DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment deltaCOP and Arcn1

DIOPT Version :9

Sequence 1:	NP_652012.1	Gene:	deltaCOP / 45250	FlyBaseID:	FBgn0028969	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_666097.3	Gene:	Arcn1 / 213827	MGIID:	2387591	Length:	511	Species:	Mus musculus

Alignment Length:	533	Identity:	307/533 - (57%)
Similarity:	383/533 - (71%)	Gaps:	23/533 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVLIAAAVCTKNGKVILSRQFVEMTKARIEGLLAAFPKLMTAGKQHTYVETDSVRYVYQPMEKLY 65
            |||:|||||||.||.|:||||||||:.|||||||||||||..|||||:|||:|||||||||||||
Mouse     1 MVLLAAAVCTKAGKAIVSRQFVEMTRTRIEGLLAAFPKLMNTGKQHTFVETESVRYVYQPMEKLY 65

  Fly    66 MLLITTKASNILEDLETLRLFSKVIPEYSHSLDEKEIVENAFNLIFAFDEIVALGYRESVNLAQI 130
            |:|||||.||||||||||||||:|||||..:|:|.||.|:.|:|||||||||||||||:||||||
Mouse    66 MVLITTKNSNILEDLETLRLFSRVIPEYCRALEENEISEHCFDLIFAFDEIVALGYRENVNLAQI 130

  Fly   131 KTFVEMDSHEEKVYQAVRQTQERDARQKMREKAKELQRQRMEASKRGGPSLGGIGSRSGGFSADG 195
            :||.|||||||||::|||:||||:|:.:||.||||||:.|.:|.::        |.::.||.  |
Mouse   131 RTFTEMDSHEEKVFRAVRETQEREAKAEMRRKAKELQQARRDAERQ--------GKKAPGFG--G 185

  Fly   196 IGSSGVSSSSGASSANTGITSIDVDTKSKAAASKPASRNALKLGGKSKDVDSFVDQLKNEGEKIA 260
            .|||.||..|.|:.....|...|....:.|.|.......|||||.|.|:||:|||:||:|||.|.
Mouse   186 FGSSAVSGGSTAAMITETIIETDKPKVAPAPARPSGPSKALKLGAKGKEVDNFVDKLKSEGETIM 250

  Fly   261 NLAPAAPAGGSSAAASASAAAKAAIASDIHKESVHLKIEDKLVVRLGRDGGVQQFENSGLLTLRI 325
                      ||.....::.|....|..|:.||||:|||:|:.:..|||||:|..|..|::.|||
Mouse   251 ----------SSNMGKRTSEATKVHAPPINMESVHMKIEEKITLTCGRDGGLQNMELHGMIMLRI 305

  Fly   326 TDEAYGRILLKLSPNHTQGLQLQTHPNVDKELFKSRTTIGLKNLGKPFPLNTDVGVLKWRFVSQD 390
            :|:.:|||.|.:.....:|:||||||||||:||.:.:.|||||..|.||:|:||||||||..:.:
Mouse   306 SDDKFGRIRLHVENEDKKGVQLQTHPNVDKKLFTAESLIGLKNPEKSFPVNSDVGVLKWRLQTTE 370

  Fly   391 ESAVPLTINCWPSDNGEGGCDVNIEYELEAQQLELQDVAIVIPLPMNV-QPSVAEYDGTYNYDSR 454
            ||.:|||||||||::| .||||||||||:...|||.||.|.||||..| .|.:.|.||.|.:|||
Mouse   371 ESFIPLTINCWPSESG-NGCDVNIEYELQEDNLELNDVVITIPLPSGVGAPVIGEIDGEYRHDSR 434

  Fly   455 KHVLQWHIPIIDAANKSGSMEFSCSASIPGDFFPLQVSFVSKTPYAGVVAQDVVQVDSEAAVKYS 519
            ::.|:|.:|:|||.|||||:|||.... |.||||:||||:||..|..:....|.|||..:.|::|
Mouse   435 RNTLEWCLPVIDAKNKSGSLEFSIPGQ-PNDFFPVQVSFISKKNYCNIQVTKVTQVDGNSPVRFS 498

  Fly   520 SESILFVEKYEIV 532
            :|:...|:||||:
Mouse   499 TETTFLVDKYEIL 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
deltaCOP	NP_652012.1	AP_delta-COPI_MHD	292..529	CDD:271162	129/237 (54%)
Arcn1	NP_666097.3	Delta_COP_N	4..133	CDD:341434	104/128 (81%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	168..188		6/29 (21%)
		AP_delta-COPI_MHD	272..508	CDD:271162	129/237 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838846
Domainoid	1	1.000	229	1.000	Domainoid score	I2474
eggNOG	1	0.900	-	-		E1_KOG2635
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1250
Inparanoid	1	1.050	581	1.000	Inparanoid score	I1011
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54088
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003612
OrthoInspector	1	1.000	-	-		oto93526
orthoMCL	1	0.900	-	-		OOG6_101729
Panther	1	1.100	-	-	LDO	PTHR10121
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R228
SonicParanoid	1	1.000	-	-		X2487
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790