAPLEEATSINQKIGGTPIIGGQYV 308
            :|||..|||||.|:...:| .|.||..||..|.|||||||..|.||..:::..|||.|::.|:|:
Human   250 VPVTVPAYWQIHMERVKVGPGLTLCAKGCAAILDTGTSLITGPTEEIRALHAAIGGIPLLAGEYI 314

  Fly   309 VSCDLIPQLPVIKFVLGGKTFELEGKDYILRVAQMGKTICLSGFMGLDIPPPNGPLWILGDVFIG 373
            :.|..||:||.:.|:|||..|.|...||:::..:.|..:|||||..||:|||.||.|||||||:|
Human   315 ILCSEIPKLPAVSFLLGGVWFNLTAHDYVIQTTRNGVRLCLSGFQALDVPPPAGPFWILGDVFLG 379

  Fly   374 KYYTEFDMG----NDRVGFADAK 392
            .|...||.|    :.|||.|.|:
Human   380 TYVAVFDRGDMKSSARVGLARAR 402

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cathD	NP_001334713.1	None
NAPSA	NP_004842.1	pepsin_retropepsin_like	72..399	CDD:299705	171/326 (52%)
		Asp	77..401	CDD:278455	169/323 (52%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100536
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3883
SonicParanoid	1	1.000	-	-		X163
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.820