DRSC/TRiP Functional Genomics Resources

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Protein Alignment cathD and Bace1

DIOPT Version :10

Sequence 1:NP_652013.1 Gene:cathD / 45268 FlyBaseID:FBgn0029093 Length:392 Species:Drosophila melanogaster
Sequence 2:NP_035922.4 Gene:Bace1 / 23821 MGIID:1346542 Length:501 Species:Mus musculus


Alignment Length:409 Identity:109/409 - (26%)
Similarity:168/409 - (41%) Gaps:86/409 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 EKPGLLRVPLHKFQSARRHFADVGTELQQLRIRYGGGDVPEPLSNYMDAQYYGPIAIGSPPQNFR 87
            |:||           .|..|.::   :..||.:.|.|             ||..:.:|||||...
Mouse    52 EEPG-----------RRGSFVEM---VDNLRGKSGQG-------------YYVEMTVGSPPQTLN 89

  Fly    88 VVFDTGSSNLWVPSKKCHLTNIACLMHNKYDASKSKTYTKNGTEFAIQYGSGSLSGYLSTDTVSI 152
            ::.||||||..|.:.. |     ..:|..|....|.||........:.|..|...|.|.||.|||
Mouse    90 ILVDTGSSNFAVGAAP-H-----PFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSI 148

  Fly   153 A-GLDIKDQTFAEALSEPGLVFV-AAKFDGILGLGYNSIS--VDKVKPPFYAMYEQGLISAPVFS 213
            . |.::..:....|::|....|: .:.::|||||.|..|:  .|.::|.|.::.:|..| ..:||
Mouse   149 PHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHI-PNIFS 212

  Fly   214 -------FYLNRDPA-SPEGGEIIFGGSDPNHYTGEFTYLPVTRKAYWQIKMDAASIG--DLQL- 267
                   |.||:..| :..||.:|.||.|.:.|||...|.|:.|:.|:::.:....|.  ||:: 
Mouse   213 LQLCGAGFPLNQTEALASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMD 277

  Fly   268 CK--GGCQVIADTGTSLIAAPLE---------EATSINQKIGGTPIIGGQYVV-SCDLIPQ--LP 318
            ||  ...:.|.|:||:.:..|.:         :|.|..:|......:|.|.|. .....|.  .|
Mouse   278 CKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFP 342

  Fly   319 VIKFVLGG----KTFELE--GKDYILRVAQMG-------KTICLSGFMGLDIPPPNGPLWILGDV 370
            ||...|.|    ::|.:.  .:.|:..|..:.       |........|.          ::|.|
Mouse   343 VISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAVSQSSTGT----------VMGAV 397

  Fly   371 FIGKYYTEFDMGNDRVGFA 389
            .:..:|..||....|:|||
Mouse   398 IMEGFYVVFDRARKRIGFA 416

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cathDNP_652013.1 A1_Propeptide 29..56 CDD:462326 4/26 (15%)
pepsin_retropepsin_like 62..389 CDD:472175 98/368 (27%)
Bace1NP_035922.4 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 39..58 3/16 (19%)
beta_secretase_like 72..437 CDD:133140 102/375 (27%)
Interaction with RTN3. /evidence=ECO:0000250 479..501
DXXLL. /evidence=ECO:0000250|UniProtKB:P56817 496..500
Blue background indicates that the domain is not in the aligned region.

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