DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cathD and CTSE

DIOPT Version :9

Sequence 1:	NP_001334713.1	Gene:	cathD / 45268	FlyBaseID:	FBgn0029093	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	XP_011507546.1	Gene:	CTSE / 1510	HGNCID:	2530	Length:	401	Species:	Homo sapiens

Alignment Length:	416	Identity:	178/416 - (42%)
Similarity:	240/416 - (57%)	Gaps:	42/416 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQKVALLLVAFLAAAVAHPNSQEKPGLLRVPLHKFQSARR--------------HFADV-----G 46
            |:.:.|||:..|....|      :..|.||||.:..|.::              |..|:     .
Human     1 MKTLLLLLLVLLELGEA------QGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTES 59

  Fly    47 TELQQLRIRYGGGDVPEPLSNYMDAQYYGPIAIGSPPQNFRVVFDTGSSNLWVPSKKCHLTNIAC 111
            ..:.|        ...|||.||:|.:|:|.|:||||||||.|:||||||||||||..|  |:.||
Human    60 CSMDQ--------SAKEPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPAC 114

  Fly   112 LMHNKYDASKSKTYTKNGTEFAIQYGSGSLSGYLSTDTVS-----IAGLDIKDQTFAEALSEPGL 171
            ..|:::..|:|.||::.|..|:||||:|||||.:..|.||     :.||.:..|.|.|:::|||.
Human   115 KTHSRFQPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSAFSYQVEGLTVVGQQFGESVTEPGQ 179

  Fly   172 VFVAAKFDGILGLGYNSISVDKVKPPFYAMYEQGLISAPVFSFYLNRDPASPEGGEIIFGGSDPN 236
            .||.|:|||||||||.|::|..|.|.|..|..|.|:..|:||.|::.:|....|.|:||||.|.:
Human   180 TFVDAEFDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHS 244

  Fly   237 HYTGEFTYLPVTRKAYWQIKMDAASI-GDLQLCKGGCQVIADTGTSLIAAPLEEATSINQKIGGT 300
            |::|...::|||::|||||.:|...: |.:..|..|||.|.|||||||..|.::...:...||..
Human   245 HFSGSLNWVPVTKQAYWQIALDNIQVGGTVMFCSEGCQAIVDTGTSLITGPSDKIKQLQNAIGAA 309

  Fly   301 PIIGGQYVVSCDLIPQLPVIKFVLGGKTFELEGKDYILRVAQMGKTICLSGFMGLDIPPPNGPLW 365
            | :.|:|.|.|..:..:|.:.|.:.|..:.|....|.|.....|...|.|||.||||.||.||||
Human   310 P-VDGEYAVECANLNVMPDVTFTINGVPYTLSPTAYTLLDFVDGMQFCSSGFQGLDIHPPAGPLW 373

  Fly   366 ILGDVFIGKYYTEFDMGNDRVGFADA 391
            |||||||.::|:.||.||:|||.|.|
Human   374 ILGDVFIRQFYSVFDRGNNRVGLAPA 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cathD	NP_001334713.1	None
CTSE	XP_011507546.1	A1_Propeptide	21..49	CDD:285240	6/27 (22%)
		Asp	77..399	CDD:278455	156/324 (48%)
		Cathespin_E	78..398	CDD:133153	155/322 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S917
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100536
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X163
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.780