Protein Alignment cathD and PGC

DIOPT Version :9

• Sequence 1: NP_001334713.1
• Gene: cathD / 45268
• FlyBaseID: FBgn0029093
• Length: 392
• Species: Drosophila melanogaster
• Sequence 2: NP_002621.1
• Gene: PGC / 5225
• HGNCID: 8890
• Length: 388
• Species: Homo sapiens
• Alignment Length: 401
• Identity: 166/401 - (41%)
• Similarity: 238/401 - (59%)
• Gaps: 32/401 - (7%)

  Fly     4 VALLLVAFLAAAVAHPNSQEKPGLLRVPLHKFQSARRHFADVGTELQQLRI-------RYGGGDV 61
            |.|:.:..|.|||           ::|||.||:|.|....:.|...:.||.       :|..||:
Human     6 VVLVCLQLLEAAV-----------VKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDL 59

  Fly    62 P---EPLSNYMDAQYYGPIAIGSPPQNFRVVFDTGSSNLWVPSKKCHLTNIACLMHNKYDASKSK 123
            .   ||:: ||||.|:|.|:||:|||||.|:||||||||||||..|.  :.||..|::::.|:|.
Human    60 SVTYEPMA-YMDAAYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQ--SQACTSHSRFNPSESS 121

  Fly   124 TYTKNGTEFAIQYGSGSLSGYLSTDTVSIAGLDIKDQTFAEALSEPGLVFVAAKFDGILGLGYNS 188
            ||:.||..|::|||||||:|:...||:::..:.:.:|.|..:.:|||..||.|:||||:||.|.:
Human   122 TYSTNGQTFSLQYGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPA 186

  Fly   189 ISVDKVKPPFYAMYEQGLISAPVFSFYLNRDPASPEGGEIIFGGSDPNHYTGEFTYLPVTRKAYW 253
            :|||:.......|.::|.:::||||.||:....| .||.::|||.|.:.|||:..:.|||::.||
Human   187 LSVDEATTAMQGMVQEGALTSPVFSVYLSNQQGS-SGGAVVFGGVDSSLYTGQIYWAPVTQELYW 250

  Fly   254 QIKMDAASIGDLQ--LCKGGCQVIADTGTSLIAAPLEEATSINQKIGGTPIIGGQYVVSCDLIPQ 316
            ||.::...||...  .|..|||.|.||||||:..|.:..:::.|..|......||::|:|:.|..
Human   251 QIGIEEFLIGGQASGWCSEGCQAIVDTGTSLLTVPQQYMSALLQATGAQEDEYGQFLVNCNSIQN 315

  Fly   317 LPVIKFVLGGKTFELEGKDYILRVAQMGKTICLSGFMGLDIPPPNG-PLWILGDVFIGKYYTEFD 380
            ||.:.|::.|..|.|....|||    .....|..|.....:...|| |||||||||:..||:.:|
Human   316 LPSLTFIINGVEFPLPPSSYIL----SNNGYCTVGVEPTYLSSQNGQPLWILGDVFLRSYYSVYD 376

  Fly   381 MGNDRVGFADA 391
            :||:|||||.|
Human   377 LGNNRVGFATA 387

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cathD	NP_001334713.1	None
PGC	NP_002621.1	A1_Propeptide	18..46	CDD:285240	11/38 (29%)
		gastricsin	70..387	CDD:133144	142/323 (44%)
		Asp	72..387	CDD:278455	140/321 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.830