DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cathD and asp-8

DIOPT Version :9

Sequence 1:	NP_001334713.1	Gene:	cathD / 45268	FlyBaseID:	FBgn0029093	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	NP_503825.2	Gene:	asp-8 / 178750	WormBaseID:	WBGene00019105	Length:	386	Species:	Caenorhabditis elegans

Alignment Length:	403	Identity:	114/403 - (28%)
Similarity:	178/403 - (44%)	Gaps:	41/403 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VALLLVAFLAAAVAHPNSQEKPGLLRVPLHKFQSARRHFADVGTELQQLRIRYGGGDVPEPLSNY 68
            ::||.:..|.:|.....|.||.|.||..|  .:..|     .|.||.::: :...|:|  ...::
Worm     6 ISLLGLVALCSAGQFSISVEKSGSLREQL--IREGR-----YGQELARIQ-QLSTGNV--SFFDH 60

  Fly    69 MDAQYYGPIAIGSPPQNFRVVFDTGSSNLWVPSKKCHLTNIACLMH-------NKYDASKSKTYT 126
            .|..|...:.||:|.|:|:|.|||.||||||...:|...|  |  |       .:|:.:.|.|:.
Worm    61 FDEYYTAGVRIGTPAQHFQVAFDTTSSNLWVFGVECRSQN--C--HGGRGRRDREYNRTASSTFV 121

  Fly   127 KNGTEFAIQYGSGSLSGYLSTDTVSIAGLDIKDQTFAEALSEPGLVFVAAK-----FDGILGLGY 186
            ...:.|.:.|..|.:||.:..||...||..|:.|.|       |:...|.:     |||:||||:
Worm   122 AGTSSFNLPYDGGHVSGNVGKDTAQFAGFTIQSQDF-------GIGTAATRLFGETFDGVLGLGW 179

  Fly   187 NSISVDKVKPPFYAMYEQGLISAPVFSFYLNRDPA--SPEGGEIIFGGSDPNHYTGEFTYLPVTR 249
            .:.:::........:..|  :...:|:.|..:...  ...||:|:||..|..|...:..|:|:..
Worm   180 PATALNGTSTTMQNLLPQ--LDQKLFTTYFTKSNMHNGTAGGDIMFGAIDTTHCQSQVNYVPLAY 242

  Fly   250 KAYWQIKMDAASIGDLQLCKGGCQVIADTGTSLIAAPLEEATSINQKIGGTPIIGGQ-YVVSCDL 313
            .::|...:|..|||.....:.. ..|.||.:.....|......|.:..|.|.....| |.:.|..
Worm   243 NSFWSYSVDGFSIGTYSRTQTE-TTIPDTSSGWTGVPNVVLAGIVKATGATYDWNHQAYTLPCSS 306

  Fly   314 IPQLPVIKFVLGGKTFELEGKDYILRVAQMGKTICLSGFMGLDIPPPNGPLWILGDVFIGKYYTE 378
            ...||.:.|.:||.::.:...:|::.: .:....|.....| .....:||.|||||.|:..|...
Worm   307 TATLPDMVFTIGGNSYNVRAVEYVVNL-NLPNGQCALSLFG-TAASQSGPAWILGDNFLRSYCHV 369

  Fly   379 FDMGNDRVGFADA 391
            ||.||.|:|.|.|
Worm   370 FDFGNSRIGLAKA 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cathD	NP_001334713.1	None
asp-8	NP_503825.2	pepsin_like	65..381	CDD:133138	94/331 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D270366at33208
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.830