DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment deltaCOP and arcn1

DIOPT Version :9

Sequence 1:	NP_652012.1	Gene:	deltaCOP / 45250	FlyBaseID:	FBgn0028969	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_001016978.1	Gene:	arcn1 / 549732	XenbaseID:	XB-GENE-986163	Length:	513	Species:	Xenopus tropicalis

Alignment Length:	536	Identity:	310/536 - (57%)
Similarity:	391/536 - (72%)	Gaps:	27/536 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVLIAAAVCTKNGKVILSRQFVEMTKARIEGLLAAFPKLMTAGKQHTYVETDSVRYVYQPMEKLY 65
            |||:|||||||.||.|:||||||||:.|||||||||||||..|||||:|||:|||||||||||||
Frog     1 MVLLAAAVCTKAGKAIVSRQFVEMTRTRIEGLLAAFPKLMNTGKQHTFVETESVRYVYQPMEKLY 65

  Fly    66 MLLITTKASNILEDLETLRLFSKVIPEYSHSLDEKEIVENAFNLIFAFDEIVALGYRESVNLAQI 130
            |:|||||.||||||||||||||:|||||..:|:|.||.::.|:|||||||||||||||:||||||
Frog    66 MVLITTKNSNILEDLETLRLFSRVIPEYCRALEETEISDHCFDLIFAFDEIVALGYRENVNLAQI 130

  Fly   131 KTFVEMDSHEEKVYQAVRQTQERDARQKMREKAKELQRQRMEASKRG--GPSLGGIGSRSGGFSA 193
            :||.|||||||||::|||:||||:|:.:||.||||||:.|.:|.::|  .|..||.||
Frog   131 RTFTEMDSHEEKVFRAVRETQEREAKAEMRRKAKELQQARRDAERQGKKAPGFGGFGS------- 188

  Fly   194 DGIGSSGVSSSSGASSANTGITSIDVDTKSKAAASKPA-SRNALKLGGKSKDVDSFVDQLKNEGE 257
                |.|.|.|:.|.|..|........|||....|:|: |..|||||.|.|:||:|||:||:|||
Frog   189 ----SGGSSMSNNAVSLITETIIEPEKTKSAPVPSRPSGSGKALKLGAKGKEVDNFVDKLKSEGE 249

  Fly   258 KIANLAPAAPAGGSSAAASASAAAKAAIASDIHKESVHLKIEDKLVVRLGRDGGVQQFENSGLLT 322
            .|     ..|:.|.    ..|..|| .:|..::.|||||::|:|:.:...||||:|..|..||:.
Frog   250 TI-----VTPSSGK----RQSEVAK-VLAPPVNMESVHLRVEEKISLTCSRDGGLQNMEVHGLIM 304

  Fly   323 LRITDEAYGRILLKLSPNHTQGLQLQTHPNVDKELFKSRTTIGLKNLGKPFPLNTDVGVLKWRFV 387
            ||:||:.:|||.:.:.....:|:||||||||||:||.|.:.|||||..|.||||:||||||||..
Frog   305 LRVTDDKFGRIRVHIENEDKKGVQLQTHPNVDKKLFTSDSVIGLKNPEKSFPLNSDVGVLKWRLQ 369

  Fly   388 SQDESAVPLTINCWPSDNGEGGCDVNIEYELEAQQLELQDVAIVIPLPMNV-QPSVAEYDGTYNY 451
            :.|||.:|||||||||::| .||||||||||:.::|||.||.|.||||..| .|.:.:.||.|::
Frog   370 TTDESFIPLTINCWPSESG-NGCDVNIEYELQEERLELNDVVITIPLPAGVGSPVIGDIDGDYHH 433

  Fly   452 DSRKHVLQWHIPIIDAANKSGSMEFSCSASIPGDFFPLQVSFVSKTPYAGVVAQDVVQVDSEAAV 516
            |||::.|:|.:|:||:.||:||:|||. |..|.||||:.||||||..|..:....|.|||..::|
Frog   434 DSRRNTLEWTLPVIDSKNKTGSLEFSI-AGHPNDFFPVTVSFVSKKNYCSLHVTKVTQVDGNSSV 497

  Fly   517 KYSSESILFVEKYEIV 532
            ::|:|:...|:||||:
Frog   498 RFSTETSFLVDKYEIL 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
deltaCOP	NP_652012.1	AP_delta-COPI_MHD	292..529	CDD:271162	128/237 (54%)
arcn1	NP_001016978.1	Delta_COP_N	4..133	CDD:341434	103/128 (80%)
arcn1	NP_001016978.1	AP_delta-COPI_MHD	274..510	CDD:271162	128/237 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	228	1.000	Domainoid score	I2437
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1250
Inparanoid	1	1.050	579	1.000	Inparanoid score	I1019
OMA	1	1.010	-	-		QHG54088
OrthoDB	1	1.010	-	-		D1027200at2759
OrthoFinder	1	1.000	-	-		FOG0003612
OrthoInspector	1	1.000	-	-		oto103758
Panther	1	1.100	-	-	LDO	PTHR10121
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R228
SonicParanoid	1	1.000	-	-		X2487
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110