DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cathD and PEP4

DIOPT Version :9

Sequence 1:	NP_001334713.1	Gene:	cathD / 45268	FlyBaseID:	FBgn0029093	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	NP_015171.1	Gene:	PEP4 / 855949	SGDID:	S000006075	Length:	405	Species:	Saccharomyces cerevisiae

Alignment Length:	415	Identity:	184/415 - (44%)
Similarity:	240/415 - (57%)	Gaps:	47/415 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VALLLV-AFLAAAVAHPNSQEKPGLLRVPLHKFQ--------SARRHFADVG----TELQQLR-- 53
            :||||| |...||..|          :..::|.:        :..:|.|.:|    |:.::..
Yeast    10 LALLLVSANQVAAKVH----------KAKIYKHELSDEMKEVTFEQHLAHLGQKYLTQFEKANPE 64

  Fly    54 ---------IRYGGGDVPEPLSNYMDAQYYGPIAIGSPPQNFRVVFDTGSSNLWVPSKKCHLTNI 109
                     ...||.||  ||:||::||||..|.:|:|||||:|:.|||||||||||.:|  .::
Yeast    65 VVFSREHPFFTEGGHDV--PLTNYLNAQYYTDITLGTPPQNFKVILDTGSSNLWVPSNEC--GSL 125

  Fly   110 ACLMHNKYDASKSKTYTKNGTEFAIQYGSGSLSGYLSTDTVSIAGLDIKDQTFAEALSEPGLVFV 174
            ||.:|:|||...|.:|..||||||||||:|||.||:|.||:||..|.|..|.||||.|||||.|.
Yeast   126 ACFLHSKYDHEASSSYKANGTEFAIQYGTGSLEGYISQDTLSIGDLTIPKQDFAEATSEPGLTFA 190

  Fly   175 AAKFDGILGLGYNSISVDKVKPPFYAMYEQGLISAPVFSFYLNRDPASPE-GGEIIFGGSDPNHY 238
            ..||||||||||::||||||.||||...:|.|:....|:|||.......| |||..|||.|.:.:
Yeast   191 FGKFDGILGLGYDTISVDKVVPPFYNAIQQDLLDEKRFAFYLGDTSKDTENGGEATFGGIDESKF 255

  Fly   239 TGEFTYLPVTRKAYWQIKMDAASIGD--LQLCKGGCQVIADTGTSLIAAPLEEATSINQKIGGTP 301
            .|:.|:|||.|||||::|.:...:||  .:|...|..:  |||||||..|...|..||.:||...
Yeast   256 KGDITWLPVRRKAYWEVKFEGIGLGDEYAELESHGAAI--DTGTSLITLPSGLAEMINAEIGAKK 318

  Fly   302 IIGGQYVVSCDLIPQLPVIKFVLGGKTFELEGKDYILRVAQMGKTICLSGFMGLDIPPPNGPLWI 366
            ...|||.:.|:....||.:.|...|..|.:...||.|.|:..    |:|....:|.|.|.|||.|
Yeast   319 GWTGQYTLDCNTRDNLPDLIFNFNGYNFTIGPYDYTLEVSGS----CISAITPMDFPEPVGPLAI 379

  Fly   367 LGDVFIGKYYTEFDMGNDRVGFADA 391
            :||.|:.|||:.:|:||:.||.|.|
Yeast   380 VGDAFLRKYYSIYDLGNNAVGLAKA 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cathD	NP_001334713.1	None
PEP4	NP_015171.1	Proteinase_A_fungi	81..403	CDD:133155	165/331 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	303	1.000	Domainoid score	I215
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55616
Inparanoid	1	1.050	319	1.000	Inparanoid score	I453
Isobase	1	0.950	-	0	Normalized mean entropy	S917
OMA	1	1.010	-	-		QHG54317
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	1	1.000	-	-		otm46649
orthoMCL	1	0.900	-	-		OOG6_100536
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3883
SonicParanoid	1	1.000	-	-		X163
TreeFam	1	0.960	-	-
	15	14.810