Protein Alignment Nckx30C and SLC8B1

DIOPT Version :10

• Sequence 1: NP_652011.3
• Gene: Nckx30C / 45248
• FlyBaseID: FBgn0028704
• Length: 881
• Species: Drosophila melanogaster
• Sequence 2: NP_079235.2
• Gene: SLC8B1 / 80024
• HGNCID: 26175
• Length: 584
• Species: Homo sapiens
• Alignment Length: 615
• Identity: 134/615 - (21%)
• Similarity: 228/615 - (37%)
• Gaps: 181/615 - (29%)

  Fly   318 FPKDLFTKEQLENGAVILHIIGVIYMFVALAIVCDEFFVPSLDVIIEKLGITDDVAGATFMAAGG 382
            ||..|...      ||.|::..::|:|:.|.:...:||.|:|..|...|.::.:|||.||:|.|.
Human    91 FPPSLLPL------AVTLYVSWLLYLFLILGVTAAKFFCPNLSAISTTLKLSHNVAGVTFLAFGN 149

  Fly   383 SAPELFTSVIGVFVSFDD-----VGIGTIVGSAVFNILFVIGMCALFSKTVLSLTWWPLFRDCSF 442
            .||::|:::    |:|.|     :.:|.:.|:.|.....|.|...:....:.:..  |.|||..|
Human   150 GAPDIFSAL----VAFSDPHTAGLALGALFGAGVLVTTVVAGGITILHPFMAASR--PFFRDIVF 208

  Fly   443 YSISL-LVLIYFFRDNRIFWWEA--LILFTIYIGYVAFMKWNVQVETCVKKMITKNKVTRVRSTD 504
            |.::: |..:..||......|..  |.|:..|:..|....|..|               |.|...
Human   209 YMVAVFLTFLMLFRGRVTLAWALGYLGLYVFYVVTVILCTWIYQ---------------RQRRGS 258

  Fly   505 QLMPAGNAANSSETSMATQP---GGSVTSRAASETRSGPPGSSNAGATGNSSGGGGTSGSTQTGA 566
            ...|           |...|   ..|...|.:|.|                       .|...|.
Human   259 LFCP-----------MPVTPEILSDSEEDRVSSNT-----------------------NSYDYGD 289

  Fly   567 KFR------HGLLQLMIHTIDPLHDGKVDEKATQLHAIASLKVLLDATKPQRGGATTSAANHVKI 625
            ::|      ....|:::..::|                      ||..|.:|..|...|....|:
Human   290 EYRPLFFYQETTAQILVRALNP----------------------LDYMKWRRKSAYWKALKVFKL 332

  Fly   626 NLKETTLADRPNGNIDTTLDSPSLSGRRPSWIEQRVKIQTRKFSIKAPEIEDE--PEPLSMAWPD 688
            .::...|...|                                 :..|:.:|:  ..||:
Human   333 PVEFLLLLTVP---------------------------------VVDPDKDDQNWKRPLN----- 359

  Fly   689 TARKRLTYVLVAPL------------------LVPMWLTL---------------PDTRTPRGKR 720
                 ..:::::||                  |||:|:.:               .|::.||...
Human   360 -----CLHLVISPLVVVLTLQSGTYGVYEIGGLVPVWVVVVIAGTALASVTFFATSDSQPPRLHW 419

  Fly   721 FFP-VTFIGSIVWIAAFSYLMVWWANVAGDTARIPPEVMGLTFLAAGTSIPDLITSVIVARKGFG 784
            .|. :.|:.|.:||.|.:..:|......|...|:...|:|||.||.|.||.|..:...:||:|:.
Human   420 LFAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLARQGYP 484

  Fly   785 DMAVSSSVGSNIFDVTVGLPIPWLLYGIIYGAPVEVNSVGMVCSIT--ILFMMLVFVVMSIACFR 847
            .||.|:..|..||::.||:.:..||........|::...|::..:.  .|.:.|||.::|:....
Human   485 RMAFSACFGGIIFNILVGVGLGCLLQISRSHTEVKLEPDGLLVWVLAGALGLSLVFSLVSVPLQC 549

  Fly   848 WRMNKGLGFTMFLLYFAFVAVSLMFEYDVI 877
            :::::..||.:.|.|..|:.|:|:.|:.||
Human   550 FQLSRVYGFCLLLFYLNFLVVALLTEFGVI 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nckx30C	NP_652011.3	2A1904	<318..880	CDD:273344	134/615 (22%)
SLC8B1	NP_079235.2	PLN03151	63..584	CDD:215604	134/615 (22%)