Protein Alignment cathD and Bace2

DIOPT Version :10

• Sequence 1: NP_652013.1
• Gene: cathD / 45268
• FlyBaseID: FBgn0029093
• Length: 392
• Species: Drosophila melanogaster
• Sequence 2: NP_062390.3
• Gene: Bace2 / 56175
• MGIID: 1860440
• Length: 514
• Species: Mus musculus
• Alignment Length: 378
• Identity: 90/378 - (23%)
• Similarity: 150/378 - (39%)
• Gaps: 101/378 - (26%)

  Fly    73 YYGPIAIGSPPQNFRVVFDTGSSNLWVPSKKCHLTNIACLMHNKYDASKSKTYTKNGTEFAIQYG 137
            ||..:.||:|||..:::.||||||..|.... |     ..:...:|:..|.||...|.:..::|.
Mouse    88 YYLEMLIGTPPQKVQILVDTGSSNFAVAGAP-H-----SYIDTYFDSESSSTYHSKGFDVTVKYT 146

  Fly   138 SGSLSGYLSTDTVSIAG-------LDIKDQTFAEALSEPGLVFVAAKFDGILGLGYNSISVDKVK 195
            .||.:|::..|.|:|..       ::|.....:|....||:     |::|||||.|.:::    |
Mouse   147 QGSWTGFVGEDLVTIPKGFNSSFLVNIATIFESENFFLPGI-----KWNGILGLAYAALA----K 202

  Fly   196 PP------FYAMYEQGLISAPVFSFY-----LNRDPASPEGGEIIFGGSDPNHYTGEFTYLPVTR 249
            |.      |.::..|..| ..:||..     |....:...||.::.||.:|:.|.|:..|.|:..
Mouse   203 PSSSLETFFDSLVAQAKI-PDIFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKE 266

  Fly   250 KAYWQIKMDAASIGDLQL---CK--GGCQVIADTGTSLIAAPLEEATSINQKIGGTPII------ 303
            :.|:||::....||...|   |:  ...:.|.|:||:|:..|.:...::.:.:..|.:|
Mouse   267 EWYYQIEILKLEIGGQNLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARTSLIPEFSDG 331

  Fly   304 ---GGQYVVSC-----------------------------DLIPQLPVIKFVLGGKTFELEGKDY 336
               |.|  ::|                             .::|||.:...:..|..:|
Mouse   332 FWTGAQ--LACWTNSETPWAYFPKISIYLRDENASRSFRITILPQLYIQPMMGAGFNYE------ 388

  Fly   337 ILRVAQMGKTICLSGFMGLDIPPPNGPLWILGDVFIGKYYTEFDMGNDRVGFA 389
            ..|......|..|                ::|...:..:|..||....|||||
Mouse   389 CYRFGISSSTNAL----------------VIGATVMEGFYVVFDRAQRRVGFA 425

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cathD	NP_652013.1	A1_Propeptide	29..56	CDD:462326
		pepsin_retropepsin_like	62..389	CDD:472175	88/376 (23%)
Bace2	NP_062390.3	beta_secretase_like	85..446	CDD:133140	90/378 (24%)