DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nckx30C and Slc24a3

DIOPT Version :9

Sequence 1:	NP_652011.3	Gene:	Nckx30C / 45248	FlyBaseID:	FBgn0028704	Length:	881	Species:	Drosophila melanogaster
Sequence 2:	NP_445957.2	Gene:	Slc24a3 / 85267	RGDID:	69256	Length:	642	Species:	Rattus norvegicus

Alignment Length:	620	Identity:	223/620 - (35%)
Similarity:	331/620 - (53%)	Gaps:	98/620 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   302 INDT---------HNDNSTTTKTPLFPKDLFTKEQLENGAVILHIIGVIYMFVALAIVCDEFFVP 357
            :|||         .:.|.|......||:|:|:.|....|||:||::..:|||.|||||||:||||
  Rat    69 VNDTLTSEDAGLRSSKNCTEPALHEFPRDIFSNEDRRQGAVVLHVLCAMYMFYALAIVCDDFFVP 133

  Fly   358 SLDVIIEKLGITDDVAGATFMAAGGSAPELFTSVIGVFVSFDDVGIGTIVGSAVFNILFVIGMCA 422
            ||:.|.|:|.:::|||||||||||.|||||||||||||::..|||:||||||||||||.:||:|.
  Rat   134 SLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFNILCIIGVCG 198

  Fly   423 LFSKTVLSLTWWPLFRDCSFYSISLLVLIYFFRDNRIFWWEALILFTIYIGYVAFMKWNVQVETC 487
            ||:..|::|:.|.|.||..:|::|::.||.|..|.::.|||:|:|..:|:.|:..||:|..:..|
  Rat   199 LFAGQVVALSSWCLLRDSIYYTLSVVALIVFIYDEKVSWWESLVLVLMYLIYIIIMKYNACIHQC 263

  Fly   488 VKKMITKNKVTRVRSTDQLMPAGNAANSSETSMATQPGGSVTSRAASETRSGPPGSSNAGATGNS 552
            .::. ||.             |||..|                           |.:|.....:|
  Rat   264 FERR-TKG-------------AGNMVN---------------------------GLANNAEIDDS 287

  Fly   553 SGGGGTSGSTQTGAKFRHGLLQLMIHTIDPLHDGKVDEKATQL-HAI----ASLKVLLDATKPQR 612
            |....|....:. |.|......:|           |||..:.. |.:    |.|::::.:..|.:
  Rat   288 SNCDATVVLLKK-ANFHRKASVIM-----------VDELLSAYPHQLSFSEAGLRIMITSHFPPK 340

  Fly   613 GGATTSAANHVKINLKETTLADR--PNGNIDTTLDSPSL----SGRRPSWIEQRVKIQTRKFSIK 671
              ...|.|:.:.||.::..:..|  .||..:..:..|..    :|..||....|....||:..|.
  Rat   341 --TRLSMASRMLINERQRLINSRAYTNGESEVAIKIPIKHTVENGTGPSSAPDRGVNGTRRDDIV 403

  Fly   672 A-------------------PEIEDEPE-PLSMAWPDTAR-KRLTYVLVAPLLVPMWLTLPDTRT 715
            |                   .|.||:.| |.:...|.:.: :.:.:....||...::.|:|:...
  Rat   404 AEADNETENENEDENNENDEEEDEDDDEGPYTPFDPPSGKLETVKWAFTWPLSFVLYFTVPNCNK 468

  Fly   716 PRGKRFFPVTFIGSIVWIAAFSYLMVWWANVAGDTARIPPEVMGLTFLAAGTSIPDLITSVIVAR 780
            |..:::|.|||..|.:|||||||:|||...:.|.|..||..:||:||||||||:||.:.|:||||
  Rat   469 PHWEKWFMVTFASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVAR 533

  Fly   781 KGFGDMAVSSSVGSNIFDVTVGLPIPWLL--YGIIYGAPVEVNSVGMVCSITILFMMLVFVVMSI 843
            :|.||||||:|:|||:||:.:||.:||.|  ..:.||:.:.:||.|::.|:.:|...:...|..:
  Rat   534 QGMGDMAVSNSIGSNVFDILIGLGLPWALQTLAVDYGSYIRLNSRGLIYSVGLLLASVFVTVFGV 598

  Fly   844 ACFRWRMNKGLGFTMFLLYFAFVAVSLMFEYDVIT 878
            ...:|:::|.||.....||..|:..|:|.|::|.|
  Rat   599 HLNKWQLDKKLGCGCLFLYGVFLCFSIMTEFNVFT 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nckx30C	NP_652011.3	Na_Ca_ex	336..480	CDD:279963	84/143 (59%)
Nckx30C	NP_652011.3	Na_Ca_ex	721..871	CDD:279963	70/151 (46%)
Slc24a3	NP_445957.2	TIGR00367	111..604	CDD:273039	198/547 (36%)
		Na_Ca_ex	112..254	CDD:279963	83/141 (59%)
		Na_Ca_ex	474..626	CDD:279963	70/151 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1168500at2759
OrthoFinder	1	1.000	-	-		FOG0000196
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920