Protein Alignment Nckx30C and ECM27

DIOPT Version :10

• Sequence 1: NP_652011.3
• Gene: Nckx30C / 45248
• FlyBaseID: FBgn0028704
• Length: 881
• Species: Drosophila melanogaster
• Sequence 2: NP_012640.4
• Gene: ECM27 / 853570
• SGDID: S000003867
• Length: 725
• Species: Saccharomyces cerevisiae
• Alignment Length: 745
• Identity: 138/745 - (18%)
• Similarity: 263/745 - (35%)
• Gaps: 222/745 - (29%)

  Fly   319 PKDLFTKEQLENGAVILHIIGVIYMFVALAIVCDEFFVPSL------------DVIIEKLGITDD 371
            |:.|:...:|....::..:..:|..||.|.|...:|..|::            ..::.|......
Yeast    10 PRLLYKDPKLSVTFIVPSLFHIIIAFVLLGICASDFLCPNVAHISDPNSLRSNGSLVSKTASHAS 74

  Fly   372 VAG---ATFMAAGGSAPELFTSVIGVFVSFDD-------VGIGTIVGSAVFNILFVIG-MCALFS 425
            ..|   |..::...|:|:||::::....|..:       :.||.::|:....:..|.| :..:.|
Yeast    75 HTGALMAVLLSWCNSSPDLFSNLMSWATSTRETRSTSVSLSIGEVLGACGIILCIVEGSIFIIMS 139

  Fly   426 KTVLSLTW---WPLFRDCSFYSISLLVLIYFFRDNRIFWWEALILFTIYIGYVAF---MKWNVQV 484
            :|.:.::.   ..:.||..|...::.|:.|....|::.....|::..:|..|:..   .|.|...
Yeast   140 RTHIEISQIQKLSIMRDLLFSLAAMCVMSYVSLMNQVTVLNCLLMAFLYAFYLVVKLTFKLNHSA 204

  Fly   485 ----ETCVKKMITKNKVTRVRSTDQLMPAG-----------------------------NAANSS 516
                ||.....:.:|.|:.... |.||.:|                             |:..|.
Yeast   205 ETPDETAADTSLRENSVSPFLD-DSLMASGLLPPIQPGFDISNSITHGIKPSLLSAMDFNSFLSM 268

  Fly   517 ETSMATQPGGSVTSRAASET-RSGPPG---SSNAGATGN-SSGGGGTSGSTQTGAKFRHGLLQLM 576
            ..:.:.:...|....|...| ||..||   |::|...|. :|.|...|..|....::|..  :..
Yeast   269 LENSSLEEDDSRNEMAELNTLRSMTPGQHWSASATVAGEATSAGRPFSEPTNAFTEYRDS--ERA 331

  Fly   577 IHT----IDPLHDGKVDEKATQLHAIASLKVLLDATKPQRGGA-------TTSAANHVKI----- 625
            |::    ..|..|...||::.:       :|||:.|.....||       ..|....:||
Yeast   332 INSSPAVFAPYRDNPDDEESQE-------QVLLETTTHGHFGAQEMRRFSKRSLGWIIKIFIPHL 389

  Fly   626 -NLKETTLAD-------------------RPNGNI---DTTLDSPSLSGRRPSWIEQRVKIQTRK 667
             |..:.:::|                   :|..:|   |.||:..||: ..|..:   :.||
Yeast   390 SNFSQKSISDAIFSIITVPFFIIFKLSCPQPPSDILSYDPTLNRYSLT-TLPIIL---LFIQ--- 447

  Fly   668 FSIKAP----EIEDEPEPLSMAWPDTARKRLTY-----VLVAPLLVPMWLTLPDT---------- 713
             ||.||    .|      ||:.        |||     |.:.||::.|.|.|..|
Yeast   448 -SITAPFLLCSI------LSVL--------LTYHLGYLVYLFPLILAMALILLLTAFITKVNLHN 497

  Fly   714 ------------RTPRGKR-------------FFPVTFIGSIVWIAAFSYLMVWWANVAGDTARI 753
                        :....||             |..:..|..|:||:..:..::....:......:
Yeast   498 KFTLSLDSSNILQEKLQKRKLLERLNTSIQIIFLAIGIINIIIWISLLANSLIEMMEIYQKILGL 562

  Fly   754 PPEVMGLTFLAAGTSIPDLITSVIVAR---------------KGFGDMAVSSSVGSNIFDVTVGL 803
            ...::|||..|.|.|:.|||:::.:.|               ..|..::.:|.:|..:.:...|:
Yeast   563 SKAILGLTIFAWGNSVGDLISNISMCRLYKTQTHYQDRVRLATKFFMISCASCLGGVMLNSMGGI 627

  Fly   804 PIPWLLYGIIYGA----------PVEV-------NSVGMVCSITILFMMLVFVVMSIAC-----F 846
            ....|:..:..||          .|::       |::.....::.:|::|..:::.:..     .
Yeast   628 GFSGLVSMLFIGAFNDNEWWFLRKVKLQETSQLDNTLNYKFIVSCVFIILQIILLLLFFGGPNNI 692

  Fly   847 RWRMNKGL---GFTMFLLYFAFVAVSLMFE 873
            :.|:.|.:   |.:|..|:.....::::.|
Yeast   693 KRRLTKEMKLVGISMCGLWALATLINILLE 722

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nckx30C	NP_652011.3	2A1904	<318..880	CDD:273344	138/745 (19%)
ECM27	NP_012640.4	Na_Ca_ex	27..196	CDD:426387	31/168 (18%)
		PLN03151	<544..637	CDD:215604	15/92 (16%)