DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment deltaCOP and Arcn1

DIOPT Version :9

Sequence 1:	NP_652012.1	Gene:	deltaCOP / 45250	FlyBaseID:	FBgn0028969	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_001007663.1	Gene:	Arcn1 / 300674	RGDID:	1359110	Length:	511	Species:	Rattus norvegicus

Alignment Length:	533	Identity:	309/533 - (57%)
Similarity:	385/533 - (72%)	Gaps:	23/533 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVLIAAAVCTKNGKVILSRQFVEMTKARIEGLLAAFPKLMTAGKQHTYVETDSVRYVYQPMEKLY 65
            |||:|||||||.||.|:||||||||:.|||||||||||||..|||||:|||:|||||||||||||
  Rat     1 MVLLAAAVCTKAGKAIVSRQFVEMTRTRIEGLLAAFPKLMNTGKQHTFVETESVRYVYQPMEKLY 65

  Fly    66 MLLITTKASNILEDLETLRLFSKVIPEYSHSLDEKEIVENAFNLIFAFDEIVALGYRESVNLAQI 130
            |:|||||.||||||||||||||:|||||..:|:|.||.|:.|:|||||||||||||||:||||||
  Rat    66 MVLITTKNSNILEDLETLRLFSRVIPEYCRALEENEISEHCFDLIFAFDEIVALGYRENVNLAQI 130

  Fly   131 KTFVEMDSHEEKVYQAVRQTQERDARQKMREKAKELQRQRMEASKRGGPSLGGIGSRSGGFSADG 195
            :||.|||||||||::|||:||||:|:.:||.||||||:.|.:|.::        |.::.||.  |
  Rat   131 RTFTEMDSHEEKVFRAVRETQEREAKAEMRRKAKELQQARRDAERQ--------GKKAPGFG--G 185

  Fly   196 IGSSGVSSSSGASSANTGITSIDVDTKSKAAASKPASRNALKLGGKSKDVDSFVDQLKNEGEKIA 260
            .|||.||..|.|:.....|...|....:.|.|.......|||||.|.|:||:|||:||:|||.|.
  Rat   186 FGSSAVSGGSTAAMITETIIETDKPKVAPAPARPSGPSKALKLGAKGKEVDNFVDKLKSEGETIM 250

  Fly   261 NLAPAAPAGGSSAAASASAAAKAAIASDIHKESVHLKIEDKLVVRLGRDGGVQQFENSGLLTLRI 325
            :         |:.....|.|||.. |..|:.||||:|||:|:.:..|||||:|..|..|::.|||
  Rat   251 S---------SNMGKRTSEAAKVH-APPINMESVHMKIEEKITLTCGRDGGLQNMELHGMIMLRI 305

  Fly   326 TDEAYGRILLKLSPNHTQGLQLQTHPNVDKELFKSRTTIGLKNLGKPFPLNTDVGVLKWRFVSQD 390
            :|:.:|||.|.:.....:|:||||||||||:||.:.:.|||||..|.||:|:||||||||..:.:
  Rat   306 SDDKFGRIRLHVENEDKKGVQLQTHPNVDKKLFTAESLIGLKNPEKSFPVNSDVGVLKWRLQTTE 370

  Fly   391 ESAVPLTINCWPSDNGEGGCDVNIEYELEAQQLELQDVAIVIPLPMNV-QPSVAEYDGTYNYDSR 454
            ||.:|||||||||::| .||||||||||:...|||.||.|.||||..| .|.:.|.||.|.:|||
  Rat   371 ESFIPLTINCWPSESG-NGCDVNIEYELQEDNLELNDVVITIPLPSGVGAPVIGEIDGEYRHDSR 434

  Fly   455 KHVLQWHIPIIDAANKSGSMEFSCSASIPGDFFPLQVSFVSKTPYAGVVAQDVVQVDSEAAVKYS 519
            ::.|:|.:|:|||.|||||:|||.... |.||||:||||:||..|..:....|.|||..:.|::|
  Rat   435 RNTLEWCLPVIDAKNKSGSLEFSIPGQ-PNDFFPVQVSFISKKNYCNIQVTKVTQVDGNSPVRFS 498

  Fly   520 SESILFVEKYEIV 532
            :|:...|:||||:
  Rat   499 TETTFLVDKYEIL 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
deltaCOP	NP_652012.1	AP_delta-COPI_MHD	292..529	CDD:271162	129/237 (54%)
Arcn1	NP_001007663.1	Delta_COP_N	4..133	CDD:341434	104/128 (81%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	168..188		6/29 (21%)
		AP_delta-COPI_MHD	272..508	CDD:271162	129/237 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342654
Domainoid	1	1.000	229	1.000	Domainoid score	I2398
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1250
Inparanoid	1	1.050	582	1.000	Inparanoid score	I977
OMA	1	1.010	-	-		QHG54088
OrthoDB	1	1.010	-	-		D1027200at2759
OrthoFinder	1	1.000	-	-		FOG0003612
OrthoInspector	1	1.000	-	-		oto97068
orthoMCL	1	0.900	-	-		OOG6_101729
Panther	1	1.100	-	-	LDO	PTHR10121
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2487
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910