DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment deltaCOP and arcn1b

DIOPT Version :9

Sequence 1:	NP_652012.1	Gene:	deltaCOP / 45250	FlyBaseID:	FBgn0028969	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_973722.1	Gene:	arcn1b / 399661	ZFINID:	ZDB-GENE-040121-7	Length:	512	Species:	Danio rerio

Alignment Length:	537	Identity:	312/537 - (58%)
Similarity:	392/537 - (72%)	Gaps:	30/537 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVLIAAAVCTKNGKVILSRQFVEMTKARIEGLLAAFPKLMTAGKQHTYVETDSVRYVYQPMEKLY 65
            |||:|||||||.||.|:||||||||:.|:|||||||||||..|||||:||||||||||||:||||
Zfish     1 MVLLAAAVCTKAGKAIVSRQFVEMTRTRVEGLLAAFPKLMNTGKQHTFVETDSVRYVYQPLEKLY 65

  Fly    66 MLLITTKASNILEDLETLRLFSKVIPEYSHSLDEKEIVENAFNLIFAFDEIVALGYRESVNLAQI 130
            |:|||||.||||||||||||||:|||||...|:|.||.|:.|:|||||||||||||||:||||||
Zfish    66 MVLITTKNSNILEDLETLRLFSRVIPEYCRVLEESEISEHCFDLIFAFDEIVALGYRENVNLAQI 130

  Fly   131 KTFVEMDSHEEKVYQAVRQTQERDARQKMREKAKELQRQRMEASKRGGPSLGGIGSRSGGFSADG 195
            :||.|||||||||::|||:||||:|:.:|:.|||||||.|.:|.:        .|.:|.||.  |
Zfish   131 RTFTEMDSHEEKVFRAVRETQEREAKAEMKRKAKELQRARQDAER--------AGKKSPGFG--G 185

  Fly   196 IGSSGVSSSSGASSANTGITSIDVDTKSKAAAS--KPA-SRNALKLGGKSKDVDSFVDQLKNEGE 257
            .||||:||.:.|    |.||......|.|.|.:  :|: |..|||||.|.|:||.|||:||:|||
Zfish   186 FGSSGMSSITSA----TIITDTIEPEKPKVAPASVRPSGSSKALKLGAKGKEVDFFVDKLKSEGE 246

  Fly   258 KIANLAPAAPAGGSSAAASASAAAKAAIASDIHKESVHLKIEDKLVVRLGRDGGVQQFENSGLLT 322
            .|..         :||...||.|:| .:...::.|||||::|:|:.:..|||||:|..|..|::|
Zfish   247 NIVT---------TSAGRKASEASK-VLQPPVNMESVHLRVEEKISLTCGRDGGLQNMEVLGMIT 301

  Fly   323 LRITDEAYGRILLKLSPNHTQGLQLQTHPNVDKELFKSRTTIGLKNLGKPFPLNTDVGVLKWRFV 387
            |::.||..|||::.::.|..:|.||||||:|||:||.:.:.|||||..|.||||:|:||||||..
Zfish   302 LKVADEKNGRIIIVVNNNDKKGAQLQTHPHVDKKLFTNESLIGLKNQEKSFPLNSDLGVLKWRLQ 366

  Fly   388 SQDESAVPLTINCWPSDNGEG-GCDVNIEYELEAQQLELQDVAIVIPLPMNV-QPSVAEYDGTYN 450
            |.|||.:|||||||||::|.| ||||||||||:.:.|||.||.|.||:|..| .|.|.:.||.||
Zfish   367 STDESLIPLTINCWPSESGSGSGCDVNIEYELQDEGLELNDVVITIPVPSGVGAPVVGDLDGQYN 431

  Fly   451 YDSRKHVLQWHIPIIDAANKSGSMEFSCSASIPGDFFPLQVSFVSKTPYAGVVAQDVVQVDSEAA 515
            :||||::|:|.:|:||..|||||:|||.... |.||||:.||||||..:..:....|..|:..:.
Zfish   432 HDSRKNILEWSLPVIDEKNKSGSLEFSIDGK-PNDFFPINVSFVSKRNFCDIQVAKVTYVEGGSP 495

  Fly   516 VKYSSESILFVEKYEIV 532
            ||:|||:...|:||||:
Zfish   496 VKFSSETSFVVDKYEIL 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
deltaCOP	NP_652012.1	AP_delta-COPI_MHD	292..529	CDD:271162	129/238 (54%)
arcn1b	NP_973722.1	AP_delta-COPI_MHD	271..509	CDD:271162	129/238 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582677
Domainoid	1	1.000	234	1.000	Domainoid score	I2319
eggNOG	1	0.900	-	-		E1_KOG2635
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	581	1.000	Inparanoid score	I986
OMA	1	1.010	-	-		QHG54088
OrthoDB	1	1.010	-	-		D1027200at2759
OrthoFinder	1	1.000	-	-		FOG0003612
OrthoInspector	1	1.000	-	-		otm24787
orthoMCL	1	0.900	-	-		OOG6_101729
Panther	1	1.100	-	-	O	PTHR10121
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R228
SonicParanoid	1	1.000	-	-		X2487
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800