DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nckx30C and Slc24a2

DIOPT Version :9

Sequence 1:	NP_652011.3	Gene:	Nckx30C / 45248	FlyBaseID:	FBgn0028704	Length:	881	Species:	Drosophila melanogaster
Sequence 2:	NP_113931.1	Gene:	Slc24a2 / 84550	RGDID:	628650	Length:	670	Species:	Rattus norvegicus

Alignment Length:	731	Identity:	338/731 - (46%)
Similarity:	434/731 - (59%)	Gaps:	116/731 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 SRSRCR----SRRCLRLPIYSILLLCLTTQGLGLGDAAKPRPAKQHFGGSNSNSPNQNQNHNDVL 243
            |.|.||    :|:.|:|         :...||.:|..|...........:.:.|.|.....:||.
  Rat    20 SPSGCRRHYNTRKKLKL---------IRVIGLVMGLVAVSTVPFSISAFTETYSQNNRGEASDVT 75

  Fly   244 GGVGAPSQTSGEDEAEIMYPFQSGEQMFGLEE---DQEQDPELNSNAVPGSDEDNAGNQRGINDT 305
            |...||....              ..:..|.:   |....|       |.|.||.:.|  |.:..
  Rat    76 GPRAAPGHRQ--------------RTLLDLNDKIRDYTPQP-------PASQEDRSEN--GTDHA 117

  Fly   306 HNDNSTTTKTPLFPKDLFTKEQLENGAVILHIIGVIYMFVALAIVCDEFFVPSLDVIIEKLGITD 370
            ..|         :|||:|:.|:...||:|||:||:||||:||||||||||||||.||.|||||:|
  Rat   118 QGD---------YPKDVFSLEERRKGAIILHVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISD 173

  Fly   371 DVAGATFMAAGGSAPELFTSVIGVFVSFDDVGIGTIVGSAVFNILFVIGMCALFSKTVLSLTWWP 435
            ||||||||||||||||||||:||||::..:|||||||||||||||||||||||||:.:|:|||||
  Rat   174 DVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSREILNLTWWP 238

  Fly   436 LFRDCSFYSISLLVLIYFFRDNRIFWWEALILFTIYIGYVAFMKWNVQVETCVKKMITKNKVTRV 500
            ||||.|||.:.|::||.||.||.|.|||:|:|.|.|..||.|||:|||||..||:||.:|||.:|
  Rat   239 LFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFAYVVFMKFNVQVERWVKQMINRNKVVKV 303

  Fly   501 RSTDQLMPAGNAANSSETSMATQPGGSVTSRAASETRSGPPGSSNAGATGNSSGGGGTSGSTQTG 565
            ..::....|..|.:..|.::..:|                           ....||:|.|.. .
  Rat   304 TVSEAQAKASTAGDKEEPTLPNKP---------------------------RLQRGGSSASLH-N 340

  Fly   566 AKFRHGLLQLMIHTIDPL-----------------HDGKVDEKATQLHAIASLKVLLDATKPQRG 613
            :..|:.:.||||||:|||                 .:|:..|||:.||.||..|..:|..:.|.|
  Rat   341 SLMRNSIFQLMIHTLDPLAEELGSYGKLKYYDTMTEEGRFREKASILHKIAKKKCQVDENERQNG 405

  Fly   614 GATTSAANHVKINLKETTLADRPNGNIDTTLDSPSLSGRRPSWIEQRVKIQTRKFSIKAPEI--- 675
                 |||||....::..|.:..:..::.|   ||.....|      |:......||:|.:.
  Rat   406 -----AANHVDYAAEKIELPNSTSTEVEMT---PSSEASEP------VQNGNLSHSIEAADAPQA 456

  Fly   676 -----EDEPEPLSMAWPDTARKRLTYVLVAPLLVPMWLTLPDTRTPRGKRFFPVTFIGSIVWIAA 735
                 ||:.:|||::||...||::|:::|.|::.|:|:||||.|.|..|:|||:||.|||.|||.
  Rat   457 TETAEEDDDQPLSLSWPSNTRKQITFLIVLPIVFPLWITLPDVRKPASKKFFPITFFGSITWIAV 521

  Fly   736 FSYLMVWWANVAGDTARIPPEVMGLTFLAAGTSIPDLITSVIVARKGFGDMAVSSSVGSNIFDVT 800
            |||||||||:..|:|..|..|:||||.||||||||||||||||||||.|||||||||||||||:|
  Rat   522 FSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDIT 586

  Fly   801 VGLPIPWLLYGIIYG-APVEVNSVGMVCSITILFMMLVFVVMSIACFRWRMNKGLGFTMFLLYFA 864
            ||||:|||||.||:. .||.|:|.|:.|:|.:||:||:||::|||..:|||||.|||.||.||||
  Rat   587 VGLPLPWLLYTIIHRFKPVTVSSNGLFCAIVLLFIMLIFVILSIALCKWRMNKILGFIMFGLYFA 651

  Fly   865 FVAVSLMFEYDVITCP 880
            |:.||::.|..|:.||
  Rat   652 FLVVSVLLEDKVLECP 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nckx30C	NP_652011.3	Na_Ca_ex	336..480	CDD:279963	110/143 (77%)
Nckx30C	NP_652011.3	Na_Ca_ex	721..871	CDD:279963	108/150 (72%)
Slc24a2	NP_113931.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	67..86		5/32 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	91..122		10/48 (21%)
		TIGR00367	138..652	CDD:273039	294/555 (53%)
		Na_Ca_ex	139..281	CDD:279963	108/141 (77%)
		Alpha-1	175..215		33/39 (85%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	312..335		6/49 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	394..414		9/24 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	450..471		6/20 (30%)
		Na_Ca_ex	507..658	CDD:279963	108/150 (72%)
		Alpha-2	550..581		29/30 (97%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338080
Domainoid	1	1.000	231	1.000	Domainoid score	I2349
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H10669
Inparanoid	1	1.050	584	1.000	Inparanoid score	I970
OMA	1	1.010	-	-		QHG59101
OrthoDB	1	1.010	-	-		D1168500at2759
OrthoFinder	1	1.000	-	-		FOG0000196
OrthoInspector	1	1.000	-	-		oto95553
orthoMCL	1	0.900	-	-		OOG6_103716
Panther	1	1.100	-	-	LDO	PTHR10846
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1587
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.810