DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cathD and Ren

DIOPT Version :9

Sequence 1:	NP_001334713.1	Gene:	cathD / 45268	FlyBaseID:	FBgn0029093	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	NP_036774.4	Gene:	Ren / 24715	RGDID:	3554	Length:	402	Species:	Rattus norvegicus

Alignment Length:	396	Identity:	168/396 - (42%)
Similarity:	235/396 - (59%)	Gaps:	14/396 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLVAFLAAAVAHPNSQEKPGLLRVPLHKFQSARRHFADVGTELQQLRIRYGG-------GDVPEP 64
            ||:.:.:.:.:.|......|  |:.|.|..|.|....:.|.::.::...:|.       .:|..|
  Rat    11 LLLLWTSCSFSLPTDTASFG--RILLKKMPSVREILEERGVDMTRISAEWGEFIKKSSFTNVTSP 73

  Fly    65 --LSNYMDAQYYGPIAIGSPPQNFRVVFDTGSSNLWVPSKKCHLTNIACLMHNKYDASKSKTYTK 127
              |:||:|.||||.|.||:|.|.|:|:|||||:||||||.||.....||.:||.||:|:|.:|.:
  Rat    74 VVLTNYLDTQYYGEIGIGTPSQTFKVIFDTGSANLWVPSTKCGPLYTACEIHNLYDSSESSSYME 138

  Fly   128 NGTEFAIQYGSGSLSGYLSTDTVSIAGLDIKDQTFAEALSEPGLVFVAAKFDGILGLGYNSISVD 192
            |||||.|.||||.:.|:||.|.|::.|: |..|||.|....|.:.|:.|||||:||:|:.:.:||
  Rat   139 NGTEFTIHYGSGKVKGFLSQDVVTVGGI-IVTQTFGEVTELPLIPFMLAKFDGVLGMGFPAQAVD 202

  Fly   193 KVKPPFYAMYEQGLISAPVFSFYLNRDPASPEGGEIIFGGSDPNHYTGEFTYLPVTRKAYWQIKM 257
            .|.|.|..:..|.::...|||.|.:|: :...|||::.|||||.||.|.|.|:.:::...|||.|
  Rat   203 GVIPVFDHILSQRVLKEEVFSVYYSRE-SHLLGGEVVLGGSDPQHYQGNFHYVSISKAGSWQITM 266

  Fly   258 DAASIGDLQ-LCKGGCQVIADTGTSLIAAPLEEATSINQKIGGTPIIGGQYVVSCDLIPQLPVIK 321
            ...|:|... ||:.||..:.|||||.|:.|......|.|.:|........|||:|..:|.||.|.
  Rat   267 KGVSVGPATLLCEEGCMAVVDTGTSYISGPTSSLQLIMQALGVKEKRANNYVVNCSQVPTLPDIS 331

  Fly   322 FVLGGKTFELEGKDYILRVAQMGKTICLSGFMGLDIPPPNGPLWILGDVFIGKYYTEFDMGNDRV 386
            |.|||:|:.|...||:.:.......:|:....|||||||.||:|:||..||.|:|||||..|:|:
  Rat   332 FYLGGRTYTLSNMDYVQKNPFRNDDLCILALQGLDIPPPTGPVWVLGATFIRKFYTEFDRHNNRI 396

  Fly   387 GFADAK 392
            |||.|:
  Rat   397 GFALAR 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cathD	NP_001334713.1	None
Ren	NP_036774.4	A1_Propeptide	31..64	CDD:400357	7/32 (22%)
Ren	NP_036774.4	renin_like	76..401	CDD:133154	154/326 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X163
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.890