DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nckx30C and slc24a1

DIOPT Version :9

Sequence 1:	NP_652011.3	Gene:	Nckx30C / 45248	FlyBaseID:	FBgn0028704	Length:	881	Species:	Drosophila melanogaster
Sequence 2:	XP_009291877.2	Gene:	slc24a1 / 558299	ZFINID:	ZDB-GENE-060503-191	Length:	741	Species:	Danio rerio

Alignment Length:	717	Identity:	308/717 - (42%)
Similarity:	406/717 - (56%)	Gaps:	119/717 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   263 PFQSGEQMFG----LEEDQEQDPELNSNAV---PGSDEDNAGNQRGINDTHNDNSTTTKTPL--- 317
            |.::|:...|    ||....:.||:.:|:.   |.:.::...::...|......||||:.|.
Zfish    42 PQRAGDPEDGSGLALEGGLSEMPEVMTNSTTVHPKNSDEVRSSETVTNAPVLTTSTTTEAPSTTT 106

  Fly   318 ------------------------------------------------FPKDLFTKEQLENGAVI 334
                                                            :|:|:|:.|....|.|.
Zfish   107 NRTIVHCIYVDPDLPKPTPVPTPATETTTLVPNTTAPQPGDAPHMKGEYPEDIFSIEDRRKGWVS 171

  Fly   335 LHIIGVIYMFVALAIVCDEFFVPSLDVIIEKLGITDDVAGATFMAAGGSAPELFTSVIGVFVSFD 399
            |||.|::||||:|||||||||||:|.||.:||.|:|||||||||||||||||||||:||||:|..
Zfish   172 LHIFGMVYMFVSLAIVCDEFFVPTLGVITDKLAISDDVAGATFMAAGGSAPELFTSLIGVFISHS 236

  Fly   400 DVGIGTIVGSAVFNILFVIGMCALFSKTVLSLTWWPLFRDCSFYSISLLVLIYFFRDNRIFWWEA 464
            :|||||||||||||||||||||||||:.:|.|||||||||.|||.:.|::||.||.||.|.|||:
Zfish   237 NVGIGTIVGSAVFNILFVIGMCALFSREMLHLTWWPLFRDVSFYILDLIMLIIFFLDNTIMWWES 301

  Fly   465 LILFTIYIGYVAFMKWNVQVETCVKKMITKNK-VTRVRSTDQLMPAGNAANSSETSMATQPGGSV 528
            ::|...|..||.|||:|||:|...|..::|:| :.:|.:.::  |..:...|.|
Zfish   302 MMLVGGYALYVTFMKFNVQLERAFKSQLSKHKSIVKVIAVEE--PEKDNGTSGE----------- 353

  Fly   529 TSRAASETRSGPPGSSNAGATGNSSGGGGTSGSTQTGAKFRHGLLQLMIHTIDPLHDG------- 586
                  |.|...|...|......:...||:|.|.. .:..|:.:.||||||:|||.:.
Zfish   354 ------ENRPPEPEDKNRLKLKPTLQRGGSSASLH-NSTMRNTIFQLMIHTLDPLGEESVFNGDA 411

  Fly   587 ----------KVDEKATQLHAIASLKV-------------LLDATKPQRG---GATTSAANHVKI 625
                      |..:||..|:.:|..||             ..:.||..:.   ||.....|....
Zfish   412 KARSSLECKVKFKDKAQILNDMARGKVENKKKEKSGEGDDQSEQTKDSKDAPPGAKDEDTNQKSE 476

  Fly   626 NLKETTLA-----DRPNGNIDTTLDSPSLSGRRPSWIEQRVKIQTRKFSIKAPEI-EDEPEPLSM 684
            ..|:..:|     :.|.|:.::..|....|.......:...............|. ||..||||:
Zfish   477 AQKDGDIAAGGGSENPGGSDNSGDDDEDDSDEESDDDDDDDDDDDDDDDENEDEAGEDGDEPLSL 541

  Fly   685 AWPDTARKRLTYVLVAPLLVPMWLTLPDTRTPRGKRFFPVTFIGSIVWIAAFSYLMVWWANVAGD 749
            .||||.||:.||:.:.|::.|:|||:||.|.|..|:||.:||:|||||||.|||||||||:..|:
Zfish   542 EWPDTRRKQATYLFLLPIVFPLWLTVPDVRNPASKKFFVITFLGSIVWIAIFSYLMVWWAHQVGE 606

  Fly   750 TARIPPEVMGLTFLAAGTSIPDLITSVIVARKGFGDMAVSSSVGSNIFDVTVGLPIPWLLYGIIY 814
            |..|..|:||||.||||||||||||||||||||.|||||||||||||||:|:|||:|||::...:
Zfish   607 TIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITMGLPVPWLMFSFFH 671

  Fly   815 G-APVEVNSVGMVCSITILFMMLVFVVMSIACFRWRMNKGLGFTMFLLYFAFVAVSLMFEYDVIT 878
            . |||.|:|.|:.|:|.:||:||:||::|||..:|||||.||||||:|||.|:.:|:|.|..:|.
Zfish   672 SFAPVPVSSNGLFCAIVLLFLMLLFVIISIAACKWRMNKVLGFTMFILYFVFLVLSVMLEDRIIV 736

  Fly   879 CP 880
            ||
Zfish   737 CP 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nckx30C	NP_652011.3	Na_Ca_ex	336..480	CDD:279963	105/143 (73%)
Nckx30C	NP_652011.3	Na_Ca_ex	721..871	CDD:279963	103/150 (69%)
slc24a1	XP_009291877.2	Na_Ca_ex	<112..741	CDD:332332	293/647 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577444
Domainoid	1	1.000	217	1.000	Domainoid score	I2612
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	540	1.000	Inparanoid score	I1146
OMA	1	1.010	-	-		QHG59101
OrthoDB	1	1.010	-	-		D1168500at2759
OrthoFinder	1	1.000	-	-		FOG0000196
OrthoInspector	1	1.000	-	-		otm25833
orthoMCL	1	0.900	-	-		OOG6_103716
Panther	1	1.100	-	-	O	PTHR10846
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3797
SonicParanoid	1	1.000	-	-		X1587
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.900