DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eEF1beta and eef-1B.1

DIOPT Version :9

Sequence 1:	NP_001286506.1	Gene:	eEF1beta / 45249	FlyBaseID:	FBgn0028737	Length:	222	Species:	Drosophila melanogaster
Sequence 2:	NP_498737.1	Gene:	eef-1B.1 / 176120	WormBaseID:	WBGene00018846	Length:	213	Species:	Caenorhabditis elegans

Alignment Length:	221	Identity:	129/221 - (58%)
Similarity:	155/221 - (70%)	Gaps:	14/221 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 DVTTPQGLKELNAFLADNSYISGYTPSKADLSVFDALGKAPSADNV-NVARWYRHIASFEAAERA 68
            ||.:|.||...|..||:.::.:|:..|..|..:|.|||.||:|... ||||||.::||:..|||.
Worm     4 DVKSPAGLAAFNTTLAEQAFATGFVLSGEDAQLFAALGSAPNASTYPNVARWYANVASYTDAERK 68

  Fly    69 AWSGTPLPQLAGGKPTVAAAAKPAADDDDDVDLFGSDD-EEDEEAERIKQERVAAYAAKKSKKPA 132
            .|:.      |||....||||     |.||.||||||| |||.|..:|.:||:||||.||:||..
Worm    69 TWAS------AGGSAPAAAAA-----DGDDFDLFGSDDEEEDAEKAKIVEERLAAYAEKKAKKAG 122

  Fly   133 LIAKSSVLLDVKPWDDETDMKEMENNVRTIEMDGLLWGASKLVPVGYGINKLQIMCVIEDDKVSI 197
            .||||||:|||||||||||:.|||..||:||||||:||.:||:|:||||.||||:.||||.|||:
Worm   123 PIAKSSVILDVKPWDDETDLGEMEKLVRSIEMDGLVWGGAKLIPIGYGIKKLQIITVIEDLKVSV 187

  Fly   198 DLLQEKIE-EFEDFVQSVDIAAFNKI 222
            |.|.|||. :|||.||||||.|||||
Worm   188 DDLIEKITGDFEDHVQSVDIVAFNKI 213

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEF1beta	NP_001286506.1	GST_C_eEF1b_like	<3..62	CDD:198341	25/57 (44%)
eEF1beta	NP_001286506.1	EF1_GNE	139..222	CDD:279125	60/83 (72%)
eef-1B.1	NP_498737.1	GST_C_family	<1..62	CDD:295467	25/57 (44%)
		EF-1_beta_acid	90..>110	CDD:287546	12/19 (63%)
		EF1_GNE	129..213	CDD:279125	60/83 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167115
Domainoid	1	1.000	126	1.000	Domainoid score	I3353
eggNOG	1	0.900	-	-		E1_COG2092
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1480
Inparanoid	1	1.050	232	1.000	Inparanoid score	I2174
Isobase	1	0.950	-	0	Normalized mean entropy	S637
OMA	1	1.010	-	-		QHG53756
OrthoDB	1	1.010	-	-		D1464823at2759
OrthoFinder	1	1.000	-	-		FOG0001111
OrthoInspector	1	1.000	-	-		otm40246
orthoMCL	1	0.900	-	-		OOG6_101695
Panther	1	1.100	-	-	LDO	PTHR11595
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R365
SonicParanoid	1	1.000	-	-		X680
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750