DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cathD and Ctse

DIOPT Version :9

Sequence 1:	NP_001334713.1	Gene:	cathD / 45268	FlyBaseID:	FBgn0029093	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	XP_006249810.1	Gene:	Ctse / 25424	RGDID:	2446	Length:	398	Species:	Rattus norvegicus

Alignment Length:	404	Identity:	183/404 - (45%)
Similarity:	245/404 - (60%)	Gaps:	29/404 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VALLLVAFLAAAVAHPNSQEKPGLL-RVPLHKFQSARR--------------HFADVGTELQQLR 53
            |.|||:..|..|.|.       |:| ||||.:.||.|:              |..|:....:...
  Rat     6 VLLLLLLLLDLAQAQ-------GVLHRVPLRRHQSLRKKLRAQGQLSDFWRSHNLDMIEFSESCN 63

  Fly    54 IRYGGGDVPEPLSNYMDAQYYGPIAIGSPPQNFRVVFDTGSSNLWVPSKKCHLTNIACLMHNKYD 118
            :..|   :.|||.||:|.:|:|.::||||.|||.|:||||||||||||..|  |:.||..|..:.
  Rat    64 VDKG---INEPLINYLDMEYFGTVSIGSPSQNFTVIFDTGSSNLWVPSVYC--TSPACKAHPVFH 123

  Fly   119 ASKSKTYTKNGTEFAIQYGSGSLSGYLSTDTVSIAGLDIKDQTFAEALSEPGLVFVAAKFDGILG 183
            .|:|.||.:.|..|:||||:|||:|.:..|.||:.||.::.|.|.|::.|||..||.|:||||||
  Rat   124 PSQSSTYMEVGNHFSIQYGTGSLTGIIGADQVSVEGLTVEGQQFGESVKEPGQTFVNAEFDGILG 188

  Fly   184 LGYNSISVDKVKPPFYAMYEQGLISAPVFSFYLNRDPASPEGGEIIFGGSDPNHYTGEFTYLPVT 248
            |||.|::|..|.|.|..|..|.|::.|:||.||:.||....|.|:.|||.||:|::|...::|||
  Rat   189 LGYPSLAVGGVTPVFDNMMAQNLVALPMFSVYLSSDPQGGSGSELTFGGYDPSHFSGSLNWIPVT 253

  Fly   249 RKAYWQIKMDAASIGD-LQLCKGGCQVIADTGTSLIAAPLEEATSINQKIGGTPIIGGQYVVSCD 312
            ::.||||.:|...:|| :..|..|||.|.|||||||..|.::...:.:.||.|| :.|:|.|.|.
  Rat   254 KQGYWQIALDGIQVGDTVMFCSEGCQAIVDTGTSLITGPPKKIKQLQEAIGATP-MDGEYAVDCA 317

  Fly   313 LIPQLPVIKFVLGGKTFELEGKDYILRVAQMGKTICLSGFMGLDIPPPNGPLWILGDVFIGKYYT 377
            .:..:|.:.|::.|.::.|....|||.....|...|.|||.||||.||.|||||||||||.|:|:
  Rat   318 TLNMMPNVTFLINGVSYTLSPTAYILPDLVDGMQFCGSGFQGLDIQPPAGPLWILGDVFIRKFYS 382

  Fly   378 EFDMGNDRVGFADA 391
            .||.||::||.|.|
  Rat   383 VFDRGNNQVGLAPA 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cathD	NP_001334713.1	None
Ctse	XP_006249810.1	A1_Propeptide	23..51	CDD:285240	8/27 (30%)
		Asp	79..396	CDD:278455	157/319 (49%)
		pepsin_retropepsin_like	80..395	CDD:299705	156/317 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100536
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X163
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.830