DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eEF1beta and EEF1B2

DIOPT Version :9

Sequence 1:	NP_001286506.1	Gene:	eEF1beta / 45249	FlyBaseID:	FBgn0028737	Length:	222	Species:	Drosophila melanogaster
Sequence 2:	NP_001032752.1	Gene:	EEF1B2 / 1933	HGNCID:	3208	Length:	225	Species:	Homo sapiens

Alignment Length:	230	Identity:	134/230 - (58%)
Similarity:	174/230 - (75%)	Gaps:	13/230 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAFGDVTTPQGLKELNAFLADNSYISGYTPSKADLSVFDALGKAPSADNVNVARWYRHIASFEAA 65
            |.|||:.:|.||:.||.:|||.|||.||.||:||::||:|:...|.||..:..|||.||.|:| .
Human     1 MGFGDLKSPAGLQVLNDYLADKSYIEGYVPSQADVAVFEAVSSPPPADLCHALRWYNHIKSYE-K 64

  Fly    66 ERAAWSGTPLPQLAGGK-------PTVAAAAKPAADDDDDVDLFGSDDEED-EEAERIKQERVAA 122
            |:|:..|.   :.|.||       .|..:.|.. :.||||:|||||||||: |||:|:::||:|.
Human    65 EKASLPGV---KKALGKYGPADVEDTTGSGATD-SKDDDDIDLFGSDDEEESEEAKRLREERLAQ 125

  Fly   123 YAAKKSKKPALIAKSSVLLDVKPWDDETDMKEMENNVRTIEMDGLLWGASKLVPVGYGINKLQIM 187
            |.:||:|||||:||||:|||||||||||||.::|..||:|:.|||:||:||||||||||.||||.
Human   126 YESKKAKKPALVAKSSILLDVKPWDDETDMAKLEECVRSIQADGLVWGSSKLVPVGYGIKKLQIQ 190

  Fly   188 CVIEDDKVSIDLLQEKIEEFEDFVQSVDIAAFNKI 222
            ||:|||||..|:|:|:|..|||:|||:|:||||||
Human   191 CVVEDDKVGTDMLEEQITAFEDYVQSMDVAAFNKI 225

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEF1beta	NP_001286506.1	GST_C_eEF1b_like	<3..62	CDD:198341	31/58 (53%)
eEF1beta	NP_001286506.1	EF1_GNE	139..222	CDD:279125	58/82 (71%)
EEF1B2	NP_001032752.1	GST_C_eEF1b_like	<3..62	CDD:198341	31/58 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	78..115		17/37 (46%)
		EF-1_beta_acid	103..130	CDD:402289	16/26 (62%)
		EF1_GNE	142..225	CDD:395597	58/82 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159538
Domainoid	1	1.000	137	1.000	Domainoid score	I4899
eggNOG	1	0.900	-	-		E1_COG2092
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1480
Inparanoid	1	1.050	262	1.000	Inparanoid score	I3096
Isobase	1	0.950	-	0	Normalized mean entropy	S637
OMA	1	1.010	-	-		QHG53756
OrthoDB	1	1.010	-	-		D1464823at2759
OrthoFinder	1	1.000	-	-		FOG0001111
OrthoInspector	1	1.000	-	-		oto88715
orthoMCL	1	0.900	-	-		OOG6_101695
Panther	1	1.100	-	-	LDO	PTHR11595
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R365
SonicParanoid	1	1.000	-	-		X680
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750