DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cathD and ren

DIOPT Version :9

Sequence 1:	NP_001334713.1	Gene:	cathD / 45268	FlyBaseID:	FBgn0029093	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	NP_998025.1	Gene:	ren / 405786	ZFINID:	ZDB-GENE-040630-3	Length:	395	Species:	Danio rerio

Alignment Length:	395	Identity:	172/395 - (43%)
Similarity:	238/395 - (60%)	Gaps:	18/395 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLVAFLAAAVAHPNSQEKPGLLRVPLHKFQSARRHFADVGTE----LQQLRIRY-----GGGDVP 62
            ||:..|:|.       ....|.||.|.|..|.|....::...    |.::..:|     ..|..|
Zfish     8 LLILSLSAI-------STKALWRVKLKKMPSIRETLKEMSVTPAQVLSEIMPKYQEPSPTNGTAP 65

  Fly    63 EPLSNYMDAQYYGPIAIGSPPQNFRVVFDTGSSNLWVPSKKCHLTNIACLMHNKYDASKSKTYTK 127
            .||.||:|.||:|.|:||||.|.|.|||||||:||||||..|.....||..||:||||||.|:..
Zfish    66 TPLINYLDTQYFGEISIGSPAQMFNVVFDTGSANLWVPSHSCSPLYTACFTHNRYDASKSLTHIF 130

  Fly   128 NGTEFAIQYGSGSLSGYLSTDTVSIAGLDIKDQTFAEALSEPGLVFVAAKFDGILGLGYNSISVD 192
            |||.|:|||.||::.|:||.|.|.:.|:.:. |.||||.:.|.:.|:.|||||:||:||.::::|
Zfish   131 NGTGFSIQYASGNVRGFLSEDVVVVGGIPVV-QVFAEATALPAIPFILAKFDGVLGMGYPNVAID 194

  Fly   193 KVKPPFYAMYEQGLISAPVFSFYLNRDPASPEGGEIIFGGSDPNHYTGEFTYLPVTRKAYWQIKM 257
            .:.|.|..:..|.::...|||.|.:|||....|||::.||:|||::||.|.|:....:..|::.|
Zfish   195 GITPVFDRIMSQHVLKENVFSVYYSRDPTHIPGGELVLGGTDPNYHTGPFHYINTKEQGKWEVIM 259

  Fly   258 DAASIG-DLQLCKGGCQVIADTGTSLIAAPLEEATSINQKIGGTPIIGGQYVVSCDLIPQLPVIK 321
            ...|:| |:..||.||..:.|||:|.|..|....:.:.:.||...:..|.|.|||:::..||.:.
Zfish   260 KGVSVGADILFCKDGCTAVIDTGSSYITGPASSISILMKTIGAVELAEGGYTVSCNVVRLLPTVA 324

  Fly   322 FVLGGKTFELEGKDYILRVAQMGKTICLSGFMGLDIPPPNGPLWILGDVFIGKYYTEFDMGNDRV 386
            |.|||:.:.|..:||||..::.|:.||...|..||:|||.||:||||..||.:||||||.||:|:
Zfish   325 FHLGGQEYSLTDEDYILWQSEFGEDICTVTFKALDVPPPTGPVWILGANFIARYYTEFDRGNNRI 389

  Fly   387 GFADA 391
            |||.|
Zfish   390 GFARA 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cathD	NP_001334713.1	None
ren	NP_998025.1	A1_Propeptide	23..>38	CDD:285240	6/14 (43%)
		renin_like	68..394	CDD:133154	155/326 (48%)
		Asp	75..394	CDD:278455	151/319 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X163
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	7.890