Protein Alignment cathD and CTSD

DIOPT Version :10

• Sequence 1: NP_652013.1
• Gene: cathD / 45268
• FlyBaseID: FBgn0029093
• Length: 392
• Species: Drosophila melanogaster
• Sequence 2: NP_001900.1
• Gene: CTSD / 1509
• HGNCID: 2529
• Length: 412
• Species: Homo sapiens
• Alignment Length: 417
• Identity: 218/417 - (52%)
• Similarity: 279/417 - (66%)
• Gaps: 34/417 - (8%)

  Fly     1 MQKVALLLVAF-LAAAVAHPNSQEKPGLLRVPLHKFQSARRHFADVGTELQQLRIRYG------- 57
            ||..:||.:|. |.||.|       ..|:|:|||||.|.||..::||..::.| |..|
Human     1 MQPSSLLPLALCLLAAPA-------SALVRIPLHKFTSIRRTMSEVGGSVEDL-IAKGPVSKYSQ 57

  Fly    58 ------GGDVPEPLSNYMDAQYYGPIAIGSPPQNFRVVFDTGSSNLWVPSKKCHLTNIACLMHNK 116
                  .|.:||.|.|||||||||.|.||:|||.|.||||||||||||||..|.|.:|||.:|:|
Human    58 AVPAVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHK 122

  Fly   117 YDASKSKTYTKNGTEFAIQYGSGSLSGYLSTDTVSI-----------AGLDIKDQTFAEALSEPG 170
            |::.||.||.||||.|.|.|||||||||||.||||:           .|:.::.|.|.||..:||
Human   123 YNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPG 187

  Fly   171 LVFVAAKFDGILGLGYNSISVDKVKPPFYAMYEQGLISAPVFSFYLNRDPASPEGGEIIFGGSDP 235
            :.|:|||||||||:.|..|||:.|.|.|..:.:|.|:...:|||||:|||.:..|||::.||:|.
Human   188 ITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDS 252

  Fly   236 NHYTGEFTYLPVTRKAYWQIKMDAASIGD-LQLCKGGCQVIADTGTSLIAAPLEEATSINQKIGG 299
            .:|.|..:||.||||||||:.:|...:.. |.|||.||:.|.||||||:..|::|...:.:.||.
Human   253 KYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGA 317

  Fly   300 TPIIGGQYVVSCDLIPQLPVIKFVLGGKTFELEGKDYILRVAQMGKTICLSGFMGLDIPPPNGPL 364
            .|:|.|:|::.|:.:..||.|...||||.::|..:||.|:|:|.|||:|||||||:|||||:|||
Human   318 VPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSGFMGMDIPPPSGPL 382

  Fly   365 WILGDVFIGKYYTEFDMGNDRVGFADA 391
            |||||||||:|||.||..|:|||||:|
Human   383 WILGDVFIGRYYTVFDRDNNRVGFAEA 409

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cathD	NP_652013.1	A1_Propeptide	29..56	CDD:462326	13/26 (50%)
		pepsin_retropepsin_like	62..389	CDD:472175	190/338 (56%)
CTSD	NP_001900.1	A1_Propeptide	23..49	CDD:462326	13/26 (50%)
		Cathepsin_D2	73..408	CDD:133157	188/334 (56%)