DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cathD and Ctsd

DIOPT Version :9

Sequence 1:	NP_001334713.1	Gene:	cathD / 45268	FlyBaseID:	FBgn0029093	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	NP_599161.2	Gene:	Ctsd / 171293	RGDID:	621511	Length:	407	Species:	Rattus norvegicus

Alignment Length:	407	Identity:	220/407 - (54%)
Similarity:	280/407 - (68%)	Gaps:	27/407 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VALLLVAFLAAAVAHPNSQEKPGLLRVPLHKFQSARRHFADVGTELQQLRI-----RYGGGDVP- 62
            |.||::..|||:        ...|:|:||.||.|.||...:||..::.|.:     :|.....|
  Rat     6 VLLLILGLLAAS--------SSALIRIPLRKFTSIRRTMTEVGGSVEDLILKGPITKYSMQSSPR 62

  Fly    63 --EPLS----NYMDAQYYGPIAIGSPPQNFRVVFDTGSSNLWVPSKKCHLTNIACLMHNKYDASK 121
              ||:|    ||:||||||.|.||:|||.|.||||||||||||||..|.|.:|||.:|:||::.|
  Rat    63 TKEPVSELLKNYLDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWVHHKYNSDK 127

  Fly   122 SKTYTKNGTEFAIQYGSGSLSGYLSTDTVSI------AGLDIKDQTFAEALSEPGLVFVAAKFDG 180
            |.||.||||.|.|.|||||||||||.||||:      .|:.::.|.|.||..:||:||:||||||
  Rat   128 SSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCKSDLGGIKVEKQIFGEATKQPGVVFIAAKFDG 192

  Fly   181 ILGLGYNSISVDKVKPPFYAMYEQGLISAPVFSFYLNRDPASPEGGEIIFGGSDPNHYTGEFTYL 245
            |||:||..|||:.|.|.|..:.:|.|:...:|||||||||....|||::.||:|..:|.||.:||
  Rat   193 ILGMGYPFISVNNVLPVFDNLMKQKLVEKNIFSFYLNRDPTGQPGGELMLGGTDSRYYHGELSYL 257

  Fly   246 PVTRKAYWQIKMDAASIG-DLQLCKGGCQVIADTGTSLIAAPLEEATSINQKIGGTPIIGGQYVV 309
            .||||||||:.||...:| :|.||||||:.|.||||||:..|::|...:.:.||..|:|.|:|::
  Rat   258 NVTRKAYWQVHMDQLEVGSELTLCKGGCEAIVDTGTSLLVGPVDEVKELQKAIGAVPLIQGEYMI 322

  Fly   310 SCDLIPQLPVIKFVLGGKTFELEGKDYILRVAQMGKTICLSGFMGLDIPPPNGPLWILGDVFIGK 374
            .|:.:..||:|.|.|||:.:||..:.|||:|:|.|||||||||||:|||||:||||||||||||.
  Rat   323 PCEKVSSLPIITFKLGGQNYELHPEKYILKVSQAGKTICLSGFMGMDIPPPSGPLWILGDVFIGC 387

  Fly   375 YYTEFDMGNDRVGFADA 391
            |||.||...:|||||.|
  Rat   388 YYTVFDREYNRVGFAKA 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cathD	NP_001334713.1	None
Ctsd	NP_599161.2	A1_Propeptide	21..46	CDD:285240	11/24 (46%)
		Cathepsin_D2	73..403	CDD:133157	195/329 (59%)
		Asp	78..404	CDD:278455	192/325 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340698
Domainoid	1	1.000	407	1.000	Domainoid score	I686
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55616
Inparanoid	1	1.050	434	1.000	Inparanoid score	I1645
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	1	1.000	-	-		otm44891
orthoMCL	1	0.900	-	-		OOG6_100536
Panther	1	1.100	-	-	LDO	PTHR47966
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X163
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810