DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cathD and Pga5

DIOPT Version :9

Sequence 1:	NP_001334713.1	Gene:	cathD / 45268	FlyBaseID:	FBgn0029093	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	NP_067428.2	Gene:	Pga5 / 58803	MGIID:	1915935	Length:	387	Species:	Mus musculus

Alignment Length:	385	Identity:	148/385 - (38%)
Similarity:	215/385 - (55%)	Gaps:	34/385 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LLRVPLHKFQSARRHFAD---------------VGTELQQLR---IRYGGGDVPEPLSNYMDAQY 73
            |:::||.|.:|.|.:..:               ....|:|.|   :.|      ||:.||:|..|
Mouse    16 LVKIPLMKIKSMRENLRESQVLKDYLEKYPRSRAHVLLEQRRNPAVTY------EPMRNYLDLVY 74

  Fly    74 YGPIAIGSPPQNFRVVFDTGSSNLWVPSKKCHLTNIACLMHNKYDASKSKTYTKNGTEFAIQYGS 138
            .|.|:||:|||.||||.|||||.|||||..|  ::.||..|..::..:|.|:..:|....:.|||
Mouse    75 IGIISIGTPPQEFRVVLDTGSSVLWVPSIYC--SSPACAHHKAFNPLRSSTFLVSGRPVNVAYGS 137

  Fly   139 GSLSGYLSTDTVSIAGLDIKDQTFAEALSEPGLVFVAAKFDGILGLGYNSISVDKVKPPFYAMYE 203
            |.:||:|:.|||.|..|.:..|.|..:|.|||:....|.|||||||||.::.:..:.|.|..::.
Mouse   138 GEMSGFLAYDTVRIGDLTVVAQAFGLSLEEPGIFMEYAVFDGILGLGYPNLGLQGITPVFDNLWL 202

  Fly   204 QGLISAPVFSFYLNRDPASPEGGEIIFGGSDPNHYTGEFTYLPVTRKAYWQIKMDAASI-GDLQL 267
            ||||...:|:|||:  ....:|..::.||.||::|.||..::||::.:|||:.:|:.|: |::..
Mouse   203 QGLIPQNLFAFYLS--SKDEKGSMLMLGGVDPSYYHGELHWVPVSKPSYWQLAVDSISMNGEVIA 265

  Fly   268 CKGGCQVIADTGTSLIAAPLEEATSINQKIGGTPIIGGQYVVSCDLIPQLPVIKFVLGGKTFELE 332
            |.||||.|.||||||:..|.....:|...||......|:|.:.||.|..||.|.|.:|..|:.:.
Mouse   266 CDGGCQGIMDTGTSLLTGPRSSIVNIQNLIGAKASGDGEYFLKCDTINTLPDIVFTIGSVTYPVP 330

  Fly   333 GKDYILRVAQMGKTICLSGF-MGLDIPPPNGPLWILGDVFIGKYYTEFDMGNDRVGFADA 391
            ...||.:.....   |.|.| .|:| .|.:..:|:|||||:..|:|.||..|:|:|.|.|
Mouse   331 ASAYIRKDRSHN---CRSNFEEGMD-DPSDPEMWVLGDVFLRLYFTVFDRANNRIGLAPA 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cathD	NP_001334713.1	None
Pga5	NP_067428.2	A1_Propeptide	16..44	CDD:285240	6/27 (22%)
		pepsin_retropepsin_like	64..385	CDD:299705	136/328 (41%)
		Asp	74..386	CDD:278455	132/319 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.930