DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cathD and ctse

DIOPT Version :9

Sequence 1:	NP_001334713.1	Gene:	cathD / 45268	FlyBaseID:	FBgn0029093	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	NP_001120469.1	Gene:	ctse / 100145572	XenbaseID:	XB-GENE-947864	Length:	397	Species:	Xenopus tropicalis

Alignment Length:	401	Identity:	186/401 - (46%)
Similarity:	252/401 - (62%)	Gaps:	28/401 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQKVALLLVAFLAAAVAHPNSQEKPGLLRVPLHKFQSARRHFADVG------TELQQLRIRY--- 56
            |:::.|||   |.|.:.:       ||:||||.:.:|.|:...:.|      |:.....|:|
Frog     1 MRQILLLL---LFATLVY-------GLIRVPLKRQKSIRKKLKEKGKLSHVWTQQGIDMIQYTDS 55

  Fly    57 -GGGDVP-EPLSNYMDAQYYGPIAIGSPPQNFRVVFDTGSSNLWVPSKKCHLTNIACLMHNKYDA 119
             .....| |||.||||.:|:|.|:||:|||||.|:||||||||||||..|  .:.||..||::..
Frog    56 CSNNQAPSEPLINYMDVEYFGEISIGTPPQNFTVIFDTGSSNLWVPSVYC--ISPACAQHNRFQP 118

  Fly   120 SKSKTYTKNGTEFAIQYGSGSLSGYLSTDTVSIAGLDIKDQTFAEALSEPGLVFVAAKFDGILGL 184
            ..|.||..||..|::|||:|||||.:.||:||:.|:.::.|.|.|::||||..||.|:|||||||
Frog   119 QFSSTYQSNGNNFSLQYGTGSLSGIIGTDSVSVEGILVQSQQFGESVSEPGSTFVDAEFDGILGL 183

  Fly   185 GYNSISVDKVKPPFYAMYEQGLISAPVFSFYLNRDPASPEGGEIIFGGSDPNHYTGEFTYLPVTR 249
            ||.||:|....|.|..|..|.|:..|:||.|::|:|.||.|||::|||.|.:.::|:..::.||.
Frog   184 GYPSIAVGDCTPVFDNMMTQNLVELPMFSVYMSRNPNSPVGGELVFGGFDASRFSGQLNWVSVTN 248

  Fly   250 KAYWQIKMDAASI-GDLQLCKGGCQVIADTGTSLIAAPLEEATSINQKIGGTPIIGGQYVVSCDL 313
            :.||||::|...| |::..|.||||.|.|||||||..|..:...: |.|.|.....|.|.|.|.:
Frog   249 QGYWQIQLDNIQINGEVVFCTGGCQAIVDTGTSLITGPSSDIVQL-QSIIGASAANGDYEVDCSV 312

  Fly   314 IPQLPVIKFVLGGKTFELEGKDYILRVAQMGKTICLSGFMGLDIPPPNGPLWILGDVFIGKYYTE 378
            :.::|.:.|.:.|..:::..:.|.|   |.|..||.|||.||||.||.||||||||||||:||:.
Frog   313 LNEMPTVTFTINGIGYQMTPQQYTL---QDGGGICSSGFQGLDISPPAGPLWILGDVFIGQYYSV 374

  Fly   379 FDMGNDRVGFA 389
            ||.||:|||.|
Frog   375 FDRGNNRVGLA 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cathD	NP_001334713.1	None
ctse	NP_001120469.1	A1_Propeptide	17..42	CDD:369623	8/24 (33%)
ctse	NP_001120469.1	pepsin_retropepsin_like	74..386	CDD:386101	160/318 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X163
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.110