DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eEF1beta and EFCC1

DIOPT Version :9

Sequence 1:	NP_001286506.1	Gene:	eEF1beta / 45249	FlyBaseID:	FBgn0028737	Length:	222	Species:	Drosophila melanogaster
Sequence 2:	NP_001364429.1	Gene:	EFCC1 / 79825	HGNCID:	25692	Length:	599	Species:	Homo sapiens

Alignment Length:	241	Identity:	51/241 - (21%)
Similarity:	90/241 - (37%)	Gaps:	85/241 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 RWYRHIASFEAAERAAWSGTPLPQLAGGKP------------------------TVAAAAKPAAD 94
            ||.|.:.:.....|:..|..|.||||..:|                        :.:::...|.|
Human   314 RWVRRLEAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAGTRDPDPTPEGAWQSDSSSGSRALD 378

  Fly    95 DDDDVDLFGS------DDEEDEEAERIKQERVAAYAAKKSKKPALIAKSSVLLDVKP----WDDE 149
            :..|..||.|      .|||:.|.||.::|:         |.||..|| ::|..:..    .||:
Human   379 EAVDEQLFRSVEGQAASDEEEVEEERWQEEK---------KTPAAEAK-TLLARLSSCRGRCDDQ 433

  Fly   150 TDMKEM--------ENNVRTI-EMDGLLWGASKLV-----------PVGYGINKLQI-------- 186
            |..|.|        .|:..|: |::..:   :.||           .:|....:.::
Human   434 TAEKLMTYFGHFGGANHAHTLGELEACI---AMLVEQLRTQGCGGRTLGTSEEEAELQQKVEENE 495

  Fly   187 -----MCVIEDDKVSIDLLQEKIEEFEDFVQ-----SVDIAAFNKI 222
                 :.::|.::|.:.||:||:.:....:|     ::...|..||
Human   496 HLRLELQMVETERVRLSLLEEKLVDVLQLLQRLRDLNISKRALGKI 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEF1beta	NP_001286506.1	GST_C_eEF1b_like	<3..62	CDD:198341	3/7 (43%)
eEF1beta	NP_001286506.1	EF1_GNE	139..222	CDD:279125	20/124 (16%)
EFCC1	NP_001364429.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		CCD48	18..599	CDD:406280	51/241 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	96..127
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	175..198
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159539
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11595
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.030