Protein Alignment cathD and asp-12

DIOPT Version :10

• Sequence 1: NP_652013.1
• Gene: cathD / 45268
• FlyBaseID: FBgn0029093
• Length: 392
• Species: Drosophila melanogaster
• Sequence 2: NP_505134.1
• Gene: asp-12 / 179210
• WormBaseID: WBGene00017678
• Length: 395
• Species: Caenorhabditis elegans
• Alignment Length: 421
• Identity: 136/421 - (32%)
• Similarity: 194/421 - (46%)
• Gaps: 66/421 - (15%)

  Fly     1 MQKVALLLVAFL----AAAVAHP-NSQEKPGLLRVPLHKFQSARRHFADVGTELQ-QLRIRYGG- 58
            |:...|..||.|    |..|.|. ..:|.|        |.|..||  .:.|..:| :..:|...
 Worm     1 MKTTLLAFVAILGMCSATVVQHKLIYRESP--------KMQMMRR--GEWGAYVQHKAALRDANP 55

  Fly    59 ---GDVPEPLSNYMDAQYYGPIAIGSPPQNFRVVFDTGSSNLWVPSKKCHLTNIACLMHNKYDAS 120
               ...|:.::::.|.:|.|.|.||:|||.|.||.||||:|||||...|..|   |...:::|:|
 Worm    56 AVFASAPQNVNDFGDVEYLGNITIGTPPQQFIVVLDTGSANLWVPGSNCDGT---CKGKSEFDSS 117

  Fly   121 KSKTYTKNGTEFAIQYGSGSLSGYLSTDTVSIAGLDIKDQTFAEALSEPGLVF-----VAAKF-- 178
            ||.|:.|||..:.|||.|||..|.:..|||:..|..      .:.|..|...|     :::.|
 Worm   118 KSTTFKKNGQSWQIQYESGSAKGIMGVDTVAFGGAS------EQQLLVPSTTFGIASHISSNFKN 176

  Fly   179 ---DGILGLGYNSISVDKVKPPFYAMYEQGLISAPVFSFYLNRDPASPE--GGEIIFGGSDPNHY 238
               :|||||.:.|::||.|.||......:.::..|:|:.:|.....:..  ||...:|..|..:.
 Worm   177 DAAEGILGLAFTSLAVDGVTPPLINAINKKILDQPLFTVFLEHKGTAKNVGGGVFTYGAVDTTNC 241

  Fly   239 TGEFTYLPVTRKAYWQIKMDAASIGDLQLCKGGCQVIADTGTSLIAAPLEEATSINQKIGGTPII 303
            .....|.|::...|:|...|...:|.....|.. |||:|||:|||..|   :..||   |....:
 Worm   242 GPVIAYQPLSSATYYQFVADGFKLGSYSNNKKS-QVISDTGSSLIGGP---SAVIN---GFAQAL 299

  Fly   304 GGQYVVSCDLIPQLP------VIKFVLGGKTFELEGKDYILRVAQMGKTICLSGFM----GLDIP 358
            |.:| .|.|....||      .:...:||..:.:|..:|||.|. ||.|...:.|.    |.
 Worm   300 GAKY-HSDDDAYYLPCSTSKGTLDITIGGNVYSIEPVNYILDVG-MGDTCVFAAFSFDFGGF--- 359

  Fly   359 PPNGPLWILGDVFIGKYYTEFDMGNDRVGFA 389
               ||.||.||.||.:|...:|:|..|:|||
 Worm   360 ---GPSWIFGDPFIRQYCNIYDIGQQRIGFA 387

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cathD	NP_652013.1	A1_Propeptide	29..56	CDD:462326	6/27 (22%)
		pepsin_retropepsin_like	62..389	CDD:472175	117/348 (34%)
asp-12	NP_505134.1	pepsin_retropepsin_like	72..388	CDD:472175	117/340 (34%)