Protein Alignment cathD and Pgc

DIOPT Version :10

• Sequence 1: NP_652013.1
• Gene: cathD / 45268
• FlyBaseID: FBgn0029093
• Length: 392
• Species: Drosophila melanogaster
• Sequence 2: NP_080249.2
• Gene: Pgc / 109820
• MGIID: 98909
• Length: 392
• Species: Mus musculus
• Alignment Length: 403
• Identity: 172/403 - (42%)
• Similarity: 226/403 - (56%)
• Gaps: 36/403 - (8%)

  Fly     4 VALLLVAFLAAAVAHPNSQEKPGLLRVPLHKFQSARRHFADVGTELQQLR-IRYGGGD------- 60
            ||||.:..|.||           |:||||.|.:|.|....:.|.....|: .:|..|.
Mouse     6 VALLCLPLLEAA-----------LIRVPLKKMKSIRETMKEQGVLKDFLKNHKYDPGQKYHFGKF 59

  Fly    61 -----VPEPLSNYMDAQYYGPIAIGSPPQNFRVVFDTGSSNLWVPSKKCHLTNIACLMHNKYDAS 120
                 :.||:: ||||.|||.|:||:|||||.|:||||||||||.|..|.  :.||..|.:|:.|
Mouse    60 GDYSVLYEPMA-YMDASYYGEISIGTPPQNFLVLFDTGSSNLWVSSVYCQ--SEACTTHTRYNPS 121

  Fly   121 KSKTYTKNGTEFAIQYGSGSLSGYLSTDTVSIAGLDIKDQTFAEALSEPGLVFVAAKFDGILGLG 185
            ||.||...|..|::|||:|||:|:...||:.:..:.:.:|.|..:.:|||..||.|:||||:||.
Mouse   122 KSSTYYTQGQTFSLQYGTGSLTGFFGYDTLRVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLA 186

  Fly   186 YNSISVDKVKPPFYAMYEQGLISAPVFSFYLNRDPASPEGGEIIFGGSDPNHYTGEFTYLPVTRK 250
            |..:|..........|..:|.:|.|:|..||.....| .||:|:|||.|.|.||||.|::|||::
Mouse   187 YPGLSSGGATTALQGMLGEGALSQPLFGVYLGSQQGS-NGGQIVFGGVDENLYTGELTWIPVTQE 250

  Fly   251 AYWQIKMDAASIGDLQ---LCKGGCQVIADTGTSLIAAPLEEATSINQKIGGTPIIGGQYVVSCD 312
            .||||.:|...||:..   ....|||.|.||||||:..|.:....:.|.||......|||.||||
Mouse   251 LYWQITIDDFLIGNQASGWCSSSGCQGIVDTGTSLLVMPAQYLNELLQTIGAQEGEYGQYFVSCD 315

  Fly   313 LIPQLPVIKFVLGGKTFELEGKDYILRVAQMGKTICLSGFMGLDIPPPNG-PLWILGDVFIGKYY 376
            .:..||.:.|||.|..|.|....||::  :.|.  |:.|...|.:...:| |||||||||:..||
Mouse   316 SVSSLPTLTFVLNGVQFPLSPSSYIIQ--EEGS--CMVGLESLSLNAESGQPLWILGDVFLRSYY 376

  Fly   377 TEFDMGNDRVGFA 389
            ..|||||:|||.|
Mouse   377 AVFDMGNNRVGLA 389

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cathD	NP_652013.1	A1_Propeptide	29..56	CDD:462326	9/27 (33%)
		pepsin_retropepsin_like	62..389	CDD:472175	152/330 (46%)
Pgc	NP_080249.2	A1_Propeptide	20..46	CDD:462326	9/25 (36%)
		pepsin_retropepsin_like	73..391	CDD:472175	149/324 (46%)