DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cathD and PGA3

DIOPT Version :9

Sequence 1:	NP_001334713.1	Gene:	cathD / 45268	FlyBaseID:	FBgn0029093	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	NP_001073275.1	Gene:	PGA3 / 643834	HGNCID:	8885	Length:	388	Species:	Homo sapiens

Alignment Length:	377	Identity:	156/377 - (41%)
Similarity:	217/377 - (57%)	Gaps:	22/377 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LLRVPLHKFQSARRHFADVGT--------ELQQLRIRYGGGDVP-----EPLSNYMDAQYYGPIA 78
            :.:|||.:.:|.||..::.|.        .|...|..:.....|     :||.||:|.:|:|.|.
Human    17 MYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWKAPTLVDEQPLENYLDMEYFGTIG 81

  Fly    79 IGSPPQNFRVVFDTGSSNLWVPSKKCHLTNIACLMHNKYDASKSKTYTKNGTEFAIQYGSGSLSG 143
            ||:|.|:|.||||||||||||||..|  :::||..||:::...|.||.......:|.||:||::|
Human    82 IGTPAQDFTVVFDTGSSNLWVPSVYC--SSLACTNHNRFNPEDSSTYQSTSETVSITYGTGSMTG 144

  Fly   144 YLSTDTVSIAGLDIKDQTFAEALSEPGLVFVAAKFDGILGLGYNSISVDKVKPPFYAMYEQGLIS 208
            .|..|||.:.|:...:|.|..:.:|||.....|.|||||||.|.|||.....|.|..::.|||:|
Human   145 ILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFDGILGLAYPSISSSGATPVFDNIWNQGLVS 209

  Fly   209 APVFSFYLNRDPASPEGGEIIFGGSDPNHYTGEFTYLPVTRKAYWQIKMDAASI-GDLQLCKGGC 272
            ..:||.||:.|..|  |..:||||.|.::|||...::|||.:.||||.:|:.:: |:...|..||
Human   210 QDLFSVYLSADDQS--GSVVIFGGIDSSYYTGSLNWVPVTVEGYWQITVDSITMNGEAIACAEGC 272

  Fly   273 QVIADTGTSLIAAPLEEATSINQKIGGTPIIGGQYVVSCDLIPQLPVIKFVLGGKTFELEGKDYI 337
            |.|.||||||:..|.....:|...||.:....|..||||..|..||.|.|.:.|..:.:....||
Human   273 QAIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYI 337

  Fly   338 LRVAQMGKTICLSGFMGLDIPPPNGPLWILGDVFIGKYYTEFDMGNDRVGFA 389
            |:    .:..|:|||.|:::|..:|.|||||||||.:|:|.||..|::||.|
Human   338 LQ----SEGSCISGFQGMNLPTESGELWILGDVFIRQYFTVFDRANNQVGLA 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cathD	NP_001334713.1	None
PGA3	NP_001073275.1	A1_Propeptide	17..45	CDD:285240	7/27 (26%)
		pepsin_A	66..386	CDD:133145	146/328 (45%)
		Asp	75..387	CDD:278455	141/319 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.930