DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment deltaCOP and RET2

DIOPT Version :9

Sequence 1:	NP_652012.1	Gene:	deltaCOP / 45250	FlyBaseID:	FBgn0028969	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_116709.3	Gene:	RET2 / 850612	SGDID:	S000001947	Length:	546	Species:	Saccharomyces cerevisiae

Alignment Length:	571	Identity:	182/571 - (31%)
Similarity:	290/571 - (50%)	Gaps:	70/571 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVLIAAAVCTKNGKVILSRQFVEMTKARIEGLLAAFPKLMT-AGKQHTYVETDSVRYVYQPMEKL 64
            ||::||::.|:.||.:|||||.:::|.|:..||:.|..|:: ....||:||...|||||:|.:..
Yeast     1 MVVLAASITTRQGKPLLSRQFKDLSKDRVLELLSNFQNLVSEISSDHTFVEDKHVRYVYRPFDNY 65

  Fly    65 YMLLITTKASNILEDLETLRLFSKVIPEYSHSLDEKEIVENAFNLIFAFDEIVAL-GYRESVNLA 128
            |::|||.:.|||::||.||.|||:.|..|..|..::||..|||.::.:|||||:: ||:|:::..
Yeast    66 YIILITNRQSNIIKDLATLNLFSQTINSYLSSFQDQEIFHNAFEILSSFDEIVSMGGYKENLSFT 130

  Fly   129 QIKTFVEMDSHEEKVYQAVRQTQERDARQKMREKAKELQRQRMEASKRGGPSLGG--------IG 185
            |::|::.|:||||::.:.:.:.:|.:|.::.:.:|||:.|:..| .|.|..|..|        :|
Yeast   131 QVQTYLSMESHEERIQEIIERNKEIEATEERKRRAKEIARKEHE-RKHGFMSSNGDYDGANRFMG 194

  Fly   186 SRSGGFS---------ADGIGSSGVSSSSGASSANTGITSIDVDTKSKAAASKPASRNALKLGGK 241
            |:....:         |..........||.|::|.....:..:.|..:|..|   :...:||||
Yeast   195 SKDPNVTNAINSYYSHASPAAQQSYLQSSHAAAAEVAPVASPMATSQRAGHS---ATGGMKLGG- 255

  Fly   242 SKDVDSFVDQLKNEGEKIANLAPAAPAGGSSAAASASAAAKAAIASDI-HKESVHLKIEDKLVVR 305
                        ..|.:    |.|||.  .||.:|||:........|: ....:.:.|::.:...
Yeast   256 ------------GAGRR----AGAAPR--PSAISSASSGTPPPPEEDVPENNGILISIKEVINAE 302

  Fly   306 LGRDGGVQQFENSGLLTLRITDEAYGRILLKLSPN---HTQGLQLQTHPNVDKELFKSRTTIGLK 367
            ..|||.:...|..|:|.|||.|.......|||:.:   ..:..|.:||||:||:.|.|...|.|:
Yeast   303 FSRDGTIHSSELKGVLELRINDHDLSHSNLKLADSIDVRDKSFQFKTHPNIDKQSFLSTKLISLR 367

  Fly   368 NLGKPFPLN-TDVGVLKWRFV--SQDESAVPLTINCW--PSDNGEGGCDVNIEYELEAQQLELQD 427
            :..|.||.| ..:|||:||.|  ::|:|.:|||:..|  ||:: :.|.||.|||| ...:.||.|
Yeast   368 DKSKAFPANDQSLGVLRWRKVAPAEDDSLIPLTLTTWVSPSES-QQGFDVIIEYE-SVLETELAD 430

  Fly   428 VAIVI------PLPMNVQPSVAEYDGTYNYDSRKHVLQWHIPIID-AANKSGSMEFSCSASIPGD 485
            |...|      |:.:|.:.|........|.|..   :...|.|.. |||.:|::.|:..|.....
Yeast   431 VIFTIPVFPQEPVDINTESSTCSDAEVVNMDQE---MGTSIKISKIAANDAGALAFTIEAPYEDA 492

  Fly   486 FFPLQVSFVSKT------PYAGVVAQDVVQV-DSEAAVKYSSESILFVEKY 529
            .:|:.|||...|      .:.|:..|.||.. |.:..:.|...:.|..::|
Yeast   493 LYPMTVSFQESTRDKLAKSFTGMAIQSVVMANDHDQELPYDVITSLKSDEY 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
deltaCOP	NP_652012.1	AP_delta-COPI_MHD	292..529	CDD:271162	80/258 (31%)
RET2	NP_116709.3	Delta_COP_N	4..135	CDD:341434	57/130 (44%)
RET2	NP_116709.3	AP_delta-COPI_MHD	289..543	CDD:271162	80/258 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344248
Domainoid	1	1.000	107	1.000	Domainoid score	I1439
eggNOG	1	0.900	-	-		E1_KOG2635
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	243	1.000	Inparanoid score	I681
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54088
OrthoFinder	1	1.000	-	-		FOG0003612
OrthoInspector	1	1.000	-	-		oto99607
orthoMCL	1	0.900	-	-		OOG6_101729
Panther	1	1.100	-	-	LDO	PTHR10121
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R228
SonicParanoid	1	1.000	-	-		X2487
TreeFam	1	0.960	-	-
	14	13.790