Protein Alignment cathD and PGA4

DIOPT Version :10

• Sequence 1: NP_652013.1
• Gene: cathD / 45268
• FlyBaseID: FBgn0029093
• Length: 392
• Species: Drosophila melanogaster
• Sequence 2: NP_001073276.1
• Gene: PGA4 / 643847
• HGNCID: 8886
• Length: 388
• Species: Homo sapiens
• Alignment Length: 377
• Identity: 156/377 - (41%)
• Similarity: 218/377 - (57%)
• Gaps: 22/377 - (5%)

  Fly    27 LLRVPLHKFQSARRHFADVGT--------ELQQLRIRYGGGDVP-----EPLSNYMDAQYYGPIA 78
            :.:|||.:.:|.||..::.|.        .|...|..:...:.|     :||.||:|.:|:|.|.
Human    17 MYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWEAPTLVDEQPLENYLDMEYFGTIG 81

  Fly    79 IGSPPQNFRVVFDTGSSNLWVPSKKCHLTNIACLMHNKYDASKSKTYTKNGTEFAIQYGSGSLSG 143
            ||:|.|:|.||||||||||||||..|  :::||..||:::...|.||.......:|.||:||::|
Human    82 IGTPAQDFTVVFDTGSSNLWVPSVYC--SSLACTNHNRFNPEDSSTYQSTSETVSITYGTGSMTG 144

  Fly   144 YLSTDTVSIAGLDIKDQTFAEALSEPGLVFVAAKFDGILGLGYNSISVDKVKPPFYAMYEQGLIS 208
            .|..|||.:.|:...:|.|..:.:|||.....|.|||||||.|.|||.....|.|..::.|||:|
Human   145 ILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFDGILGLAYPSISSSGATPVFDNIWNQGLVS 209

  Fly   209 APVFSFYLNRDPASPEGGEIIFGGSDPNHYTGEFTYLPVTRKAYWQIKMDAASI-GDLQLCKGGC 272
            ..:||.||:.|..|  |..:||||.|.::|||...::|||.:.||||.:|:.:: |:...|..||
Human   210 QDLFSVYLSADDQS--GSVVIFGGIDSSYYTGSLNWVPVTVEGYWQITVDSITMNGEAIACAEGC 272

  Fly   273 QVIADTGTSLIAAPLEEATSINQKIGGTPIIGGQYVVSCDLIPQLPVIKFVLGGKTFELEGKDYI 337
            |.|.||||||:..|.....:|...||.:....|..||||..|..||.|.|.:.|..:.:....||
Human   273 QAIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYI 337

  Fly   338 LRVAQMGKTICLSGFMGLDIPPPNGPLWILGDVFIGKYYTEFDMGNDRVGFA 389
            |:    .:..|:|||.|:::|..:|.|||||||||.:|:|.||..|::||.|
Human   338 LQ----SEGSCISGFQGMNLPTESGELWILGDVFIRQYFTVFDRANNQVGLA 385

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cathD	NP_652013.1	A1_Propeptide	29..56	CDD:462326	9/34 (26%)
		pepsin_retropepsin_like	62..389	CDD:472175	146/332 (44%)
PGA4	NP_001073276.1	A1_Propeptide	19..45	CDD:462326	7/25 (28%)
		pepsin_A	66..386	CDD:133145	146/328 (45%)