Protein Alignment cathD and asp-5

DIOPT Version :10

• Sequence 1: NP_652013.1
• Gene: cathD / 45268
• FlyBaseID: FBgn0029093
• Length: 392
• Species: Drosophila melanogaster
• Sequence 2: NP_505135.1
• Gene: asp-5 / 179211
• WormBaseID: WBGene00000218
• Length: 393
• Species: Caenorhabditis elegans
• Alignment Length: 417
• Identity: 132/417 - (31%)
• Similarity: 197/417 - (47%)
• Gaps: 54/417 - (12%)

  Fly     1 MQKVALLLVAFL----AAAVAHPNSQEKPGLLRVPLHKFQSARRHFADVGTELQ-QLRIRYGG-- 58
            |:...:.|||.|    |..|.|.       |:.....|.|..||  .:.|..:| :..:|...
 Worm     1 MKTTFVALVALLGLCSATVVQHK-------LIYRESIKMQMMRR--GEWGAYVQHKAALRDADPA 56

  Fly    59 --GDVPEPLSNYMDAQYYGPIAIGSPPQNFRVVFDTGSSNLWVPSKKCHLTNIACLMHNKYDASK 121
              .:.|:.::::.|.:|.|.|.||:|||.|.||.||||||||||...|   :.:|....:|.::|
 Worm    57 VYANAPQNVNDFGDFEYLGNITIGTPPQPFLVVLDTGSSNLWVPGPSC---DGSCKGKREYQSTK 118

  Fly   122 SKTYTKNGTEFAIQYGSGSLSGYLSTDTVSIAG-----LDIKDQTFAEALSEPGLVFVAAKF--- 178
            |.|:..||..:.||||||:..|||..|||:...     |.:...||..|      ..:::.|
 Worm   119 SSTFKANGKPWQIQYGSGNAKGYLGEDTVAFGAVTEKQLPVPSTTFGIA------THISSDFKND 177

  Fly   179 --DGILGLGYNSISVDKVKPPFYAMYEQGLISAPVFSFYLNRDPASPE--GGEIIFGGSDPNHYT 239
              :|||||.:.|::||.|.||......|||:..|:|:.:|....::.:  ||...:|..|..:..
 Worm   178 AAEGILGLAFTSLAVDHVVPPLINAINQGLLDQPLFTVWLEHKGSANDVGGGVFTYGAVDTTNCG 242

  Fly   240 GEFTYLPVTRKAYWQIKMDAASIGDLQLCKGGCQVIADTGTSLIAAPLEEATSINQKIGGT-PII 303
            ....|.|::...|:|...|:..:|.....| ..|||:|||||.:..|......:...:|.| ...
 Worm   243 PVIAYQPLSSATYYQFVADSFKLGSYSNSK-KYQVISDTGTSFLGGPKAVVAGLASALGATYHSN 306

  Fly   304 GGQYVVSCDLIPQLPVIKFVLGGKTFELEGKDYILRVAQMGKTICLSGF----MGLDIPPPNGPL 364
            ...|.|.|  ...:..:...:|||.:.:...:||:.|. ||.|...:.|    .|.      ||.
 Worm   307 DDSYYVPC--ATNIGTLDITIGGKVYSINPVNYIVDVG-MGDTCVFAAFAFNNFGF------GPA 362

  Fly   365 WILGDVFIGKYYTEFDMGNDRVGFADA 391
            |||||.||.::...:|:|..|:|||::
 Worm   363 WILGDPFIRQFCNIYDIGGQRMGFANS 389

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cathD	NP_652013.1	A1_Propeptide	29..56	CDD:462326	6/27 (22%)
		pepsin_retropepsin_like	62..389	CDD:472175	114/343 (33%)
asp-5	NP_505135.1	pepsin_retropepsin_like	72..387	CDD:472175	112/333 (34%)