Protein Alignment cathD and Ren2

DIOPT Version :10

• Sequence 1: NP_652013.1
• Gene: cathD / 45268
• FlyBaseID: FBgn0029093
• Length: 392
• Species: Drosophila melanogaster
• Sequence 2: NP_112470.2
• Gene: Ren2 / 19702
• MGIID: 97899
• Length: 424
• Species: Mus musculus
• Alignment Length: 377
• Identity: 162/377 - (42%)
• Similarity: 230/377 - (61%)
• Gaps: 18/377 - (4%)

  Fly    29 RVPLHKFQSARRHFADVGTELQQLRIRYGGGDV------------PEPLSNYMDAQYYGPIAIGS 81
            |:||.|..|.|....:.|.::.:|...:   ||            |..|:||:::||||.|.||:
Mouse    53 RIPLKKMPSVREILEERGVDMTRLSAEW---DVFTKRSSLTDLISPVVLTNYLNSQYYGEIGIGT 114

  Fly    82 PPQNFRVVFDTGSSNLWVPSKKCHLTNIACLMHNKYDASKSKTYTKNGTEFAIQYGSGSLSGYLS 146
            |||.|:|:|||||:||||||.||....:||.:|:.|::|.|.:|.:||.:|.|.||||.:.|:||
Mouse   115 PPQTFKVIFDTGSANLWVPSTKCSRLYLACGIHSLYESSDSSSYMENGDDFTIHYGSGRVKGFLS 179

  Fly   147 TDTVSIAGLDIKDQTFAEALSEPGLVFVAAKFDGILGLGYNSISVDKVKPPFYAMYEQGLISAPV 211
            .|:|::.|:.: .|||.|....|.:.|:.|:|||:||:|:.:.:|..|.|.|..:..||::...|
Mouse   180 QDSVTVGGITV-TQTFGEVTELPLIPFMLAQFDGVLGMGFPAQAVGGVTPVFDHILSQGVLKEKV 243

  Fly   212 FSFYLNRDPASPEGGEIIFGGSDPNHYTGEFTYLPVTRKAYWQIKMDAASIG-DLQLCKGGCQVI 275
            ||.|.||.| ...|||::.|||||.||.|:|.|:.:::...|||.|...|:| ...||:.||:|:
Mouse   244 FSVYYNRGP-HLLGGEVVLGGSDPEHYQGDFHYVSLSKTDSWQITMKGVSVGSSTLLCEEGCEVV 307

  Fly   276 ADTGTSLIAAPLEEATSINQKIGGTPIIGGQYVVSCDLIPQLPVIKFVLGGKTFELEGKDYILRV 340
            .|||:|.|:||......|.|.:|.......:|||||..:|.||.|.|.|||:.:.|...||:|:.
Mouse   308 VDTGSSFISAPTSSLKLIMQALGAKEKRLHEYVVSCSQVPTLPDISFNLGGRAYTLSSTDYVLQY 372

  Fly   341 AQMGKTICLSGFMGLDIPPPNGPLWILGDVFIGKYYTEFDMGNDRVGFADAK 392
            ......:|......:|||||.||:|:||..||.|:|||||..|:|:|||.|:
Mouse   373 PNRRDKLCTVALHAMDIPPPTGPVWVLGATFIRKFYTEFDRHNNRIGFALAR 424

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cathD	NP_652013.1	A1_Propeptide	29..56	CDD:462326	8/26 (31%)
		pepsin_retropepsin_like	62..389	CDD:472175	149/327 (46%)
Ren2	NP_112470.2	A1_Propeptide	53..>71	CDD:462326	6/17 (35%)
		renin_like	98..423	CDD:133154	150/326 (46%)