DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nckx30C and YDL206W

DIOPT Version :9

Sequence 1:	NP_652011.3	Gene:	Nckx30C / 45248	FlyBaseID:	FBgn0028704	Length:	881	Species:	Drosophila melanogaster
Sequence 2:	NP_010075.1	Gene:	YDL206W / 851321	SGDID:	S000002365	Length:	762	Species:	Saccharomyces cerevisiae

Alignment Length:	755	Identity:	143/755 - (18%)
Similarity:	267/755 - (35%)	Gaps:	235/755 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   330 NGAV---ILHIIGVIYMFVALAIVCDEFFVPSLDVIIEKL-GITDDVAGATFMAAGGSAPELFTS 390
            ||::   .||.:.:|..|..|.:|..:...|||..|...: .|:|.|:|.|.:|.|.:.|::.::
Yeast    28 NGSISEFYLHSVVLIECFSLLGVVTSDCLTPSLSYISSNIFHISDRVSGMTLLALGNALPDITST 92

  Fly   391 VIGVFVSFDDVGIGTIVGSAVFNILFVIGMCALFS-------KTV-----------LSLTWWPLF 437
            ...:......:.||.:.|...|.:..|||:....:       |::           ||.......
Yeast    93 YQSMKSGVTSLAIGELFGGIFFLLTVVIGLMGCVATIQFQHDKSIETYTEESFDQNLSYDRSNYI 157

  Fly   438 RDCSFYSISLLVLIYFFRDNRIFWWEALILFTIYIGYVAFM----KWNVQV------ETCVKKMI 492
            .|...::..|||...|..|.|:::||.:::...|.....::    |:..::      |..:||.:
Yeast   158 LDVGIFTFMLLVSGTFLADGRLYFWECIVMVLTYCCCAVYLIKSYKYPCEINDALEREVEIKKTV 222

  Fly   493 TKNK------------VTRVRSTDQ----LMPAGNAANSSETSMATQPGGSVTSRAASET----- 536
            ..|.            .:.:.|||.    :.|.|:.....:.:::..|     :|..|::
Yeast   223 LANNHITVPNRFTLTTTSDITSTDDGIRYVRPLGDTQIDEDNAISLDP-----TRLPSKSLDNIS 282

  Fly   537 --RSGPPGSSN------AGATGNSSGG-------------------GGTSGSTQTGAKFRH---- 570
              ..|.|...:      .|...:...|                   ..|..|....:...|
Yeast   283 RFNQGIPERRDLIRRRIRGYLRSHYHGWVRMTLQDLLNIWEKQNLFNNTVKSLSLPSDDTHLFTK 347

  Fly   571 --------GLLQLMIHTIDP--------LHDGK-----------------------------VDE 590
                    .|::..::::.|        |.:|:                             |.:
Yeast   348 ASLDEEGRPLIRKRMNSLQPKDFYKYLSLRNGENSNALDTAISAPQNEYQTYYNEPTSLFLTVPQ 412

  Fly   591 KATQLHAIA---------SLKVLL--DATKPQRGGATTSAANHVKINLKETTLA-DRPNGNIDTT 643
            |.|...:::         |..::|  :||:.|.   :|:|.|.:...:..:.|. :|.:..:|.|
Yeast   413 KKTSKKSLSCDRIPNLVRSNNIILNDEATRTQE---STNALNSISDVIDNSLLQYERDDIILDRT 474

  Fly   644 LDSPSLSGRRPSW------------------IEQRVKIQTRKFSI----KAP-EIE--DEPEPLS 683
            |...|... |.:|                  .|....:.|...||    ..| ||.  |...|||
Yeast   475 LSLCSTKS-RTAWHSFQLYNYLTDVSLEIGFFEFLSLLVTTPVSIILYLSIPSEISQTDHDLPLS 538

  Fly   684 -------MAWPDTARKRLT-----YVLVAPLLVPMWLTLPDTRTPRGK----RFFPVTFIGSIVW 732
                   :|.|....:.:|     ::|:..|::.:.|.. .|||...|    ..|.|.|:.|:..
Yeast   539 YLQNIQLIASPIILNQLITNNFSFWLLILSLVIAILLYF-KTRTIPNKFNSDIIFTVAFLLSLAC 602

  Fly   733 IAAFSYLMV----WWANVAGDTARIPPEVMGLTFLAAGTSIPDLITSVIVARKGFGDMAVSSSVG 793
            ::...:::|    .|.||    ..|...::|||....|.||.||::::...:.|..::|:.:..|
Yeast   603 LSKAVHIIVVTLTHWINV----FNISETILGLTIFTWGNSIGDLVSNITFVKIGVLEIAIGACFG 663

  Fly   794 SNIFDVTVGLPIPWLLYGIIY-GAPVEV-NSVGMVCS-----------------------ITILF 833
            |         |:.:.|:|:.: |..:.: :..|.:.|                       :.||.
Yeast   664 S---------PLLYFLFGVGFDGIMIMLGDKTGKIVSGRDSNILMHHIDFKVDKNLINTGVGILI 719

  Fly   834 MMLVFVVMSIACFRWRMNKGLGFTMFLLYFAFVAVSLMFE 873
            ..|:|.|: |....|:::|.:...:..||.....:|:..|
Yeast   720 AFLIFTVL-IPLNDWKIDKKISIALLTLYIVVTCISVFLE 758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nckx30C	NP_652011.3	Na_Ca_ex	336..480	CDD:279963	37/166 (22%)
Nckx30C	NP_652011.3	Na_Ca_ex	721..871	CDD:279963	38/178 (21%)
YDL206W	NP_010075.1	ECM27	28..>223	CDD:223604	44/194 (23%)
YDL206W	NP_010075.1	ECM27	<543..757	CDD:223604	48/228 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	55	1.000	Domainoid score	I2726
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	94	1.000	Inparanoid score	I1510
Isobase	1	0.950	-	0	Normalized mean entropy	S2929
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.810