DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nckx30C and ECM27

DIOPT Version :9

Sequence 1:	NP_652011.3	Gene:	Nckx30C / 45248	FlyBaseID:	FBgn0028704	Length:	881	Species:	Drosophila melanogaster
Sequence 2:	NP_012640.4	Gene:	ECM27 / 853570	SGDID:	S000003867	Length:	725	Species:	Saccharomyces cerevisiae

Alignment Length:	745	Identity:	138/745 - (18%)
Similarity:	263/745 - (35%)	Gaps:	222/745 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   319 PKDLFTKEQLENGAVILHIIGVIYMFVALAIVCDEFFVPSL------------DVIIEKLGITDD 371
            |:.|:...:|....::..:..:|..||.|.|...:|..|::            ..::.|......
Yeast    10 PRLLYKDPKLSVTFIVPSLFHIIIAFVLLGICASDFLCPNVAHISDPNSLRSNGSLVSKTASHAS 74

  Fly   372 VAG---ATFMAAGGSAPELFTSVIGVFVSFDD-------VGIGTIVGSAVFNILFVIG-MCALFS 425
            ..|   |..::...|:|:||::::....|..:       :.||.::|:....:..|.| :..:.|
Yeast    75 HTGALMAVLLSWCNSSPDLFSNLMSWATSTRETRSTSVSLSIGEVLGACGIILCIVEGSIFIIMS 139

  Fly   426 KTVLSLTW---WPLFRDCSFYSISLLVLIYFFRDNRIFWWEALILFTIYIGYVAF---MKWNVQV 484
            :|.:.::.   ..:.||..|...::.|:.|....|::.....|::..:|..|:..   .|.|...
Yeast   140 RTHIEISQIQKLSIMRDLLFSLAAMCVMSYVSLMNQVTVLNCLLMAFLYAFYLVVKLTFKLNHSA 204

  Fly   485 ----ETCVKKMITKNKVTRVRSTDQLMPAG-----------------------------NAANSS 516
                ||.....:.:|.|:.... |.||.:|                             |:..|.
Yeast   205 ETPDETAADTSLRENSVSPFLD-DSLMASGLLPPIQPGFDISNSITHGIKPSLLSAMDFNSFLSM 268

  Fly   517 ETSMATQPGGSVTSRAASET-RSGPPG---SSNAGATGN-SSGGGGTSGSTQTGAKFRHGLLQLM 576
            ..:.:.:...|....|...| ||..||   |::|...|. :|.|...|..|....::|..  :..
Yeast   269 LENSSLEEDDSRNEMAELNTLRSMTPGQHWSASATVAGEATSAGRPFSEPTNAFTEYRDS--ERA 331

  Fly   577 IHT----IDPLHDGKVDEKATQLHAIASLKVLLDATKPQRGGA-------TTSAANHVKI----- 625
            |::    ..|..|...||::.:       :|||:.|.....||       ..|....:||
Yeast   332 INSSPAVFAPYRDNPDDEESQE-------QVLLETTTHGHFGAQEMRRFSKRSLGWIIKIFIPHL 389

  Fly   626 -NLKETTLAD-------------------RPNGNI---DTTLDSPSLSGRRPSWIEQRVKIQTRK 667
             |..:.:::|                   :|..:|   |.||:..||: ..|..:   :.||
Yeast   390 SNFSQKSISDAIFSIITVPFFIIFKLSCPQPPSDILSYDPTLNRYSLT-TLPIIL---LFIQ--- 447

  Fly   668 FSIKAP----EIEDEPEPLSMAWPDTARKRLTY-----VLVAPLLVPMWLTLPDT---------- 713
             ||.||    .|      ||:.        |||     |.:.||::.|.|.|..|
Yeast   448 -SITAPFLLCSI------LSVL--------LTYHLGYLVYLFPLILAMALILLLTAFITKVNLHN 497

  Fly   714 ------------RTPRGKR-------------FFPVTFIGSIVWIAAFSYLMVWWANVAGDTARI 753
                        :....||             |..:..|..|:||:..:..::....:......:
Yeast   498 KFTLSLDSSNILQEKLQKRKLLERLNTSIQIIFLAIGIINIIIWISLLANSLIEMMEIYQKILGL 562

  Fly   754 PPEVMGLTFLAAGTSIPDLITSVIVAR---------------KGFGDMAVSSSVGSNIFDVTVGL 803
            ...::|||..|.|.|:.|||:::.:.|               ..|..::.:|.:|..:.:...|:
Yeast   563 SKAILGLTIFAWGNSVGDLISNISMCRLYKTQTHYQDRVRLATKFFMISCASCLGGVMLNSMGGI 627

  Fly   804 PIPWLLYGIIYGA----------PVEV-------NSVGMVCSITILFMMLVFVVMSIAC-----F 846
            ....|:..:..||          .|::       |::.....::.:|::|..:::.:..     .
Yeast   628 GFSGLVSMLFIGAFNDNEWWFLRKVKLQETSQLDNTLNYKFIVSCVFIILQIILLLLFFGGPNNI 692

  Fly   847 RWRMNKGL---GFTMFLLYFAFVAVSLMFE 873
            :.|:.|.:   |.:|..|:.....::::.|
Yeast   693 KRRLTKEMKLVGISMCGLWALATLINILLE 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nckx30C	NP_652011.3	Na_Ca_ex	336..480	CDD:279963	31/172 (18%)
Nckx30C	NP_652011.3	Na_Ca_ex	721..871	CDD:279963	31/189 (16%)
ECM27	NP_012640.4	ECM27	18..>225	CDD:223604	38/206 (18%)
		PLN03151	<544..637	CDD:215604	15/92 (16%)
		ECM27	<558..721	CDD:223604	26/162 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810