Protein Alignment cathD and asp-18

DIOPT Version :10

• Sequence 1: NP_652013.1
• Gene: cathD / 45268
• FlyBaseID: FBgn0029093
• Length: 392
• Species: Drosophila melanogaster
• Sequence 2: NP_507653.2
• Gene: asp-18 / 191310
• WormBaseID: WBGene00013973
• Length: 392
• Species: Caenorhabditis elegans
• Alignment Length: 406
• Identity: 139/406 - (34%)
• Similarity: 198/406 - (48%)
• Gaps: 45/406 - (11%)

  Fly     6 LLLVAFLAAAVAHPNSQEKPGLLRVPLHKFQSAR-------RHFADVGTELQQLRIRYGGGDVPE 63
            ||||...:|||           .:||.....|.|       ::.:.:.:.||||...      .:
 Worm     5 LLLVTTCSAAV-----------FQVPTTTSGSFRAKLIREGKYSSFLASRLQQLNTG------SQ 52

  Fly    64 PLSNYMDAQYYGPIAIGSPPQNFRVVFDTGSSNLWVPSKKCHLTNIAC------LMHNKYDASKS 122
            ||..:.|....|.|.||||||:..|..||.|:||||....|  |::.|      ::.:|::.:||
 Worm    53 PLLGFSDDPCIGNITIGSPPQSAFVFMDTTSANLWVMGSAC--TSVNCNDPLLGIIKHKFNTTKS 115

  Fly   123 KTYTKNGTEFAIQYGSGSLSGYLSTDTVSIAGLDIKDQTFAEALSEPGLV---FVAAKFDGILGL 184
            .::.|:..:|.||||||..||||.||||.|.||.|:.|.|..|    .:|   |.....|||.||
 Worm   116 TSFVKSNRKFNIQYGSGECSGYLGTDTVEIGGLKIQKQEFGVA----NIVDYDFGTRPIDGIFGL 176

  Fly   185 GYNSISVDKVKPPFYAMYEQGLISAPVFS-FYLNRDP--ASPEGGEIIFGGSDPNHYTGEFTYLP 246
            .:.::|||:|.||...:..|..:.||:|: |:..|||  ..|..|.|.:||.|..:.....:|:|
 Worm   177 AWPALSVDQVTPPMQNLVSQNQLDAPIFTIFFDKRDPDYYYPSNGLITYGGLDTKNCNANISYVP 241

  Fly   247 VTRKAYWQIKMDAASIGDLQLCKGGCQVIADTGTSLIAAPLEEATSINQKIGGT-PIIGGQYVVS 310
            |:.|.|||.|:|...:|.........|.|.|||:|....|......|..:...| .:....|.|.
 Worm   242 VSSKTYWQFKVDGFQVGTYNRTVNRDQAIMDTGSSWFGLPYSVIAGIATQTNATWDLYASVYTVP 306

  Fly   311 CDLIPQLPVIKFVLGGKTFELEGKDYILRVAQMGKTICLSGFMGLDIPPPNGPLWILGDVFIGKY 375
            |..:..||.:.|.:|.:.|.:...:|:..|. :....|.....|:| ....||...||::||.:|
 Worm   307 CSTMNSLPDLVFTIGAEKFPISAPEYVEDVG-LDDGTCALAMYGID-ASGFGPSVTLGNIFIRRY 369

  Fly   376 YTEFDMGNDRVGFADA 391
            .:.||:||.|:|||||
 Worm   370 CSVFDVGNARIGFADA 385

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cathD	NP_652013.1	A1_Propeptide	29..56	CDD:462326	8/33 (24%)
		pepsin_retropepsin_like	62..389	CDD:472175	120/339 (35%)
asp-18	NP_507653.2	pepsin_like	63..383	CDD:133138	117/327 (36%)