Protein Alignment Nckx30C and Slc24a2

DIOPT Version :10

• Sequence 1: NP_652011.3
• Gene: Nckx30C / 45248
• FlyBaseID: FBgn0028704
• Length: 881
• Species: Drosophila melanogaster
• Sequence 2: NP_113931.1
• Gene: Slc24a2 / 84550
• RGDID: 628650
• Length: 670
• Species: Rattus norvegicus
• Alignment Length: 731
• Identity: 338/731 - (46%)
• Similarity: 434/731 - (59%)
• Gaps: 116/731 - (15%)

  Fly   183 SRSRCR----SRRCLRLPIYSILLLCLTTQGLGLGDAAKPRPAKQHFGGSNSNSPNQNQNHNDVL 243
            |.|.||    :|:.|:|         :...||.:|..|...........:.:.|.|.....:||.
  Rat    20 SPSGCRRHYNTRKKLKL---------IRVIGLVMGLVAVSTVPFSISAFTETYSQNNRGEASDVT 75

  Fly   244 GGVGAPSQTSGEDEAEIMYPFQSGEQMFGLEE---DQEQDPELNSNAVPGSDEDNAGNQRGINDT 305
            |...||....              ..:..|.:   |....|       |.|.||.:.|  |.:..
  Rat    76 GPRAAPGHRQ--------------RTLLDLNDKIRDYTPQP-------PASQEDRSEN--GTDHA 117

  Fly   306 HNDNSTTTKTPLFPKDLFTKEQLENGAVILHIIGVIYMFVALAIVCDEFFVPSLDVIIEKLGITD 370
            ..|         :|||:|:.|:...||:|||:||:||||:||||||||||||||.||.|||||:|
  Rat   118 QGD---------YPKDVFSLEERRKGAIILHVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISD 173

  Fly   371 DVAGATFMAAGGSAPELFTSVIGVFVSFDDVGIGTIVGSAVFNILFVIGMCALFSKTVLSLTWWP 435
            ||||||||||||||||||||:||||::..:|||||||||||||||||||||||||:.:|:|||||
  Rat   174 DVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSREILNLTWWP 238

  Fly   436 LFRDCSFYSISLLVLIYFFRDNRIFWWEALILFTIYIGYVAFMKWNVQVETCVKKMITKNKVTRV 500
            ||||.|||.:.|::||.||.||.|.|||:|:|.|.|..||.|||:|||||..||:||.:|||.:|
  Rat   239 LFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFAYVVFMKFNVQVERWVKQMINRNKVVKV 303

  Fly   501 RSTDQLMPAGNAANSSETSMATQPGGSVTSRAASETRSGPPGSSNAGATGNSSGGGGTSGSTQTG 565
            ..::....|..|.:..|.::..:|                           ....||:|.|.. .
  Rat   304 TVSEAQAKASTAGDKEEPTLPNKP---------------------------RLQRGGSSASLH-N 340

  Fly   566 AKFRHGLLQLMIHTIDPL-----------------HDGKVDEKATQLHAIASLKVLLDATKPQRG 613
            :..|:.:.||||||:|||                 .:|:..|||:.||.||..|..:|..:.|.|
  Rat   341 SLMRNSIFQLMIHTLDPLAEELGSYGKLKYYDTMTEEGRFREKASILHKIAKKKCQVDENERQNG 405

  Fly   614 GATTSAANHVKINLKETTLADRPNGNIDTTLDSPSLSGRRPSWIEQRVKIQTRKFSIKAPEI--- 675
                 |||||....::..|.:..:..::.|   ||.....|      |:......||:|.:.
  Rat   406 -----AANHVDYAAEKIELPNSTSTEVEMT---PSSEASEP------VQNGNLSHSIEAADAPQA 456

  Fly   676 -----EDEPEPLSMAWPDTARKRLTYVLVAPLLVPMWLTLPDTRTPRGKRFFPVTFIGSIVWIAA 735
                 ||:.:|||::||...||::|:::|.|::.|:|:||||.|.|..|:|||:||.|||.|||.
  Rat   457 TETAEEDDDQPLSLSWPSNTRKQITFLIVLPIVFPLWITLPDVRKPASKKFFPITFFGSITWIAV 521

  Fly   736 FSYLMVWWANVAGDTARIPPEVMGLTFLAAGTSIPDLITSVIVARKGFGDMAVSSSVGSNIFDVT 800
            |||||||||:..|:|..|..|:||||.||||||||||||||||||||.|||||||||||||||:|
  Rat   522 FSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDIT 586

  Fly   801 VGLPIPWLLYGIIYG-APVEVNSVGMVCSITILFMMLVFVVMSIACFRWRMNKGLGFTMFLLYFA 864
            ||||:|||||.||:. .||.|:|.|:.|:|.:||:||:||::|||..:|||||.|||.||.||||
  Rat   587 VGLPLPWLLYTIIHRFKPVTVSSNGLFCAIVLLFIMLIFVILSIALCKWRMNKILGFIMFGLYFA 651

  Fly   865 FVAVSLMFEYDVITCP 880
            |:.||::.|..|:.||
  Rat   652 FLVVSVLLEDKVLECP 667

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nckx30C	NP_652011.3	2A1904	<318..880	CDD:273344	308/587 (52%)
Slc24a2	NP_113931.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	67..86		5/32 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	91..122		10/48 (21%)
		2A1904	<99..670	CDD:273344	318/629 (51%)
		Alpha-1	175..215		33/39 (85%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	312..335		6/49 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	394..414		9/24 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	450..471		6/20 (30%)
		Alpha-2	550..581		29/30 (97%)