Protein Alignment cathD and bace2

DIOPT Version :9

• Sequence 1: NP_001334713.1
• Gene: cathD / 45268
• FlyBaseID: FBgn0029093
• Length: 392
• Species: Drosophila melanogaster
• Sequence 2: XP_009289748.1
• Gene: bace2 / 449818
• ZFINID: ZDB-GENE-041010-68
• Length: 503
• Species: Danio rerio
• Alignment Length: 420
• Identity: 109/420 - (25%)
• Similarity: 175/420 - (41%)
• Gaps: 77/420 - (18%)

  Fly    27 LLRVPLHKFQSARRHFADVGTELQQLRIRYGG-------GDVPEPLSNYMD----------AQYY 74
            :.::||:.|  |.:..|.|..:|:.|:.....       ...|..:.|::|          ..||
Zfish    19 VFKIPLNIF--AGKFNASVQLDLRPLQKNEAAAKSGLSLASDPAGIVNFLDMINNLKGDSGRGYY 81

  Fly    75 GPIAIGSPPQNFRVVFDTGSSNLWVPSKKCHLTNIACLMH----NKYDASKSKTYTKNGTEFAIQ 135
            ..:.||:|.|...::.||||||.          .:|...|    :.::.:.|.||.......|::
Zfish    82 MQMIIGTPGQTLNILVDTGSSNF----------AVAAAAHPYITHYFNRALSSTYQSTERAVAVK 136

  Fly   136 YGSGSLSGYLSTDTVSI-----AGLDIKDQTFAEALSEPGLVFVAAKFDGILGLGYNSIS--VDK 193
            |..|...|.|.||.::|     ..:.|   ..|..|:..|.......:.|||||.|..::  ...
Zfish   137 YTQGEWEGELGTDLITIPEGPSGAITI---NIAAILTSEGFFLPGINWQGILGLAYPLLARPDPS 198

  Fly   194 VKPPFYAMYEQGLISAPVFSFYL--NRDPAS----PEGGEIIFGGSDPNHYTGEFTYLPVTRKAY 252
            |:|.|.::..|..| ..|||..:  ...|||    |.||.:|.||.:|..:.|...|.||..:.|
Zfish   199 VEPFFNSVVRQTGI-PDVFSLQMCGAGVPASTTGDPAGGSLIMGGVEPTLHRGPIWYTPVLEEWY 262

  Fly   253 WQIKMDAASIGDLQL---CK--GGCQVIADTGTSLIAAPLEEATSINQKIGGTPII----GGQY- 307
            :|:::....:||..|   ||  ...:.|.|:||:|:..|....|::...|..|.:|    .|.:
Zfish   263 YQVEVLKLEVGDQNLNLDCKEYNSDKAIVDSGTTLLRLPANVFTAVVDTIMQTSLIDDFSAGFFD 327

  Fly   308 --VVSCDLIPQ-----LPVIKFVLGG----KTFELE--GKDYILRVAQMGKTICLSGFMGLDIPP 359
              .::|.:..:     .|.:...|.|    ::|.:.  .:.||..|..:..|:....| |:. |.
Zfish   328 GTKLACWMRGESPWRFFPKVSIYLRGTNTSQSFRITILPQLYIQPVTDIDGTLDCFRF-GIS-PS 390

  Fly   360 PNGPLWILGDVFIGKYYTEFDMGNDRVGFA 389
            .||  .::|...:..:|..||....|||||
Zfish   391 ANG--LVIGATVMEGFYVIFDRAQKRVGFA 418

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cathD	NP_001334713.1	None
bace2	XP_009289748.1	beta_secretase_like	77..439	CDD:133140	98/360 (27%)
		Asp	80..418	CDD:278455	96/355 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810